Skip to Content

What will happen if I drink an excess of alcohol while I take Methotrexate?

Question is Closed
Report Favorite

Answers (1)

5 Jun 2011

Hey cindylou,

Not a good combination. The methodrexate is already causing your liver to work hard and the alcohol just makes it worse. The interaction between these two substances is as follows:

methotrexate ↔ ethanol

Applies to: methotrexate, Alcohol (contained in alcoholic beverages) (ethanol)

GENERALLY AVOID: Coadministration of methotrexate with other agents known to induce hepatotoxicity may potentiate the risk of liver injury. Methotrexate, especially at higher doses or with prolonged treatment, has been associated with hepatotoxicity including acute hepatitis, chronic fibrosis, necrosis, cirrhosis, and liver enzyme elevations.


Votes: +1
Anonymous 5 Jun 2011

Amen Laurie, my husband is on methatrexate for RA and he has to have his liver ckecked very often, they have him on folic acid too. It is very important you do not drink.

Further Information

Search for questions

Still looking for answers? Try searching for what you seek or ask your own question.

Similar questions

i am about to start injecting methotrexate and would like to know how much alcohol is safe to consu?

i was taking the tablet form of methotrexate but was quite sick after having only 2 pints but i understand i may not react in the same way when i ...

1 answer 12 Aug 2009

I have just started taking vyvanse two weeks ago and I'm wondering how safe it is to drink alcohol.?

... I'm 19 and I do like to sometimes go out on weekends with friends or have some drinks. But on weekdays I never have any alcohol. But ...

1 answer 15 Apr 2011

Xanax: Is it possible to skip my nightly dose of Xanax (1 mg.) to go to a party and drink alcohol?

I understand how dangerous it is to mix Xanax and alcohol, so of course I would never even attempt it. I have been on 1 mg. Xanax for 2 years now to ...

3 answers 23 May 2013

Please explain why glycerol and phenol are not the same thing as drinking alcohol?

trying to explain to someone with type 2 diabetes why they shouldn't drink alcohol in excess. They keep arguing that phenol is same thing as ...

1 answer 25 Jun 2014

Is it okay to have a casual drink every so often while on methotrexate?

My coworker forgot that I started methotrexate last night and put baileys in my coffee. I feel bad dumping it out so I just want to know if the odd ...

2 answers 11 Dec 2014