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Can Testosterone Therapy Help Obese Men Lose Weight?

Posted 19 days ago by Drugs.com

WEDNESDAY, May 9 – Older obese men with low levels of testosterone can lose weight when levels of the male hormone are restored to normal, a new study suggests. But it might not be the testosterone itself. Rather, it could be that men undergoing the hormone therapy feel better and stronger so they exercise more and watch their diet, speculated experts not involved with the study. "It [the study's conclusion] is overly optimistic," said Dr. Bradley Anawalt, a spokesman for The Endocrine Society and chief of medicine at the University of Washington Medical Center in Seattle. "There is very little evidence that testosterone should cause weight loss in men obese or otherwise; it usually results in weight gain." Anawalt, who was not involved in the study, noted the study was sponsored by Bayer, which makes testosterone supplements. "If you were a drug company, the best product in the world ... Read more

Testosterone Supplements Might Help Patients With Heart Failure

Posted 17 Apr 2012 by Drugs.com

TUESDAY, April 17 – Patients struggling with moderate to severe heart failure might benefit from testosterone supplementation to boost their ability to exercise, new Canadian research suggests. But it's far too soon to recommend testosterone as a therapy for heart failure patients, a cardiology expert warned. The research team analyzed four randomized studies, conducted between 1980 and 2010, which had examined the potential benefit of treating heart failure patients with testosterone supplementation. "Heart failure is a chronic condition that can be brought on by blockages in the heart, lung disease, diabetes or kidney disease," said study co-author Justin Ezekowitz, an assistant professor in the department of cardiology at the University of Alberta as well as at the Mazankowski Alberta Heart Institute, both in Edmonton. "It's a clinical syndrome, where the body can not pump enough ... Read more

BioSante Pharmaceuticals Announces FDA Approval for Bio-T-Gel

Posted 15 Feb 2012 by Drugs.com

LINCOLNSHIRE, Ill.--(BUSINESS WIRE)--Feb 15, 2012 - BioSante Pharmaceuticals, Inc. today announced that the U.S. Food and Drug Administration (FDA) has approved Bio-T-Gel, which is licensed by BioSante to Teva Pharmaceuticals USA, Inc. Bio-T-Gel is a testosterone gel for the treatment of male hypogonadism or low testosterone levels. Male hypogonadism is generally characterized by impotence, a lack of sex drive, muscle weakness and osteoporosis. Bio-T-Gel was initially developed by BioSante, and then it was licensed to Teva for late stage clinical development. Teva is responsible for all Bio-T-Gel regulatory and marketing activities. BioSante will receive royalties and may receive certain milestone payments upon commercialization of Bio-T-Gel. The current U.S. market for male testosterone products is estimated at over $1.6 billion. “We are pleased that Bio-T-Gel will provide another t ... Read more

Related support groups: Testosterone, Hypogonadism -- Male

Age Alone May Not Cause Testosterone to Fall

Posted 7 Jun 2011 by Drugs.com

TUESDAY, June 7 – Testosterone levels don't necessarily drop with age, but it's more likely among older men with declining general health, a new study suggests. Bucking prior research indicating age-related testosterone deficiency contributes to deteriorating health, fatigue and libido loss, Australian researchers found that blood testosterone amounts didn't fall in older men with optimal health. The data, gathered as part of the Healthy Man Study, is scheduled to be presented Tuesday at the Endocrine Society's annual meeting in Boston. "Our interpretation is that age in and of itself does not reduce blood testosterone levels . . . but the accumulating disorders as men age, some preventable and some not, some genetic and some environmental, do have such an impact, albeit pretty modest," said study author Dr. David Handelsman, a professor of reproductive endocrinology and andrology at ... Read more

Endo Pharmaceuticals Receives FDA Approval for Fortesta (Testosterone) Gel as a Class III Product for Topical Use for Men With Low Testosterone

Posted 3 Jan 2011 by Drugs.com

CHADDS FORD, Pa., Dec. 29, 2010 /PRNewswire via COMTEX/ --Endo Pharmaceuticals today announced that the U.S. Food and Drug Administration (FDA) has approved Fortesta Gel for the treatment of low testosterone, or 'Low T,' also known as hypogonadism. Symptoms associated with Low T include erectile dysfunction and decreased sexual desire, fatigue and loss of energy, mood depression, regression of secondary sexual characteristics and osteoporosis. Low T is a condition that has an estimated prevalence in nearly 14 million men in the United States, yet only about 1.3 million, (9 percent) are currently being treated. Endo Pharmaceuticals expects to introduce Fortesta Gel in the United States in early 2011. "Declining blood levels of testosterone can occur in men beginning as early as age 40. The symptoms of low testosterone can be non-specific and often associated with other chronic medical ... Read more

