Why caffeine increase the absorption of ergotamine?
- Posted:
- 23 May 2010 by Abo El Fadl
- Topics:
- migraine, caffeine, ergotamine
Answers (1)
suzanne6626 May 2010
Caffeine increases both the rate and extent of absorption of ergotamine when given together.
Caffeine is thought to exert its rate-accelerating effect by increasing the water solubility of ergotamine - thereby assisting ergotamine absorption from a lipid phase (GI membrane) into an aqueous phase (blood).
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