Benazepril use while Breastfeeding
Drugs containing Benazepril: Lotrel, Lotensin, Lotensin HCT, Amlobenz
Benazepril Levels and Effects while Breastfeeding
Summary of Use during Lactation
Because of the low levels of benazepril in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.
Drug Levels
Benazapril is an inactive drug that is metabolized to the active metabolite benazaprilat. Benazaprilat is poorly absorbed orally.
Maternal Levels. In 9 women (time postpartum not stated) given an oral dose of 20 mg of benazepril daily for 3 days, peak milk levels of 0.9 mcg/L of benazepril at 1 hour after the dose and 2 mcg/L of its active metabolite benazeprilat at 1.5 hours after the dose were detected. The authors estimated that the infant would receive a dose less than 0.14% of the mother's weight-adjusted dose of benazepril, mostly as benazeprilat.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Captopril, Enalapril, Quinapril
References
1. Kaiser G, Ackerman R, Dieterle W et al. Benazepril and benazeprilat in human plasma and breast milk. Eur J Clin Pharmacol. 1989;36(suppl):A303. Abstract.
Benazepril Identification
Substance Name
CAS Registry Number
86541-75-5
Drug Class
- Antihypertensive Agents
- Angiotensin-Converting Enzyme Inhibitors
Administrative Information
LactMed Record Number
26
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2011-07-05
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Benazepril use during Pregnancy
- Benazepril Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.
