Why is etanercept (enbrel) administered differently from aspirin?

2 Nov 2009

This is only a guess... Asprin need stomache juices to prevent bleeding out. Now Embrel if given orally you would probably bleed out all the way through the esophagus into the stomache. This is caused by the the break down of the cellular make up. If injected it prevents this rapid break down. It goes directly into the blood stream. Just think if you injected asprin directlly into the body, the chances of a complete bleed out throughout the system is quite high.

This is only a guess, hope it helps

31 Jan 2011

Enbrel is a anti-TNF produced using Chinese Hamster Ovary by rDNA technology. It is a fusion protein and is indicated for use in moderate to severe Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis and plague Psoriasis.
It needs to be injected and cannot be taken orally (like aspirin). Since it is a fusion protein (biologic drug) it is broken down by the enzymes, acids etc in the esophagus and stomach.
This causes reduced action and denaturation of these biologically active substances. Hence they are administered through infusion or injection for best outcomes.
Hope this helps!