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Schizophrenia Blog

Related terms: Catatonic Schizophrenia, Disorganized Schizophrenia, Paranoid Schizophrenia, Residual Schizophrenia, Schizophrenia, catatonic, Schizophrenia, disorganized, Schizophrenia, paranoid, Schizophrenia, residual, Schizophrenia, undifferentiated, Undifferentiated Schizophrenia

Newly Discovered Gene May Shed Light on Certain Brain Disorders

Posted 12 Feb 2014 by Drugs.com

WEDNESDAY, Feb. 12, 2014 – Scientists who discovered a gene that links the thickness of the brain's gray matter to intelligence say their finding might help improve understanding of brain disorders such as autism and schizophrenia. The team looked at the cerebral cortex, which is the outside layer of the human brain. It plays an important role in areas such as memory, attention, thought, language and consciousness. Previous research has shown that the thickness of the cerebral cortex is closely linked with intelligence. Until now, no genes associated with the thickness of the cerebral cortex have been identified, the study authors said. The researchers at King's College London, in England, analyzed DNA samples and MRI brain scans from nearly 1,600 healthy 14-year-olds, who also underwent tests to determine their intelligence levels. The scientists examined more than 54,000 variations ... Read more

Related support groups: Schizophrenia, Autism

Schizophrenia Linked to Pregnancy Complications, Study Suggests

Posted 6 Feb 2014 by Drugs.com

THURSDAY, Feb. 6, 2014 – Women with schizophrenia are at increased risk for serious problems during pregnancy and childbirth, according to a new study. Canadian researchers analyzed data on births in the province of Ontario from 2002 to 2011 and found that preeclampsia, preterm birth and other serious pregnancy and delivery complications were twice as likely to occur in women with schizophrenia than in those without the mental health disorder. Women with schizophrenia were more likely to develop placental abruption (in which placenta separates from the uterus) and septic shock, to undergo induced labor and cesarean section, to be transferred to an intensive care unit, and to be readmitted to the hospital after discharge. "Traditionally, women with schizophrenia have had low fertility rates, and little attention was paid to their reproductive health," study author Dr. Simon Vigod, a ... Read more

Related support groups: Schizophrenia

Psychotherapy May Be Effective Alternate Treatment for Schizophrenia, Study Finds

Posted 6 Feb 2014 by Drugs.com

THURSDAY, Feb. 6, 2014 – A form of psychotherapy known as cognitive behavioral therapy may be an effective option for schizophrenia patients who are unable or unwilling to take antipsychotic drugs, a new study suggests. Reporting Feb. 6 in The Lancet, British researchers say that the treatment can help ease patients' psychotic symptoms and boost their personal and social functioning. They note that many people with schizophrenia cannot take standard medications. "As many as half of all people with schizophrenia choose not to take drugs because of side effects that can include serious weight gain, development of metabolic disorders and an increased risk of sudden cardiac death, because the treatment is not felt to be effective, or because they do not perceive that they need treatment," study author Anthony Morrison, from the University of Manchester, said in a journal news release. ... Read more

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Imaging Provides New Insights Into Schizophrenia

Posted 19 Sep 2013 by Drugs.com

THURSDAY, Sept. 19 – A new imaging study reveals abnormalities in the white matter of brains of people with schizophrenia. Researchers used two types of brain imaging: magnetic resonance spectroscopy, which measures the levels of particular chemicals in the brain; and magnetization transfer imaging, which detects changes in the level of myelin in the brain's white matter. Nerve cells must be insulated by myelin to effectively transmit signals from one part of the brain to the other, explained the authors of the study published Sept. 15 in the journal Biological Psychiatry. "The notion that the brain in schizophrenia is characterized by abnormalities in connections between distant brain regions is not new, and imaging studies using diffusion tensor imaging have long suggested that the white matter where these connections travel is abnormal in this condition," study senior author Dr. ... Read more

