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Does Long-Term Acetaminophen Use Raise Health Risks?

Posted 1 day 5 hours ago by Drugs.com

MONDAY, March 2, 2015 – Acetaminophen may not be as safe as previously thought, with larger doses and long-term use linked to increased risk of health problems, a new report contends. Best known in the United States under the brand name Tylenol, acetaminophen is the most widely used painkiller in the world, the study authors said in background notes. It is the World Health Organization's front-line treatment for pain, and is considered safer than nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen, the researchers said. But a small group of studies has raised questions about acetaminophen's safety if used for a long time and at high doses to treat chronic pain, said lead author Dr. Philip Conaghan, a professor with the Leeds Institute of Rheumatic and Musculoskeletal Medicine in England. Heavy use of acetaminophen is associated with kidney disease and bleeding ... Read more

Related support groups: High Blood Pressure, Percocet, Vicodin, Bleeding Disorder, Norco, Hypertension, Tylenol, Lortab, Acetaminophen, Ischemic Stroke, Fioricet, Paracetamol, Endocet, Darvocet-N 100, Excedrin, Tylenol PM, NyQuil, Acetaminophen/Hydrocodone, Chronic Kidney Disease, Ultracet

FDA Medwatch Alert: Prescription and Over-the-Counter (OTC) Pain Medicines: Drug Safety Communication - FDA Review of Possible Risks of Pain Medicine Use During Pregnancy

Posted 20 Jan 2015 by Drugs.com

[Posted 01/09/2015] ISSUE:  FDA is aware of and understands the concerns arising from recent reports questioning the safety of prescription and over-the-counter (OTC) pain medicines when used during pregnancy. As a result, FDA evaluated research studies published in the medical literature and determined they are too limited to make any recommendations based on these studies at this time. Because of this uncertainty, the use of pain medicines during pregnancy should be carefully considered. FDA urges pregnant women to always discuss all medicines with their health care professionals before using them. Severe and persistent pain that is not effectively treated during pregnancy can result in depression, anxiety, and high blood pressure in the mother. Medicines including nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen can help treat severe and persistent pain. ... Read more

Related support groups: Pain, Tylenol, Acetaminophen, Ibuprofen, Naproxen, Advil, Aleve, Paracetamol, Motrin, Panadol, Naprosyn, Naprelan '375', Naprelan, Tylenol Extra Strength, Panadol Osteo, Q-Pap, Tylenol Arthritis Caplet, Childrens Tylenol, Anaprox, Acetaminophen Quickmelt

Knee Arthritis Drugs Beat Placebos, but Study Finds No Clear Winner

Posted 6 Jan 2015 by Drugs.com

TUESDAY, Jan. 6, 2015 – Pain-relieving treatments for knee arthritis all work better than doing nothing – but it's hard to point to a clear winner, a new research review concluded. Using data from almost 140 studies, researchers found all of the widely used arthritis treatments – from over-the-counter painkillers to pain-relieving injections – brought more relief to aching knees over three months than did placebo pills. But there were some surprises in the study, according to lead researcher Dr. Raveendhara Bannuru, of Tufts Medical Center in Boston. Overall, the biggest benefit came from injections of hyaluronic acid (HA) – a treatment some professional medical groups consider only marginally effective. Hyaluronic acid is a lubricating substance found naturally in the joints. Over the years, studies have been mixed as to whether injections of synthetic HA help arthritic joints, ... Read more

Related support groups: Osteoarthritis, Tylenol, Acetaminophen, Ibuprofen, Naproxen, Meloxicam, Diclofenac, Advil, Voltaren, Mobic, Aleve, Paracetamol, Cortisone, Motrin, Toradol, Indomethacin, Etodolac, Nabumetone, Orthovisc, Flector

No Link Between Acetaminophen in Pregnancy, Asthma in Kids: Study

Posted 26 Nov 2014 by Drugs.com

WEDNESDAY, Nov. 26, 2014 – Taking acetaminophen, best known as Tylenol, during pregnancy or giving it to young children does not raise the risk of childhood asthma, a new study finds. Concerns have been raised that the use of acetaminophen during pregnancy and/or early in a child's life may be associated with the development of asthma. But the study authors say that respiratory infections during infancy probably play a much more significant role in the later development of asthma, and there's no need to change current recommendations about the use of acetaminophen. The study was led by Dr. Adrian Lowe at the University of Australia, in Melbourne. His team analyzed data from 11 studies conducted on the potential link between the use of acetaminophen by pregnant women and during the first two years of a child's life – a critical time in the development of young lungs. While the studies ... Read more

Related support groups: Percocet, Vicodin, Norco, Tylenol, Lortab, Asthma, Acetaminophen, Fioricet, Paracetamol, Endocet, Darvocet-N 100, Excedrin, Tylenol PM, NyQuil, Acetaminophen/Hydrocodone, Ultracet, Tylenol with Codeine, Percocet 10/325, Roxicet, Tylenol with Codeine 3

