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FDA Medwatch Alert: Zofran (ondansetron): Drug Safety Communication - Risk of Abnormal Heart Rhythms
Posted 15 Sep 2011 by Drugs.com
ISSUE: FDA notified healthcare professionals and patients of an ongoing safety review and labeling changes for the anti-nausea drug Zofran (ondansetron, ondansetron hydrochloride and generics). Ondansetron may increase the risk of developing prolongation of the QT interval of the electrocardiogram, which can lead to an abnormal and potentially fatal heart rhythm, including Torsade de Pointes. Patients at particular risk for developing Torsade de Pointes include those with underlying heart conditions, such as congenital long QT syndrome, those who are predisposed to low levels of potassium and magnesium in the blood, and those taking other medications that lead to QT prolongation. BACKGROUND: Zofran (ondansetron) is in a class of medications called 5-HT3 receptor antagonists. It is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy and surgery. FDA is ... Read more
Related support groups: Zofran, Ondansetron, Zofran ODT, Zuplenz
Nausea Drug Shows Promise Against Opioid Addiction
Posted 18 Feb 2009 by Drugs.com
WEDNESDAY, Feb. 18 – A drug currently used to treat nausea can prevent symptoms of withdrawal from illegal and prescription opioid drugs such as heroin, morphine and codeine, a new study shows. The Stanford University scientists behind the research added it can do so without some of the serious side effects caused by existing treatments for addiction to these drugs. Initial tests in mice showed that the drug ondansetron (Zofran) blocks certain 5-HT3 receptors involved in withdrawal symptoms, the researchers said. They then tested it in eight healthy, non-opioid-dependent volunteers who were given two doses of morphine, once without ondansetron and one with it, and found ondansetron reduced withdrawal symptoms in humans. The study appears in the Feb. 17 online issue of the Journal of Pharmacogenetics and Genomics. "Opioid abuse is rising at a faster rate than any other type of illicit ... Read more
Related support groups: Opiate Withdrawal, Zofran
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Related Condition Support Groups
Nausea/Vomiting, Nausea/Vomiting -- Chemotherapy Induced, Nausea/Vomiting -- Postoperative, Alcohol Dependence, Gastroenteritis, Obsessive Compulsive Disorder, Nausea/Vomiting -- Radiation Induced, Postanesthetic Shivering, Pruritus