Related support groups: Schizophrenia

FDA Medwatch Alert: Zyprexa Relprevv (Olanzapine Pamoate): Drug Safety Communication - FDA Investigating Two Deaths Following Injection

Posted 18 Jun 2013 by Drugs.com

ISSUE: FDA is investigating two unexplained deaths in patients who received an intramuscular injection of the antipsychotic drug Zyprexa Relprevv (olanzapine pamoate).  The patients died 3-4 days after receiving an appropriate dose of the drug, well after the 3-hour post-injection monitoring period required under the Zyprexa Relprevv Risk Evaluation and Mitigation Strategy (REMS).  Both patients were found to have very high olanzapine blood levels after death. BACKGROUND: Under the REMS, patients are required to receive the Zyprexa Relprevv injection at a REMS-certified health care facility, to be continuously monitored at the facility for at least 3 hours following an injection, and to be accompanied home from the facility.  The Zyprexa Relprevv label contains warnings about the risk of post-injection delirium sedation syndrome (PDSS), a serious condition in which the drug enters the bl ... Read more

Related support groups: Schizophrenia, Zyprexa, Olanzapine, Zyprexa Zydis, Zyprexa Intramuscular

FDA Approves Once-Monthly Abilify Maintena (aripiprazole) for Extended-Release Injectable Suspension for the Treatment of Schizophrenia

Posted 1 Mar 2013 by Drugs.com

TOKYO & COPENHAGEN, Denmark--(BUSINESS WIRE)--Feb 28, 2013 - Otsuka Pharmaceutical Co., Ltd. (Otsuka) and H. Lundbeck A/S (Lundbeck) announced the U.S. Food and Drug Administration (FDA) has approved Abilify Maintena (aripiprazole) for extended- release injectable suspension, an intramuscular (IM) depot formulation indicated for the treatment of schizophrenia. Abilify Maintena is the first dopamine D2 partial agonist approved as a once- monthly injection. It contributes a new treatment option to address the ongoing need for relapse prevention in patients with schizophrenia – a chronic, debilitating disease. Efficacy was demonstrated in a 52-week, placebo-controlled, double-blind, randomized-withdrawal, Phase 3 maintenance trial of Abilify Maintena in patients with schizophrenia. The time to relapse was the primary endpoint. In the trial, Abilify Maintena (n=269 adult patients) s ... Read more

Related support groups: Abilify, Schizophrenia, Aripiprazole, Abilify Discmelt

Psychiatric Drugs More Often Prescribed in the South

Posted 1 Feb 2013 by Drugs.com

FRIDAY, Feb. 1 – Use of psychiatric medications is most prevalent in the southern United States and least prevalent in the West, according to a new U.S. study. Although people living in the West are the least likely to use antipsychotics, antidepressants and stimulants, the Yale researchers found that the drugs' use is 40 percent higher in a large section of the South than in other parts of the country. The study authors attributed this discrepancy to variations in local access to health care and marketing efforts within the pharmaceutical industry. "The geographic patterns we identify are striking and map onto the patterns found for a host of other medical conditions and treatments, from cognitive decline to bypass surgery," Marissa King, assistant professor of organizational behavior at the Yale School of Management, said in a school news release. "Our work suggests that access to ... Read more

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FDA Approves Adasuve (loxapine) Inhalation Powder for the Acute Treatment of Agitation Associated with Schizophrenia or Bipolar I Disorder in Adults

Posted 21 Dec 2012 by Drugs.com

MOUNTAIN VIEW, Calif., Dec. 21, 2012 /PRNewswire/ -- Alexza Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) approved Adasuve (loxapine) Inhalation Powder 10 mg for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults.  Adasuve combines Alexza's proprietary Staccato® delivery system with the antipsychotic drug, loxapine.  The Staccato system is a hand-held inhaler that delivers a drug aerosol to the deep lung that results in rapid systemic delivery and absorption of a drug.  See below for Important Safety Information about Adasuve, including Boxed Warnings. "The approval of Adasuve is an important event in the treatment of agitation.  Adasuve is the first approved non-injectable therapy for the acute treatment of agitation in adults with schizophrenia and bipolar I disorder.  As noted in the consensus guidel ... Read more

