5 Jun 2011
Not a good combination. The methodrexate is already causing your liver to work hard and the alcohol just makes it worse. The interaction between these two substances is as follows:
methotrexate ↔ ethanol
Applies to: methotrexate, Alcohol (contained in alcoholic beverages) (ethanol)
GENERALLY AVOID: Coadministration of methotrexate with other agents known to induce hepatotoxicity may potentiate the risk of liver injury. Methotrexate, especially at higher doses or with prolonged treatment, has been associated with hepatotoxicity including acute hepatitis, chronic fibrosis, necrosis, cirrhosis, and liver enzyme elevations.
MANAGEMENT: The use of methotrexate in combination with other potentially hepatotoxic agents (e.g., acetaminophen; alcohol; androgens and anabolic steroids; antituberculous agents; azole antifungal agents; ACE inhibitors; endothelin receptor antagonists; interferons; nucleoside reverse transcriptase inhibitors; retinoids; thiazolidinediones; anticonvulsants such as carbamazepine, hydantoins, felbamate, and valproic acid; lipid-lowering medications such as fenofibrate, HMG-CoA reductase inhibitors, and niacin; herbals and nutritional supplements such as black cohosh, chaparral, comfrey, DHEA, kava, pennyroyal oil, and red yeast rice) is generally not recommended unless the potential benefit outweighs the risk. Patients treated with methotrexate should be advised to seek medical attention if they experience potential signs and symptoms of hepatotoxicity such as fever, rash, itching, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, light-colored stools, and jaundice. Baseline and regular monitoring of hepatic function is recommended.
So I don't recommend excessive drinking while taking methotrexate as it may permanently damage your liver.
- Methotrexate Information for Consumers
- Methotrexate Information for Healthcare Professionals (includes dosage details)
- Side Effects of Methotrexate (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Throwing up every single time I drink alcohol, even if it's just 3 beers or a whole bottle of liquor. This never used to happen to me, I was ...
4 answers • 23 Jan 2011
I have just started taking vyvanse two weeks ago and I'm wondering how safe it is to drink alcohol.?
... I'm 19 and I do like to sometimes go out on weekends with friends or have some drinks. But on weekdays I never have any alcohol. But ...
1 answer • 15 Apr 2011
I understand how dangerous it is to mix Xanax and alcohol, so of course I would never even attempt it. I have been on 1 mg. Xanax for 2 years now to ...
3 answers • 23 May 2013
trying to explain to someone with type 2 diabetes why they shouldn't drink alcohol in excess. They keep arguing that phenol is same thing as ...
1 answer • 25 Jun 2014
My coworker forgot that I started methotrexate last night and put baileys in my coffee. I feel bad dumping it out so I just want to know if the odd ...
2 answers • 11 Dec 2014