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Schizophrenia Blog

Related terms: Catatonic Schizophrenia, Disorganized Schizophrenia, Paranoid Schizophrenia, Residual Schizophrenia, Schizophrenia, catatonic, Schizophrenia, disorganized, Schizophrenia, paranoid, Schizophrenia, residual, Schizophrenia, undifferentiated, Undifferentiated Schizophrenia

Gene Discoveries Could Shed New Light on Schizophrenia

Posted 8 days ago by Drugs.com

TUESDAY, July 22, 2014 – One of the largest studies ever conducted into the genetic origins of a psychiatric disorder has uncovered 83 new sites on chromosomes that harbor inherited genes tied to schizophrenia. The findings, made by an international team of researchers, now bring the total number of common gene variants linked to the disorder to 108. Although these schizophrenia-associated genes aren't specific enough to be used as a test to predict who will or will not develop the illness, researchers say they might someday be used as a screening tool for high-risk people who may benefit from preventative treatments. Right now, the total group of schizophrenia-linked genes "only explains only about 3.5 percent of the risk for schizophrenia," Dr. Thomas Insel, director of the U.S. National Institute of Mental Health, said in an agency news release. However, "even based on these early ... Read more

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Antipsychotics Linked to Lower Brain Volume in Schizophrenia Patients

Posted 9 days ago by Drugs.com

FRIDAY, July 18, 2014 – Antipsychotic drugs are associated with a slight decrease in both brain cells and connections between brain cells in schizophrenia patients, a new study indicates. However, this loss of what is called brain volume does not worsen schizophrenia symptoms or affect overall mental function, researchers reported in the study published online July 18 in the journal PLoS One. "It's important to stress that the loss of brain volume doesn't appear to have any effect on people over the nine-year follow-up we conducted, and patients should not stop their medication on the basis of this research," study author Dr. Graham Murray, of the Behavioral and Clinical Neuroscience Institute and the department of psychiatry at the University of Cambridge in England, said in a university news release. "A key question in future will be to examine whether there is any effect of this ... Read more

Related support groups: Seroquel, Abilify, Schizophrenia, Zyprexa, Risperdal, Geodon, Risperidone, Saphris, Seroquel XR, Latuda, Quetiapine, Olanzapine, Invega, Clozapine, Clozaril, Aripiprazole, Fanapt, Ziprasidone, Zyprexa Zydis, Asenapine

Taking Antipsychotic Drugs While Pregnant May Harm Newborns: Study

Posted 4 Jun 2014 by Drugs.com

WEDNESDAY, June 4, 2014 – Although antipsychotic medications have not been shown to cause birth defects, new research suggests these drugs can have other harmful effects on babies. Antipsychotic drugs are used to treat a range of mental illnesses, such as schizophrenia, depression and bipolar disorder. An Australian study found that babies born to women on these medications are more likely to spend time in a neonatal intensive care unit (NICU) or to need specialized care after birth. The researchers cautioned that health guidelines for the use of antipsychotic drugs during pregnancy should be clarified. "There's been little research on antipsychotic medication during pregnancy, and if it affects babies. The lack of data has made it very difficult for clinicians to say anything conclusively on how safe it is for babies," lead investigator, Jayashri Kulkarni, director of the Monash ... Read more

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Premature Death, Suicides Up Among People With Schizophrenia, Study Says

Posted 4 Jun 2014 by Drugs.com

WEDNESDAY, June 4, 2014 – People with schizophrenia are facing higher risks of dying prematurely, killing themselves and committing violent crimes compared to the general population, a new Swedish study finds. Researchers looked at nearly 25,000 adults in Sweden diagnosed with schizophrenia or related disorders over almost four decades. They found that within five years of diagnosis, one in 50 committed suicide; around 1 in 10 men was convicted of a violent offense, and overall, the odds of dying prematurely were eight times higher than for people without the mental illness. "In recent years, there has been a lot of focus on primary prevention of schizophrenia – preventing people from getting ill. While primary prevention is clearly essential and may be some decades away, our study highlights the crucial importance of secondary prevention – treating and managing the risks of adverse ... Read more

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Schizophrenia May Raise Dementia Risk in Older Adults

Posted 30 May 2014 by Drugs.com

FRIDAY, May 30, 2014 – Older adults who have schizophrenia appear to face a higher risk of getting dementia, new research suggests. "The rates of dementia in those with schizophrenia in the study were twice that of non-schizophrenic patients," said lead researcher Hugh Hendrie, a Regenstrief Institute investigator and a scientist at the Indiana University Center for Aging Research. On the other hand, while those with schizophrenia were also more likely to develop other health problems, they were less likely to get cancer. The study is published in the May issue of the American Journal of Geriatric Psychiatry. As the diagnosis and treatment of schizophrenia have improved, those with the mental illness are living longer, researchers noted. But there has been little information about how they fare with other conditions, such as heart problems and dementia, as they age. So Hendrie's team, ... Read more

