need to no what prophylactic treatment one should give to those who came into contact with someone who has isoniazid resistant tb?
8 Aug 2005
For close contacts of patients with pulmonary TB, apart from the 9 month isoniazid treatment, 4 months of daily rifampicin can be used if close lab monitoring is available or 2 months of treatment with rifampicin and pyrazinamide (watch out for hepatotoxicity) or 3 months of isoniazid and rifampicin are other options.
But note the strong association of rifampicin resistance and isoniazid resistane, implying that the bacteria may be resistant to rifampicin too.
Hope this could help. :)
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