Related support groups: Bipolar Disorder, Schizophrenia, Agitation, Antipsychotic, Bipolar, Loxapine, Bipolar I Disorder

Long-Term Use of Some Antipsychotics Not Warranted in Older Adults: Study

Posted 28 Nov 2012 by Drugs.com

WEDNESDAY, Nov. 28 – The safety and effectiveness of four drugs commonly used to treat older adults with schizophrenia, dementia, bipolar disorder and other mental health conditions are being called into question by a new study. The drugs – aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel) and risperidone (Risperdal) – are among medications called atypical antipsychotics and are approved by the U.S. Food and Drug Administration to treat schizophrenia and bipolar disorders. But physicians often pen off-label prescriptions for people with dementia, post-traumatic stress disorder (PTSD) and other mood disorders to help alleviate symptoms of psychosis as well as anxiety, agitation and aggression. The medications have been in use since the early 1990s. The new study, published in the Nov. 27 issue of the Journal of Clinical Psychiatry, involved 332 patients older than 40 ... Read more

Related support groups: Bipolar Disorder, Seroquel, Post Traumatic Stress Disorder, Abilify, Schizophrenia, Zyprexa, Risperdal, Geodon, Saphris, Risperidone, Dementia, Seroquel XR, Latuda, Alzheimer's Disease, Quetiapine, Olanzapine, Invega, Clozapine, Clozaril, Aripiprazole

Schizophrenia Patients Who Take Antipsychotics Live Longer, Study Says

Posted 14 Nov 2012 by Drugs.com

WEDNESDAY, Nov. 14 – People with schizophrenia are likely to live longer if they take their antipsychotic drugs on schedule, avoid extremely high doses and have regular visits with a mental-health professional, according to a new study. It's long been known that adhering to a drug regimen reduces the number of the delusions and hallucinations experienced by schizophrenia patients, but there have been concerns that known physical side effects of the medications – such as diabetes and heart disease – might increase the risk of death. In this study, researchers analyzed data collected from 1994 to 2004 on more than 2,100 adult schizophrenia patients in Maryland. The most common cause of death was cardiovascular disease, which was responsible for 28 percent of patient deaths. Unintended harm, in which researchers included suicide, caused 8 percent of patient deaths during the study ... Read more

Related support groups: Seroquel, Abilify, Schizophrenia, Zyprexa, Risperdal, Geodon, Saphris, Risperidone, Seroquel XR, Latuda, Quetiapine, Olanzapine, Invega, Clozapine, Clozaril, Aripiprazole, Fanapt, Ziprasidone, Zyprexa Zydis, Asenapine

New Gene Mutations Tied to Schizophrenia

Posted 8 Oct 2012 by Drugs.com

MONDAY, Oct. 8 – Dozens of newly discovered genetic mutations that play a significant role in the development of schizophrenia add to the list of genetic variants linked to the disease, new research suggests. Schizophrenia typically appears in people during their teens or early adulthood, but many of these newly identified mutations are most active during fetal development, according to researchers from Columbia University Medical Center in New York City. They said their findings show that both the function of the mutated gene and the timing of when the gene is expressed seems to have a major effect on the risk of developing schizophrenia. The genetic errors pinpointed in this study are spontaneous, or "de novo" mutations, which means they are present in patients but not in their parents. This supports studies showing that environmental factors, such as malnutrition or infections ... Read more

