Aminosalicylic Acid use while Breastfeeding

Drugs containing Aminosalicylic Acid: Paser

Aminosalicylic Acid Levels and Effects while Breastfeeding

Summary of Use during Lactation

Limited information indicates that maternal aminosalicylic acid therapy produces low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Exclusively breastfed infants should be monitored for rare instances of jaundice, gastrointestinal disturbances, hypokalemia, thrombocytopenia, hemolysis and hypokalemia if this drug is used during lactation.[1]

Drug Levels

Maternal Levels. One woman who was lactating, but not breastfeeding (time postpartum not stated) took a single 4 gram oral dose of aminosalicylic acid. A peak milk level of 1.1 mg/L occurred at 3 hours after the dose. The drug's half-life in milk was estimated to be 2.5 hours.[1] Using these data, a fully breastfed infant would receive a maximum of about 0.25% of the maternal weight-adjusted dosage.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Aminosalicylic acid was used as part of multi-drug regimens to treat 2 pregnant women with multidrug-resistant tuberculosis throughout pregnancy and postpartum. Their two infants were breastfed (extent and duration not stated). At age 1.8 and 4.6 years, the children were developing normally, except for except for a mild speech delay in one at age 1.8 years, and failure to thrive in the other, possibly due to tuberculosis contracted after birth.[2]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

References

1. Holdiness MR. Antituberculosis drugs and breast-feeding. Arch Intern Med. 1984;144:1888. Letter. PMID: 15889370

2. Drobac PC, del Castillo H, Sweetland A et al. Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents. Clin Infect Dis. 2005;40:1689-92. PMID: 15889370

Aminosalicylic Acid Identification

Substance Name

Aminosalicylic Acid

CAS Registry Number

65-49-6

Drug Class

Antitubercular Agents

Administrative Information

LactMed Record Number

445

Last Revision Date

20140116

Disclaimer

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