Acetaminophen May Not Help Against Back Pain, Study Contends

Posted 23 Jul 2014 by Drugs.com

WEDNESDAY, July 23, 2014 – Even though its use is often advised by doctors, the painkiller acetaminophen – best known as Tylenol – does not help treat lower back pain, according to a new Australian study. The researchers found the drug was no more effective than a dummy pill for more than 1,600 people suffering from acute lower back pain. Besides showing no effect in easing discomfort, the study also found the drug was no help in improving sleep woes tied to back pain, nor did it improve patients' overall quality of life. The research team said the findings call into question the belief that acetaminophen should be the first choice when treating this common form of back pain. The drug "might not be of primary importance in the management of acute lower back pain," study lead author Dr. Christopher Williams from the George Institute for Global Health at the University of Sydney in ... Read more

Related support groups: Back Pain, Tylenol, Acetaminophen, Paracetamol, Panadol, Tylenol Extra Strength, Panadol Osteo, Q-Pap, Tylenol Arthritis Caplet, Acetaminophen Quickmelt, Childrens Tylenol, Perfalgan, Aceta, Panamax, Lemsip Max, Altenol, Q-Pap Extra Strength, Buckleys Complete, Tylenol Arthritis Pain, Bromo Seltzer

Spoon Measurements Behind Many Child Drug-Dosing Errors: Study

Posted 14 Jul 2014 by Drugs.com

MONDAY, July 14, 2014 – Using a teaspoon or tablespoon to administer kids' medications can often lead to medication dosing errors, a new study reports. Teaspoon- or tablespoon-based medicine instructions doubled a parent's chances of incorrectly measuring the intended dosage, and also doubled the risk they would not accurately follow the doctor's prescription, the study authors found. "A move to a milliliter preference for dosing instructions for liquid medications could reduce parent confusion and decrease medication errors, especially for groups at risk for making errors, such as those with low health literacy and non-English speakers," said the study's lead author Dr. Shonna Yin, an assistant professor of pediatrics at NYU School of Medicine in New York City. Findings from the study were published online July 14 and in the August print issue of Pediatrics. More than 10,000 annual ... Read more

Related support groups: Tylenol, Acetaminophen, Paracetamol, Panadol, Pain/Fever, Tylenol Extra Strength, Panadol Osteo, Q-Pap, Tylenol Arthritis Caplet, Acetaminophen Quickmelt, Childrens Tylenol, Perfalgan, Aceta, Panamax, Lemsip Max, Altenol, Q-Pap Extra Strength, Buckleys Complete, Tylenol Arthritis Pain, Bromo Seltzer

Common Cold Meds May Pose Health Threats

Posted 19 Mar 2014 by Drugs.com

WEDNESDAY, March 19, 2014 – Over-the-counter sinus and pain remedies that combine two common ingredients – phenylephrine and acetaminophen – might cause serious side effects such as high blood pressure, dizziness and tremors, New Zealand researchers warn. These side effects occur because acetaminophen (the main ingredient in Tylenol) boosts the effects of phenylephrine, according to a report in the March 20 issue of the New England Journal of Medicine. Products containing this drug combination include Tylenol Sinus, Sudafed PE Sinus, Benadryl Allergy Plus Sinus and Excedrin Sinus Headache. "What we found was surprising because it hasn't been studied or reported," said lead researcher Hartley Atkinson, managing director of AFT Pharmaceuticals, Ltd., in Auckland. Phenylephrine, which replaced pseudoephedrine in many over-the-counter medications, relieves nasal congestion from colds, ... Read more

Related support groups: Percocet, Vicodin, Norco, Tylenol, Lortab, Acetaminophen, Sta-D, Fioricet, Paracetamol, Endocet, Darvocet-N 100, Excedrin, Cold Symptoms, Tylenol PM, NyQuil, Phenylephrine, Acetaminophen/Hydrocodone, Ultracet, Tylenol with Codeine, Alka-Seltzer

Use of Tylenol in Pregnancy Tied to Higher ADHD Risk in Child

Posted 24 Feb 2014 by Drugs.com

MONDAY, Feb. 24, 2014 – Expectant mothers suffering from fever or headache may face a new dilemma when they open the medicine cabinet. Pregnant women who take acetaminophen – best known under the brand name Tylenol – might be more likely to have a child with attention deficit-hyperactivity disorder (ADHD), a new long-term study suggests. Acetaminophen is the most commonly used over-the-counter medication for pregnant women who experience fever or pain. Children whose mothers took acetaminophen while pregnant had up to a 40 percent higher risk of being diagnosed with ADHD, according to the research, which involved more than 64,000 Danish mothers and their children. The kids were born between 1996 and 2002. By the age of 7, these children also were more likely to use ADHD medication and exhibit ADHD-like behavior problems, according to the study, published Feb. 24 in the journal JAMA ... Read more

