What is the mechanism of action of fondaparinux?
Answers (1)
suzanne6628 Sep 2011
Fondaparinux is an anticoagulant (blood thinner) that prevents the formation of blood clots.
This from http://www.drugs.com/pro/fondaparinux-sodium.html - scroll down to clinical pharmacology
"... The antithrombotic activity of Fondaparinux Sodium is the result of antithrombin III (ATIII)-mediated selective inhibition of Factor Xa. By selectively binding to ATIII, Fondaparinux Sodium potentiates (about 300 times) the innate neutralization of Factor Xa by ATIII. Neutralization of Factor Xa interrupts the blood coagulation cascade and thus inhibits thrombin formation and thrombus development.
Fondaparinux Sodium does not inactivate thrombin (activated Factor II) and has no known effect on platelet function. At the recommended dose, Fondaparinux Sodium does not affect fibrinolytic activity or bleeding time."
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