I was recently changed from my antidepressant Celexa to Cymbalta 60mg to treat both depression and fibromalygia, as this drug is approved to treat both conditions. I first started it about 5 weeks ago at full dose, so I have given it plenty of time. However, I'm not happy with it for depression, and am curious to see what others' experiences are. I was previously on Celexa, and though it wasn't working like it used to, I feel it worked better than Cymbalta.
I'm not "depressed" in the sense that I'm sad, crying, or technically unhappy. My problem since getting on Cymbalta is a major feeling of apathy, lack of internal drive, lack of interest in social life, no enjoyment in activities that I previous liked, etc. I'm on work leave because of seizure management and a shoulder injury, but I am able to focus on small tasks, and do the house work and clean/organize our home -- though these small things take me an entire day, as I lose focus and don't do it all at once.
Side effects: the medication also makes me absolutely exhausted -- I've tried taking it in the morning, at night, etc. I get different side effects at different times of the day -- taking it at anytime except bedtime causes severe nausea and headaches; therefore bedtime it is, so I battle insomnia (not too bad anymore). No matter what, even on 12 hours of sleep, I'm always exhausted and completely apathetic. I feel like I don't enjoy much of anything, I've lost interest in fun, in life. This is obviously a symptom of depression -- not sure if I should give this more time, as antidepressants can take up to 4-8 weeks for complete effectiveness, but I'd prefer not to waste any more time on a drug that doesn't work for me.
What has anyone else experienced in terms of effectiveness of Cymbalta for depression, and side effects? Length of time (for efficacy & for side efffects to subside, if relevant)?

Thanks so much for your comments. I agree that it is amazing for pain, it has helped my fibromyalgia so much. As I am approaching the 6-week mark since starting the Cymbalta, it seems the side effects are subsiding, and I am starting to feel more of the anti-depressant effect. The only side effect I really have now is fatigue, however, it is to be expected, combined with the other medications for seizures that I take. As an RN, I know anti-depressants can take up to 6 weeks to work, however, usually effects are seen at least by 4 weeks, so I am surprised, but hopeful that this may end up working.
Thanks for your support and insight.
LO
Hi,
I too, tried Cymbalta for the same reason a year or so ago. I really could tell that it was helping with the chronic pain factor. For me personally however, the weight gain it caused made it not worth it- (depressing, yeah!)
It sounds like you've really already made up your mind on it- and to tell the truth that's the one and only thing I believe in going by in the end because everyone responds so differently. And no one else lives in your body!
You might however, check with your doctor (or your charts) to see if 60mg is the max dosage or even the equivilant of what you took on the other antidepressant. I'm not sure that 5 weeks is exactly long enough to have true "theraputic" effect. You might want to give it just one or two more weeks, cause again- nothing about the meds or the interactions between the different ones you may be on are written in stone.
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(Interesting to me that you suffer from seizures- I just got over that! HALLELUJAH! I found that having a seizure disorder was terribly isolating (understatement of the year for me) and made my Depression with a capial D even harder to deal with. I am really working hard at rebuilding my life now and social interaction is a biggie after being virtually housebound... )
I wish you good luck in all~
Courage for your battles
Inspiration for your dreams...
Hold your head high* my friend
and smile~
prism
I too have been taking Cymbalta for a couple of yrs. now and with a combination of Wellbutrin and Adderall it has saved my life! It was prescribed for Fybromyalgia with Severe Depression and Chronic Fatigue.
After numerous other drugs we finally got the combination right and OMG I had my life back! I went from being so hateful I couldn't stand myself and sleeping 20 (yes 20!) hours a day, to being my normal, up beat self. This didn't just happen overnight. It took awhile to get the doseages for each med just right. I was taking 60mg Cymbalta, 450mg Wellbutrin XL, and 10mg Adderall XR daily. I had no idea how well this controlled the Fybro pain and depression and the Adderall kept me from sleeping all the time. I can't even think of any side effects I suffered. This has truely been a miracle for me. (now I need another miracle).
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I was put on permanent disability (social security) due to the illnesses about a year ago and recently went through a divorce and with that went my health insurance. I now find myself unable to pay for my meds due to the high cost ($1,100 a month for 3 meds!) and am going off all three cold turkey (Does any one have a gun!!! lol). Thats how I came across this website trying to find out about withdrawl (maybe the site is the mircle? God works in mysterious ways!). I'm not having the ZAPs everyone is talking about. I have never experienced them. Its the nausea, headaches from hell, and sleeping all the time (again). And did I mention I am eating anything that isn't nailed down? I've gained 12 lbs in two months and never gained while I was on the meds. After reading about others and their withdrawl problems I feel lucky compared to most but this is AWFUL! I WANT MY DRUGS !!! I would never stop taking them if I didn't have to.
Just thought I would share - I know everything works differently on everyone but I just thought I would let you know I found light at the end of the tunnel and I hope you can too. Don't give up!!! If I can help any further please let me know and if anyone has any suggestions for me I would love to hear from you. God Bless!
I too have been taking Cymbalta for a couple of yrs. now and with a combination of Wellbutrin and Adderall it has saved my life! It was prescribed for Fybromyalgia with Severe Depression and Chronic Fatigue.
After numerous other drugs we finally got the combination right and OMG I had my life back! I went from being so hateful I couldn't stand myself and sleeping 20 (yes 20!) hours a day, to being my normal, up beat self. This didn't just happen overnight. It took awhile to get the doseages for each med just right. I was taking 60mg Cymbalta, 450mg Wellbutrin XL, and 10mg Adderall XR daily. I had no idea how well this controlled the Fybro pain and depression and the Adderall kept me from sleeping all the time. I can't even think of any side effects I suffered. This has truely been a miracle for me. (now I need another miracle).
Expand this post...
I was put on permanent disability (social security) due to the illnesses about a year ago and recently went through a divorce and with that went my health insurance. I now find myself unable to pay for my meds due to the high cost ($1,100 a month for 3 meds!) and am going off all three cold turkey (Does any one have a gun!!! lol). Thats how I came across this website trying to find out about withdrawl (maybe the site is the mircle? God works in mysterious ways!). I'm not having the ZAPs everyone is talking about. I have never experienced them. Its the nausea, headaches from hell, and sleeping all the time (again). And did I mention I am eating anything that isn't nailed down? I've gained 12 lbs in two months and never gained while I was on the meds. After reading about others and their withdrawl problems I feel lucky compared to most but this is AWFUL! I WANT MY DRUGS !!! I would never stop taking them if I didn't have to.
Just thought I would share - I know everything works differently on everyone but I just thought I would let you know I found light at the end of the tunnel and I hope you can too. Don't give up!!! If I can help any further please let me know and if anyone has any suggestions for me I would love to hear from you. God Bless!
SORRY I hit the send button twice!