Botulin A use while Breastfeeding

Botulin A Levels and Effects while Breastfeeding

Summary of Use during Lactation

No data exist on the medical use of botulin A (botulinum toxin) during breastfeeding. However, one infant was safely breastfed during maternal botulism and no botulinum toxin was detectable in the mother's milk or infant. Since the doses used medically are far lower than those that cause botulism, amounts ingested by the infant, if any, are expected to be insignificant and not cause any adverse effects in breastfed infants. No special precautions are required.

Drug Levels

Maternal Levels. Published information on the medical use of botulin A during breastfeeding was not found as of the revision date.

A woman with documented botulism was given 2 vials of trivalent botulism antitoxin, 1 intravenously and 1 intramuscularly. A milk sample obtained 4 hours after administration of the antitoxin had no detectable botulinum toxin nor botulism organisms.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Published information on the medical use of botulin A during breastfeeding was not found as of the revision date.

A woman developed botulism after ingesting fermented salmon eggs while breastfeeding her 8-month-old infant (extent not stated). Type A botulinum toxin was detected in the woman's blood and stools. No botulinum toxin was detected in the infant's blood or stool on the day the mother was admitted to the hospital and no botulism organisms were detected in the infant's stools. The infant developed no signs or symptoms of botulism even though she continued to nurse throughout the mother's hospitalization.[1]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. Middaugh J. Botulism and breast milk. N Engl J Med. 1978;298:343. PMID: 622098

Botulin A Identification

Substance Name

Botulin A

CAS Registry Number

93384-43-1

Drug Class

Bacterial Toxins

Neuromuscular Agents

Neurotoxins

Administrative Information

LactMed Record Number

521

Last Revision Date

20130907

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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