Related support groups: Schizophrenia, Dementia

Newly Discovered Gene May Shed Light on Certain Brain Disorders

Posted 12 Feb 2014 by Drugs.com

WEDNESDAY, Feb. 12, 2014 – Scientists who discovered a gene that links the thickness of the brain's gray matter to intelligence say their finding might help improve understanding of brain disorders such as autism and schizophrenia. The team looked at the cerebral cortex, which is the outside layer of the human brain. It plays an important role in areas such as memory, attention, thought, language and consciousness. Previous research has shown that the thickness of the cerebral cortex is closely linked with intelligence. Until now, no genes associated with the thickness of the cerebral cortex have been identified, the study authors said. The researchers at King's College London, in England, analyzed DNA samples and MRI brain scans from nearly 1,600 healthy 14-year-olds, who also underwent tests to determine their intelligence levels. The scientists examined more than 54,000 variations ... Read more

Related support groups: Schizophrenia, Autism

Schizophrenia Linked to Pregnancy Complications, Study Suggests

Posted 6 Feb 2014 by Drugs.com

THURSDAY, Feb. 6, 2014 – Women with schizophrenia are at increased risk for serious problems during pregnancy and childbirth, according to a new study. Canadian researchers analyzed data on births in the province of Ontario from 2002 to 2011 and found that preeclampsia, preterm birth and other serious pregnancy and delivery complications were twice as likely to occur in women with schizophrenia than in those without the mental health disorder. Women with schizophrenia were more likely to develop placental abruption (in which placenta separates from the uterus) and septic shock, to undergo induced labor and cesarean section, to be transferred to an intensive care unit, and to be readmitted to the hospital after discharge. "Traditionally, women with schizophrenia have had low fertility rates, and little attention was paid to their reproductive health," study author Dr. Simon Vigod, a ... Read more

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Psychotherapy May Be Effective Alternate Treatment for Schizophrenia, Study Finds

Posted 6 Feb 2014 by Drugs.com

THURSDAY, Feb. 6, 2014 – A form of psychotherapy known as cognitive behavioral therapy may be an effective option for schizophrenia patients who are unable or unwilling to take antipsychotic drugs, a new study suggests. Reporting Feb. 6 in The Lancet, British researchers say that the treatment can help ease patients' psychotic symptoms and boost their personal and social functioning. They note that many people with schizophrenia cannot take standard medications. "As many as half of all people with schizophrenia choose not to take drugs because of side effects that can include serious weight gain, development of metabolic disorders and an increased risk of sudden cardiac death, because the treatment is not felt to be effective, or because they do not perceive that they need treatment," study author Anthony Morrison, from the University of Manchester, said in a journal news release. ... Read more

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Imaging Provides New Insights Into Schizophrenia

Posted 19 Sep 2013 by Drugs.com

THURSDAY, Sept. 19 – A new imaging study reveals abnormalities in the white matter of brains of people with schizophrenia. Researchers used two types of brain imaging: magnetic resonance spectroscopy, which measures the levels of particular chemicals in the brain; and magnetization transfer imaging, which detects changes in the level of myelin in the brain's white matter. Nerve cells must be insulated by myelin to effectively transmit signals from one part of the brain to the other, explained the authors of the study published Sept. 15 in the journal Biological Psychiatry. "The notion that the brain in schizophrenia is characterized by abnormalities in connections between distant brain regions is not new, and imaging studies using diffusion tensor imaging have long suggested that the white matter where these connections travel is abnormal in this condition," study senior author Dr. ... Read more

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FDA Medwatch Alert: Zyprexa Relprevv (Olanzapine Pamoate): Drug Safety Communication - FDA Investigating Two Deaths Following Injection

Posted 18 Jun 2013 by Drugs.com

ISSUE: FDA is investigating two unexplained deaths in patients who received an intramuscular injection of the antipsychotic drug Zyprexa Relprevv (olanzapine pamoate).  The patients died 3-4 days after receiving an appropriate dose of the drug, well after the 3-hour post-injection monitoring period required under the Zyprexa Relprevv Risk Evaluation and Mitigation Strategy (REMS).  Both patients were found to have very high olanzapine blood levels after death. BACKGROUND: Under the REMS, patients are required to receive the Zyprexa Relprevv injection at a REMS-certified health care facility, to be continuously monitored at the facility for at least 3 hours following an injection, and to be accompanied home from the facility.  The Zyprexa Relprevv label contains warnings about the risk of post-injection delirium sedation syndrome (PDSS), a serious condition in which the drug enters the bl ... Read more

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FDA Approves Once-Monthly Abilify Maintena (aripiprazole) for Extended-Release Injectable Suspension for the Treatment of Schizophrenia

