Benazepril use while Breastfeeding

Drugs containing Benazepril: Lotrel, Lotensin, Lotensin HCT, Amlobenz

Benazepril Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because of the low levels of benazepril in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.

Drug Levels

Benazapril is an inactive drug that is metabolized to the active metabolite benazaprilat. Benazaprilat is poorly absorbed orally.

Maternal Levels. In 9 women (time postpartum not stated) given an oral dose of 20 mg of benazepril daily for 3 days, peak milk levels of 0.9 mcg/L of benazepril at 1 hour after the dose and 2 mcg/L of its active metabolite benazeprilat at 1.5 hours after the dose were detected. The authors estimated that the infant would receive a dose less than 0.14% of the mother's weight-adjusted dose of benazepril, mostly as benazeprilat.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Captopril, Enalapril, Quinapril

References

1. Kaiser G, Ackerman R, Dieterle W et al. Benazepril and benazeprilat in human plasma and breast milk. Eur J Clin Pharmacol. 1989;36(suppl):A303. Abstract.

Benazepril Identification

Substance Name

Benazepril

CAS Registry Number

86541-75-5

Drug Class

  • Antihypertensive Agents
  • Angiotensin-Converting Enzyme Inhibitors

Administrative Information

LactMed Record Number

26

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

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