I have been on zoloft, prozac,effexor & paxil since1981 with horrific weight gain? Can any of these drugs cause this? I also have severe neuropathy, depression,sex drive is down tremendouly, swelling in lower extremities, some loss of memory, etc. Tell me what can cause these symptoms? also had 65lb growth which shut down kidneys, my hands stopped working, and am now in wheelchair because i also lost ability to stand and walk. i also have tremors sometime. Please send me any information you have on these drugs. shegod3
Can any of these drugs cause weight gain - zoloft, prozac,effexor & paxil?
- Posted:
- 20 Aug 2012 by shegod3
- Topics:
- effexor, paxil, prozac, zoloft, depression, peripheral neuropathy, obesity, amyotrophic lateral sclerosis, weight, swelling, sex, sex drive
Answers (6)
20 Aug 2012
At the top of the page is a search window in which you can type each of these medications and read about them. Weight gain is a possibility on any of these medications. As to whether the weight gain is actually caused by the medication is contreversial. Since you are wheelchair bound and unable to get much exercise, reducing your calorie intake is critical. To prevent weight gain you must burn more calories than you are consuming. Sounds, based on what you have shared, that you have several conditions affecting your health of which depression is just one. As to which of these conditions might be caused from the antidepressants is difficult to tell. Antidepressants can decrease sex drive. Some antidepressants are known to help neuropathy. Swelling in lower extremeties could be a result of decreased kidney function. As to the inability to stand, walk, and hand tremors sounds like a neurologic problem. Just my opinions, as I am not a doctor.
21 Aug 2012
I finally gave up all antidepressants, with a doctor's help, and I have lost over 50 pounds without trying. I also gained the weight without trying and was accused of eating too much,not exercising enough etc. I was VERY frustrated!! I also have problems with water weight. I do know that it is the gabapentin that I take for pain, though. I used to take 1200mg/3X/day, and now I only take 300mg once a night. That helps me get up in the AM. It is a great medication for me, but not the water weight. Unfortunately, I've been told by my doctor that the swelling will never go away, because the lymph system is the size of a hair follicle, and with that much fluid in me it's simply not going away. I guess that I have to live with "Cankles" the rest of my life. Not happy about that, but he was right, the fluid collection is just not going down regardless of how much weight I drop.
Best of luck to you!!
21 Aug 2012
Hi shegod3, I have been on several anti-depressants in my lifetime, and the only one that didn't cause weight gain, or lack of sexual desire, is Wellbutrin.
I know from personal experience that Effexor causes weight gain. I have never had this on any other anti-depressant.
Very good. Glad to hear it. (if you needed to gain weight) The numbere vary. Majority of people say on Zoloft gain no weight. There are people that yes, put on weight but its not known as a weight gaining drug. I was on Effexor, years ago, actually lost weight.
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Similar questions
Been taking Effexor XR for several years - should my doctor order lab studies?
Since I have been taking it I have gain 60 pounds I did only weigh 110 pounds now I weigh 165 pounds. Also I have strange dreams every night and I ...
Has anyone had problems with weight gain while being on Cymbalta?
I have been on Cymbalta for several years after being diagnosed with Rheumatoid Arthritis and Fybromyalga after my second child. I have gained so ...
Anyone taking Zoloft with Effexor?
I have been taking Zoloft for years and swear by it—at least for depression and self-esteem enhancer. Unfortunately when I increase the dosage ...
Swich prozac to zoloft?
I was on prozac 40mg and I recently switch it to zoloft, the first 2 day 25mg and today is 3d I took 50mg, I have to visit my dr in 2 weeks, I have ...
What do I do next if, after several years, Wellbutrin 450 mg. a day has stopped working?
I have suffered from low-grade depression symptoms for the last 20 years. I began with Prozac, a miracle but it made me gain weight. Next was ...

Moreover, if you're a smoker, it helps tremendously for smoking cessation! Good luck!!