My husband's dose is 80mg three times per day for chronic back pain. He has developed severe peripheral edema and have had multiple test. Kidney doctor he was referred to completed 24hr urine and no protein was evident. No ones can figure out this edema, but I found online that between !% and 5% of people who take OxyContin have this side effect. The doctors have not mentioned this as a potential cause. His history includes peripheral vascular disease, they have covered that area but say it is not related to this edema.