Related support groups: Schizophrenia

More U.S. Kids Prescribed Off-Label Antipsychotics: Study

Posted 18 Sep 2012 by Drugs.com

TUESDAY, Sept. 18 – Over the past decade, off-label use of antipsychotic drugs has increased among children enrolled in Medicaid, according to a new study representing 35 percent of children in the United States. Off-label drug use is a term used to describe when drugs are prescribed using a dosage, type of dosage or for a purpose that hasn't yet been approved by the U.S. Food and Drug Administration. In the study, researchers from the Children's Hospital of Philadelphia found a 62 percent jump in the number of publicly insured children between the ages of 3 and 18 taking antipsychotics. In 2007 alone, 65 percent of the 354,000 children on these drugs were taking them for uses that have not been approved by the FDA, the investigators pointed out. "We knew that the number of children prescribed antipsychotics had grown steadily over the past two decades, particularly among children with ... Read more

Related support groups: Bipolar Disorder, Attention Deficit Hyperactivity Disorder (ADHD), Seroquel, Abilify, Schizophrenia, Zyprexa, Risperdal, Geodon, Saphris, Risperidone, Seroquel XR, Latuda, Quetiapine, Autism, Olanzapine, Invega, Clozapine, Clozaril, Aripiprazole, Fanapt

Older Dads May Raise Risk for Autism, Schizophrenia in Kids

Posted 22 Aug 2012 by Drugs.com

WEDNESDAY, Aug. 22 – Men who have kids later in life may pass on more new genetic mutations to their offspring, possibly raising their child's risk of disorders such as autism and schizophrenia, new research suggests. New mutations arise in the sperm cells of men near the time of conception instead of being passed down through generations. They have been associated with relatively rare cases of non-hereditary autism. Researchers in Iceland searched the genomes of 78 families for new mutations as they first appeared and looked at how the number of these mutations in children was related to the age of their parents. In most of the families, the child had either non-hereditary autism or schizophrenia. The study, which was published Aug. 22 in the journal Nature, found that every year a man ages, he is predicted to pass on more than two additional new (or "de novo") mutations. More than 97 ... Read more

Related support groups: Schizophrenia, Autism

More Kids Taking Antipsychotics for ADHD: Study

Posted 7 Aug 2012 by Drugs.com

TUESDAY, Aug. 7 – Use of powerful antipsychotic medications such as Abilify and Risperdal to control youngsters with attention-deficit/hyperactivity disorder (ADHD) and other behavior problems has skyrocketed in recent years, a new study finds. Antipsychotics are approved to treat bipolar disorder, schizophrenia, other serious mental problems and irritability related to autism. But they don't have U.S. Food and Drug Administration approval for ADHD or other childhood behavior problems, and their use for this purpose is considered "off label." "Only a small proportion of antipsychotic treatment of children (6 percent) and adolescents (13 percent) is for FDA-approved clinical indications," said lead researcher Dr. Mark Olfson, a professor of clinical psychiatry at Columbia University Medical Center in New York City. "These national trends focus attention on the substantial and growing ... Read more

Related support groups: Bipolar Disorder, Attention Deficit Hyperactivity Disorder (ADHD), Seroquel, Abilify, Schizophrenia, Zyprexa, Risperdal, Geodon, Saphris, Risperidone, Seroquel XR, Latuda, Quetiapine, Olanzapine, Invega, Clozapine, Clozaril, Aripiprazole, Fanapt, Ziprasidone

More Drug Trials Needed for Conditions Affecting Kids: Review

Posted 25 Jul 2012 by Drugs.com

WEDNESDAY, July 25 – A new review finds that while children account for almost 60 percent of those with five common medical conditions, only 12 percent of clinical trials of drugs for those conditions examined their effects on pediatric patients. Yet, the review authors noted, previous research has shown that off-label drugs, where the medicine has only been approved for adult use by the U.S. Food and Drug Administration, make up as much as 79 percent of the medications given to children in hospitals and up to 56 percent of drugs prescribed for kids in doctors' offices. "We think this contrast is striking, and speaks to the under-representation of research on kids," said review author Dr. Florence Bourgeois, an assistant professor of pediatrics at Boston Children's Hospital and Harvard Medical School in Boston. "Understandably, whenever we see an adverse event the concern is, 'Could ... Read more

Related support groups: Depression, Bipolar Disorder, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Asthma, Schizophrenia

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