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Statins Before Vascular Surgery Cut Deaths, Complications
Posted 18 Jan 2010 by Drugs.com
WEDNESDAY, Sept. 2 – A dose of a cholesterol-lowering statin before vascular surgery reduces the risk of complications and death, new Dutch research shows. The study of nearly 500 patients who had surgery for a variety of blood-vessel problems found the incidence of heart artery blockage and deaths was halved in those who received an 80-milligram dose of fluvastatin before their operation, compared to those given a placebo. "The manuscript showed that fluvastatin extended-release is safe in the perioperative period, associated with a reduced inflammatory status and improved outcome, compared to placebo," said Dr. Don Poldermans, a professor of internal medicine at Erasmus Medical Center in Rotterdam, the Netherlands, and a principal author of a report in the Sept. 3 issue of the New England Journal of Medicine. Heart artery blockage occurred in 10.8 percent of the people who received ... Read more
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