Related support groups: Testosterone, Hypogonadism -- Male

Low Testosterone May Raise Risk of Early Death: Study

Posted 19 Oct 2010 by Drugs.com

TUESDAY, Oct. 19 – Men with low testosterone levels may be at increased risk for premature death from heart disease and all causes, a finding that challenges the current belief that testosterone is a risk factor for cardiovascular disease, according to new research. The study included 930 men with coronary artery disease who were followed-up for about seven years. At the start of the study, low testosterone levels were noted in about one-quarter of the men. During the study period, one in five men (20 percent) with low testosterone levels died, compared with one in eight (12 percent) of those with normal levels of the hormone, according to the report in the Oct. 20 online edition of the journal Heart. After taking into account other risk factors – such as age, co-existing health problems, smoking and weight – a low testosterone level was found to be an independent risk factor for ... Read more

Testosterone Could Boost Health of Heart Failure Patients

Posted 5 Oct 2010 by Drugs.com

TUESDAY, Oct. 5 – A small new study is the latest to suggest that testosterone may boost the health of women with heart failure, without causing serious side effects. Researchers aren't yet ready to recommend that their colleagues start prescribing the hormone to female patients. However, the treatment does hold some promise, especially considering the limits of current medicine when it comes to heart failure, said cardiologist Justin A. Ezekowitz, who wrote a commentary about the findings. "They're definitely onto something that deserves explanation," said Ezekowitz, an assistant professor at the University of Alberta in Canada. "We have a hit a wall in terms of what we can do for patients with heart failure. We've made a lot of progress, but there are still patients who have symptoms despite the premium blend of medications and fancy devices." Heart failure is most common in people ... Read more

Testosterone Gel Could Raise Heart Risks in Frail, Older Men

Posted 30 Jun 2010 by Drugs.com

WEDNESDAY, June 30 – Older men in poor health who use testosterone gel to boost their mobility may raise their odds of high blood pressure or heart attack, new research suggests. The problems observed were concerning enough to cause the researchers to put an early stop to the study, which is published in the July 1 issue of the New England Journal of Medicine. However, the trial was a small one and volunteers were older men with diabetes, cardiovascular disease and other problems, so whether or not these adverse events would affect the larger population of men taking testosterone therapy is still an open question. Furthermore, the testosterone doses used in this study were higher than often seen in doctors' offices and other trials, the authors noted. "These results were a caution flag but not a red light about stopping treatment," said Dr. Evan Hadley, director of the division of ... Read more

Testosterone May Make Women Less Trusting

Posted 24 May 2010 by Drugs.com

MONDAY, May 24 – It turns out that testosterone might be responsible for more than masculinity and Hollywood action movies: A new study suggests that women who get doses of the hormone are less trusting of strangers, a possible sign that testosterone boosts levels of caution. The research doesn't prove a direct connection between testosterone, which is found in both sexes. But it does appear to indicate that the hormone helps reduce trust in women and, "in our opinion, protects them from harm," said study co-author Jack van Honk, a psychologist at Utrecht University in the Netherlands. The overall role of testosterone in the body remains something of a mystery. "We don't know a lot, to be completely honest," said Paola Sapienza, a professor of finance at Northwestern University who studies testosterone and how it affects decision-making. The hormone seems to be connected to aggression, ... Read more

Testosterone Therapy May Help Men With Heart Failure

Posted 12 Jan 2010 by Drugs.com

MONDAY, Aug. 24 – Injections of the male hormone testosterone increased blood-pumping ability and heart muscle strength in men with heart failure, Italian researchers report. "From our study, it appears that testosterone supplementation is useful for both patients with low and normal testosterone levels, although the improvements are greater in those with low levels," said Dr. Ferdinando Iellamo, an assistant professor of internal medicine at the University of Rome Tor Vergata, and lead author of a report in the Sept. 1 issue of the Journal of the American College of Cardiology. Use of testosterone for heart failure, the progressive loss of the ability to pump blood throughout the body, has been controversial in some cases. About one of every four men with chronic heart failure has evidence of testosterone deficiency, as production of the hormone declines with age. Few studies of ... Read more

Testosterone Gets Bad Rap: Study

Posted 9 Dec 2009 by Drugs.com

TUESDAY, Dec. 8 – People associate testosterone with aggressiveness, but the male sex hormone actually encourages a sense of fair play, a new study finds. Testosterone does not cause aggression, said lead researcher Michael Naef, of the department of economics at Royal Holloway, University of London. But it does lead to "status-seeking behavior – or trying to secure one's own status," he said. Such status-seeking behavior can include aggression, as well as other behaviors appropriate to particular situations, the researchers said. But they also found that people's preconceptions about testosterone, rather than the hormone itself, may cause them to behave anti-socially and unfairly. For the study, Naef's team randomly assigned 121 women to receive testosterone or a placebo. The women then participated in an experiment where they were asked to distribute money. The money could be ... Read more

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