5 Mar 2010
Male and Female Sexual Dysfunction with SSRIs
Although changes in sexual desire, sexual performance and sexual satisfaction often occur as manifestations of a psychiatric disorder, they may also be a consequence of pharmacologic treatment. In particular, some evidence suggests that selective serotonin reuptake inhibitors (SSRIs) can cause such untoward sexual experiences. Reliable estimates of the incidence and severity of untoward experiences involving sexual desire, performance and satisfaction are difficult to obtain, however, in part because patients and physicians may be reluctant to discuss them. Accordingly, estimates of the incidence of untoward sexual experience and performance cited in product labeling are likely to underestimate their actual incidence.
Table 5 below displays the incidence of sexual side effects reported by at least 2% of patients taking Zoloft in placebo-controlled trials.
TABLE 5 Adverse Event Zoloft Placebo
Denominator used was for male patients only (N=1118 Zoloft; N=926 placebo)
Denominator used was for male and female patients (N=2799 Zoloft; N=2394 placebo)
(primarily delayed ejaculation) 14% 1%
Decreased libido† 6% 1%
There are no adequate and well-controlled studies examining sexual dysfunction with sertraline treatment.
Priapism has been reported with all SSRIs.
While it is difficult to know the precise risk of sexual dysfunction associated with the use of SSRIs, physicians should routinely inquire about such possible side effects.
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
If there are sexual side effects with Mirtazapine, what are they? I seem to have lost about 50% of my sexual desire after I started taking ...
1 answer • 30 Jul 2010
Hi there, I'm 35 and this is my first experience with antidepressants. I took zoloft 50mg for 3 weeks against depression. Because of the sexual ...
2 answers • 26 Oct 2012
I was wondering if Zoloft caused bad sexual side effects or weight gain?
4 answers • 4 Feb 2014
I just recently started taking Zoloft, and im finding that im unable to finish ( if you know what I mean). Im a 24 year old male, so its a little ...
2 answers • 23 Feb 2014
I'm currently on Lexapro for chronic anxiety and depression, and the sexual side effects are horrible! I am prescribed buspar to offset some of ...
4 answers • 8 days ago