Related support groups: Attention Deficit Hyperactivity Disorder (ADHD), Percocet, Vicodin, Norco, Tylenol, Lortab, Acetaminophen, Fioricet, Paracetamol, Endocet, Darvocet-N 100, Excedrin, Tylenol PM, NyQuil, Acetaminophen/Hydrocodone, Ultracet, Tylenol with Codeine, Percocet 10/325, Roxicet, Tylenol with Codeine 3

FDA Warns Against Prescription Drugs With High Levels of Acetaminophen

Posted 15 Jan 2014 by Drugs.com

WEDNESDAY, Jan. 15, 2014 – The U.S. Food and Drug Administration has asked doctors to stop prescribing painkillers that contain more than 325 milligrams of acetaminophen because of reports of severe liver damage. Prescription painkillers, which include Vicodin and Percocet, are commonly given for pain following acute injuries, operations or dental procedures and they often contain acetaminophen. However, many over-the-counter medications also contain acetaminophen. The FDA first tackled this issue in January 2011, when it asked drug makers to stop making prescription painkillers that contained more than 325 milligrams of acetaminophen per dose. Accidental overdoses from using these products contributes to nearly half of all cases of acetaminophen-related liver failure in the United States, the agency said in a statement issued Tuesday. Most cases of severe liver injury occurred in ... Read more

Related support groups: Percocet, Vicodin, Norco, Tylenol, Lortab, Acetaminophen, Fioricet, Paracetamol, Endocet, Darvocet-N 100, Excedrin, Tylenol PM, NyQuil, Acetaminophen/Hydrocodone, Ultracet, Tylenol with Codeine, Percocet 10/325, Roxicet, Tylenol with Codeine 3, Panadol

FDA Medwatch Alert: Acetaminophen Prescription Combination Drug Products with more than 325 mg: FDA Statement - Recommendation to Discontinue Prescribing and Dispensing

Posted 14 Jan 2014 by Drugs.com

ISSUE: FDA is recommending health care professionals discontinue prescribing and dispensing prescription combination drug products that contain more than 325 milligrams (mg) of acetaminophen per tablet, capsule or other dosage unit. There are no available data to show that taking more than 325 mg of acetaminophen per dosage unit provides additional benefit that outweighs the added risks for liver injury. Further, limiting the amount of acetaminophen per dosage unit will reduce the risk of severe liver injury from inadvertent acetaminophen overdose, which can lead to liver failure, liver transplant, and death.   Cases of severe liver injury with acetaminophen have occurred in patients who: • took more than the prescribed dose of an acetaminophen-containing product in a 24-hour period; • took more than one acetaminophen-containing product at the same time; or • drank alcohol while taking a ... Read more

Related support groups: Pain, Percocet, Vicodin, Norco, Tylenol, Lortab, Acetaminophen, Fever, Fioricet, Paracetamol, Endocet, Darvocet-N 100, Excedrin, Tylenol PM, NyQuil, Acetaminophen/Hydrocodone, Ultracet, Tylenol with Codeine, Percocet 10/325, Roxicet

Health Tip: Don't Take Too Much Acetaminophen

Posted 3 Jan 2014 by Drugs.com

-- If you're plagued with a headache, sinus congestion or body aches, you may find the common pain reliever acetaminophen in more than one medication you take for relief. After all, acetaminophen is found in more than 600 over-the-counter and prescription medications, the U.S. Food and Drug Administration says. The FDA makes these recommendations on how to make sure you don't take too much acetaminophen, the active ingredient in Tylenol: Adults should not exceed 4,000 milligrams per day. Never take more than the recommended dose of any medication. Avoid taking multiple over-the-counter medications that contain acetaminophen. Don't take a prescription drug that contains acetaminophen along with an OTC medication that contains it. Read more

Related support groups: Headache, Percocet, Vicodin, Norco, Tylenol, Lortab, Acetaminophen, Fioricet, Paracetamol, Endocet, Darvocet-N 100, Excedrin, Cold Symptoms, Tylenol PM, NyQuil, Acetaminophen/Hydrocodone, Ultracet, Tylenol with Codeine, Percocet 10/325, Roxicet

