This is day 3 for my husband on Amitriptyline 50 mg for migraine prevention. He is very tired and we're wanting to know if this is normal and/or how long this will take to subside as it is difficult for him to function like this?
27 Mar 2011
It could take a while... (This is why amitryptyline is no longer used as a primary treatment for depression. Of course, the doses for depression were often higher than 150mg.)
He is experiencing what's called anticholinergic side effects. There are a few ways to deal with this. First, talk to the doctor about reducing the dosage to 25mg at bedtime for a few weeks..
If that doesn't help, and the drowsiness, blurred vision, and dry mouth persist, discuss with the doctor changing the drug to another one that increases serotonin levels, such as an SSRI like Prozac.
Please do not despair; there are many other prophylactic treatments for migraines if the side effects are intolerable... but I think that dosage reduction may help a lot.
This is my OPINION, and you should rely on the doctor to make the actual decision...
3 Apr 2011
This is a common side effect, & can take awhile to subside. Does he take it in the morning or at bedtime? That can make a big difference. Has he tried or can he use other meds like Immitrex or Axert for Migraines? I suffered with migraines for 30 years & had a very bad one coinciding with a doctor appt. He could tell I had a bad headache & when I told him I had migraines for weeks on end, he gave me a shot of Immitrex. Within 15 minutes the headaches that I had had for 3 weeks 24/7 was gone. As I used the shots at home, each time I had a headache & used a shot the headaches got further & further apart until I no longer have them. Now it's my understanding that they don't make Immitrex shots anymore, but someone on here said Axert is about the same thing. I wish you well & hope he can find an answer...
4 Sep 2014
I'll be honest with you, I've been on endep 25 for about 4 months and I am still exhausted every single day. I also suffer from a lot of the side effects such as hallucinations, light headedness, confusion and a lack of concentration just to name a few . I have found a way to skip around the exhaustion most mornings and that is to eat as soon as you get up. This works 5 out of 7 days but some days I still have to go back to bed even after getting 9 hours. Try the eating thing, stuff high in sugar seems to work best. I've found that eating a mini bar of chocolate kicks my body into working order within a few minutes. Give it a go and I hope it works for him.
- Amitriptyline Information for Consumers
- Amitriptyline Information for Healthcare Professionals (includes dosage details)
- Side Effects of Amitriptyline (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
Does anyone else take three different prescriptions to manage the pain of migraines? The neurologist
... has me taking 100 mg Topamax and 25 mg amitriptyline to prevent migraine frequency. I also take Axert to manage the pain of migraines, since OTC ...
3 answers • 24 Jul 2010
Is it fairly normal for a doctor to put a person on three different prescriptions to treat migraine?
frequency and pain? The neurologist has me taking 100 mg Topamax and 25 mg amitriptyline to "prevent" migraines. However, I do not think ...
7 answers • 24 Jul 2010
Started taking 10mg Amitriptyline for migraine prevention. I am already taking Citalopram 20mg, but?
... the doctor assured me it would be fine since they are such low doses. The first two nights the only side effect I noticed was the sensation of ...
2 answers • 26 Jul 2013
I have been taking amitriptyline for 2 days now, for vestibular migraine preventative & depression.?
... How long should i expect to feel drowsy and woozy, like im floating on my feet when I walk and kind of unsteady? I get dizziness, ...
2 answers • 4 Dec 2014