I am actually asking for my husband who has nerve damage in his back and has been prescribed both for the pain and we are just curious because he takes one of them every 4 hours and then 4 hours later takes the other. He alternates between the 2 if the pain is severe enough. Sometimes neither one is enough to get rid of the pain which runs down into his left heel... we welcome any suggestions or comments. Thanks
9 May 2010
I would have to say the oxy cause my husband took it and I can't say it exactly helped him to much but it did have the round the clock pain relief he was looking for. I must also mention that and I know it says stricktly not to do this but I have dabbled in it from time to time to try crushing or breaking it in half then swallow it broken up it releases the medicine a little quicker but be careful with this some people are not good with quick release drugs and this would send an instant pain relief instead of waiting for the time release. You didn't hear this from me but my husband's nurse had told him it was okay to do so I don't really see the harm in seeing how it might be able to help your husband. Hope this helped you.
26 Nov 2011
It really depends in the patient. Oxymorphone can be extended release or instant release. I'm guessing if you have both, that the oxymorphone is probably extended release. Typically if someone is suffering from chronic pain, they will be prescribed a controlled release analgesic along with an immediate release for breakthrough pain. I think maybe you might want to clarify the dosing schedule with the Dr who prescribed them. Don't break them down, that's considered drug abuse in a technically sense. If your doctor finds out he will most likely drop the patient. It is also illegal. That being said, as to which is stronger is highly dependant on the individual. Hydromorphone is in no way more potent, unless you mean mg for mg. Mg for mg hydromorphone is slightly more potent (orally). As far as which is more potent as far analgesia, it really depends.
At equivalent analgesic doses, oxymorphone is more powerful ( in intensity, not potency), at least in my experience. However, hydromorphone has provided me an equal amount of pain relief with less side effects.
29 Jan 2015
Assuming you DO mean oxymorphone (and not oxycodone - a mistake people often make), here is what you need to know:
Mg for mg, hydromorphone is approximately 33% "stronger". That is to say, 1mg of hydromorphone is equivalent to 1.33 mg of oxymorphone.
However, assuming your husband is taking both orally, you also have to consider the bioavailability (BA) of both substances:
Neither are particularly effective in terms of oral BA, but hydromorphone generally accepted to be approx 30% bioavailable when taken orally. Oxymorphone is accepted to be approx 10% bioavailable when taken orally (both figures are for someone with normal liver and kidney function).
Whether extended release or immediate release helps your husband is entirely dependant on his pain profile, not on the "strength" of one versus the other. The only difference btwn XR and IR hydromorphone is the time over which the medication is delivered - the medication itself is the same.
So... To answer the strength question: Overall, hydromorphone is stronger AND about 3x more bioavailable when taken orally.
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