I started experiencing depression, nervousness, and anxiety/panic about 6 weeks ago. Also, symptoms of OCD (intrusive/unwanted thoughts which lead to fear and fear of the thoughts). I was put on 50mg of zoloft a day and didn't start to really feel better until about 3 1/2 or 4 weeks. Then, at about 5 1/2 weeks I took another turn and started having the bad feelings and unwanted thoughts and fears again. It's hard not to fear that I am going crazy or something and that there is no help for me and that this medicine is not going to relieve my problems. I am however, hoping that because I have only been on 100mg for 1 week, that perhaps it will just take another 2-3 weeks to feel the full affect of this new dose. Do you think that is a legitimate rational? Thank you for your feedback.