Tylenol and Alcohol a Bad Mix, Study Suggests

Posted 4 Nov 2013 by Drugs.com

MONDAY, Nov. 4 – Combining Tylenol and even light consumption of alcohol can more than double someone's risk of kidney disease, researchers say. Taking the recommended dose of Tylenol, also known by its generic name acetaminophen, combined with a small to moderate amount of alcohol produces a 123 percent increased risk of kidney disease, according to a new preliminary study. "Most people take this medication without any input from pharmacists or physicians, and that's where the public-health concern is," said lead researcher Harrison Ndetan, an associate professor for research and biostatistics at Parker University in Dallas. "People buy acetaminophen over the counter, and they also are casual alcohol users, and they don't know that there is a harmful interaction." The study, scheduled for presentation Monday at the American Public Health Association's annual meeting in Boston, ... Read more

Related support groups: Percocet, Vicodin, Norco, Tylenol, Lortab, Acetaminophen, Fioricet, Paracetamol, Endocet, Darvocet-N 100, Excedrin, Tylenol PM, NyQuil, Acetaminophen/Hydrocodone, Ultracet, Tylenol with Codeine, Percocet 10/325, Roxicet, Tylenol with Codeine 3, Panadol

FDA Medwatch Alert: Perrigo Acetaminophen Infant Suspension Liquid: Recall - Potential Defect with Co-packaged Oral Syringe

Posted 3 Nov 2013 by Drugs.com

ISSUE: The Perrigo Company announced that it has initiated a voluntary, nationwide product recall to the retail level of 18 batches of its acetaminophen infant suspension liquid, 160 mg/5 mL, sold in 2 oz. and 4 oz. bottles with syringes in a box under store brand products including Babies R Us, Care One and more  (refer to the Firm Press Release for full list of affected brand names and products). The recall is being initiated because of the remote potential that a small number of packages might contain an oral dosing syringe without dose markings. Using an oral syringe without dose markings can result in inaccurate dosing, especially in infants who could mistakenly get too high a dose. BACKGROUND:  This over the counter product is indicated for the relief of fever and minor aches and pains and can be used in infants, children and adults. These recalled products are sold by d ... Read more

Related support groups: Tylenol, Acetaminophen, Paracetamol, Panadol, Tylenol Extra Strength, Panadol Osteo, Q-Pap, Tylenol Arthritis Caplet, Acetaminophen Quickmelt, Childrens Tylenol, Perfalgan, Aceta, Panamax, Lemsip Max, Q-Pap Extra Strength, Altenol, Buckleys Complete, Tylenol Arthritis Pain, Bromo Seltzer, Paracets

After Tonsillectomy, Over-the-Counter Painkillers Suffice, Study Says

Posted 3 Oct 2013 by Drugs.com

THURSDAY, Oct. 3 – An over-the-counter painkiller is as effective as prescription drugs in controlling pain after people have their tonsils removed, a new study suggests. Researchers looked at 25 children and adults and found that ibuprofen (Advil, Motrin) managed their pain after tonsillectomy as well as the prescription pain medications acetaminophen (Tylenol) with hydrocodone, and acetaminophen with codeine, which is no longer recommended for use in children. "Based on this study and the FDA warning about the risks of children taking any medication with codeine, we recommend that children receive over-the-counter ibuprofen after a tonsillectomy," study author Dr. Robert Standring, in the department of otolaryngology-head and neck surgery at Henry Ford Health System in Detroit, said in a system news release. In 2012, the U.S. Food and Drug Administration recommended that children not ... Read more

Related support groups: Surgery, Tylenol, Acetaminophen, Ibuprofen, Advil, Tonsillitis/Pharyngitis, Paracetamol, Motrin, Panadol, Tylenol Extra Strength, Panadol Osteo, Q-Pap, Acetaminophen Quickmelt, Tylenol Arthritis Caplet, Childrens Tylenol, Perfalgan, Aceta, Panamax, Lemsip Max, Advil Migraine

Tylenol to Come With New Warning

Posted 4 Sep 2013 by Drugs.com

September 3, 2013 – Caps on bottles of the popular pain reliever Tylenol that are sold in the United States will soon come with warnings alerting consumers to the potential for liver failure and even death, the Associated Press reported Thursday. The warning will state that Tylenol's active ingredient is acetaminophen, the nation's leading cause of sudden liver failure. The new cap is designed to alert consumers who may not read similar warnings that already appear in small print on the product's label, the AP said. In addition to Tylenol, acetaminophen is contained in more than 600 over-the-counter products used by nearly one in four American adults every week. Those other products include such popular brands as Nyquil cold formula, Excedrin pain tablets and Sudafed sinus pills, the AP reported. Tylenol's maker, Johnson & Johnson, said the warning will appear on the cap of each new ... Read more

Related support groups: Vicodin, Norco, Tylenol, Lortab, Acetaminophen, Fioricet, Paracetamol, Excedrin, Darvocet-N 100, Tylenol PM, NyQuil, Acetaminophen/Hydrocodone, Ultracet, Tylenol with Codeine, Tylenol with Codeine 3, Panadol, Coricidin, DayQuil, Lorcet 10/650, Tylenol Cold

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