Posted 1 Mar 2013 by Drugs.com

TOKYO & COPENHAGEN, Denmark--(BUSINESS WIRE)--Feb 28, 2013 - Otsuka Pharmaceutical Co., Ltd. (Otsuka) and H. Lundbeck A/S (Lundbeck) announced the U.S. Food and Drug Administration (FDA) has approved Abilify Maintena (aripiprazole) for extended- release injectable suspension, an intramuscular (IM) depot formulation indicated for the treatment of schizophrenia. Abilify Maintena is the first dopamine D2 partial agonist approved as a once- monthly injection. It contributes a new treatment option to address the ongoing need for relapse prevention in patients with schizophrenia – a chronic, debilitating disease. Efficacy was demonstrated in a 52-week, placebo-controlled, double-blind, randomized-withdrawal, Phase 3 maintenance trial of Abilify Maintena in patients with schizophrenia. The time to relapse was the primary endpoint. In the trial, Abilify Maintena (n=269 adult patients) s ... Read more

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Psychiatric Drugs More Often Prescribed in the South

Posted 1 Feb 2013 by Drugs.com

FRIDAY, Feb. 1 – Use of psychiatric medications is most prevalent in the southern United States and least prevalent in the West, according to a new U.S. study. Although people living in the West are the least likely to use antipsychotics, antidepressants and stimulants, the Yale researchers found that the drugs' use is 40 percent higher in a large section of the South than in other parts of the country. The study authors attributed this discrepancy to variations in local access to health care and marketing efforts within the pharmaceutical industry. "The geographic patterns we identify are striking and map onto the patterns found for a host of other medical conditions and treatments, from cognitive decline to bypass surgery," Marissa King, assistant professor of organizational behavior at the Yale School of Management, said in a school news release. "Our work suggests that access to ... Read more

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FDA Approves Adasuve (loxapine) Inhalation Powder for the Acute Treatment of Agitation Associated with Schizophrenia or Bipolar I Disorder in Adults

Posted 21 Dec 2012 by Drugs.com

MOUNTAIN VIEW, Calif., Dec. 21, 2012 /PRNewswire/ -- Alexza Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) approved Adasuve (loxapine) Inhalation Powder 10 mg for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults.  Adasuve combines Alexza's proprietary Staccato® delivery system with the antipsychotic drug, loxapine.  The Staccato system is a hand-held inhaler that delivers a drug aerosol to the deep lung that results in rapid systemic delivery and absorption of a drug.  See below for Important Safety Information about Adasuve, including Boxed Warnings. "The approval of Adasuve is an important event in the treatment of agitation.  Adasuve is the first approved non-injectable therapy for the acute treatment of agitation in adults with schizophrenia and bipolar I disorder.  As noted in the consensus guidel ... Read more

Related support groups: Bipolar Disorder, Schizophrenia, Agitation, Antipsychotic, Bipolar, Loxapine, Bipolar I Disorder

Long-Term Use of Some Antipsychotics Not Warranted in Older Adults: Study

Posted 28 Nov 2012 by Drugs.com

WEDNESDAY, Nov. 28 – The safety and effectiveness of four drugs commonly used to treat older adults with schizophrenia, dementia, bipolar disorder and other mental health conditions are being called into question by a new study. The drugs – aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel) and risperidone (Risperdal) – are among medications called atypical antipsychotics and are approved by the U.S. Food and Drug Administration to treat schizophrenia and bipolar disorders. But physicians often pen off-label prescriptions for people with dementia, post-traumatic stress disorder (PTSD) and other mood disorders to help alleviate symptoms of psychosis as well as anxiety, agitation and aggression. The medications have been in use since the early 1990s. The new study, published in the Nov. 27 issue of the Journal of Clinical Psychiatry, involved 332 patients older than 40 ... Read more

Related support groups: Bipolar Disorder, Seroquel, Abilify, Post Traumatic Stress Disorder, Schizophrenia, Zyprexa, Risperdal, Geodon, Risperidone, Saphris, Dementia, Seroquel XR, Latuda, Alzheimer's Disease, Quetiapine, Olanzapine, Invega, Clozapine, Clozaril, Aripiprazole

Schizophrenia Patients Who Take Antipsychotics Live Longer, Study Says

Posted 14 Nov 2012 by Drugs.com

WEDNESDAY, Nov. 14 – People with schizophrenia are likely to live longer if they take their antipsychotic drugs on schedule, avoid extremely high doses and have regular visits with a mental-health professional, according to a new study. It's long been known that adhering to a drug regimen reduces the number of the delusions and hallucinations experienced by schizophrenia patients, but there have been concerns that known physical side effects of the medications – such as diabetes and heart disease – might increase the risk of death. In this study, researchers analyzed data collected from 1994 to 2004 on more than 2,100 adult schizophrenia patients in Maryland. The most common cause of death was cardiovascular disease, which was responsible for 28 percent of patient deaths. Unintended harm, in which researchers included suicide, caused 8 percent of patient deaths during the study ... Read more

Related support groups: Seroquel, Abilify, Schizophrenia, Zyprexa, Risperdal, Geodon, Risperidone, Saphris, Seroquel XR, Latuda, Quetiapine, Olanzapine, Invega, Clozapine, Clozaril, Aripiprazole, Fanapt, Ziprasidone, Zyprexa Zydis, Asenapine

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