I've had complete hysterectomy, 1983, have been on Vivelle for 20 years, when I try to get off of it I have emotional effects of severe crying and nervousness. Have had chronic pain and depression from said pain, on antidepressant, or namely Effexor since 1986. I'm 68 years old, diabetic, and have no side effects of continued use of Vivelle, am active and younger than my years in mind and body. Thanks Linda