In the process of switching from Cymbalta to Pristiq so have to wean off of the Cymbalta which I presently take at night. After reading some of the reviews it looks as though everyone has some insomnia on Pristiq. I have Rheumatoid Arthritis, Fybro, extreme fatigue and have gained lots of weight from the Cymbalta. So I need to get my energy back, take away my pain and hopefully lose some weight in the meantime just wanted some feedback to what everyone thinks about a good time to take the medication.