14 Nov 2011
Zanaflex (tizanidine) shows up in your system as tizanidine and its metabolites (none of which are active). Tizanidine is extensively metabolized,
with the two major metabolites of tizanidine having been
identified as DS-200-717 (metabolite 3, guanidine, [(5-chloro-4-(2-
imidazolin-4-on-2-ylamino)-2,1,3-benzothiazdiazole] and DS-201-
341 (metabolite 4, amide, [5-chloro-4-(guanidino)-2,1,3-benzothiazdiazole]).
Pharmacokinetics, Metabolism and Excretion
Tizanidine has linear pharmacokinetics over a dose of 1 mg to 20 mg. Tizanidine has a half-life of approximately 2.5 hours (CV = 33%). Approximately 95% of an administered dose is metabolized. The primary cytochrome P450 isoenzyme involved in tizanidine metabolism is CYP1A2. Tizanidine metabolites are not known to be active; their half-lives range from 20 to 40 hours.
- Zanaflex Information for Consumers
- Zanaflex Information for Healthcare Professionals (includes dosage details)
- Side Effects of Zanaflex (detailed)
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I have been on alot of medications in the past to try and help my pain, but all of it is just to strong, I have come back to the Lortab every time, I ...
4 answers • 28 Sep 2009
im taking zanaflex 4mg and i have a drug pee test coming up and i can have no narcotics in my system even ones that are prescribed. is this a ...
3 answers • 9 Jan 2010
2 answers • 1 Nov 2012
I have myself spasm's in my legs and have been taken zanaflex 4mg for years now my doctor changed me to valum and I felt like my head was ...
0 answers • 6 Oct 2013