Why is Sansert no longer available in the US?

5 Sep 2011

Methysergide, also known as Sansert, was widely used for migraine prevention for more than 50 years. While this drug is still available in Canada, it was removed from the U.S. market in 2003 because of complications related to extended use. Patients were at a high risk of developing retroperitoneal fibrosis, a disease that attacks the fibrous tissue in the retroperitoneum, the portion of the body containing the kidneys and renal tract. This is a slowly progressive disease and is also called chronic periaortitis when associated with an abdominal aortic aneurysm.