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Antipsychotics Linked to Lower Brain Volume in Schizophrenia Patients

Posted 9 days ago by Drugs.com

FRIDAY, July 18, 2014 – Antipsychotic drugs are associated with a slight decrease in both brain cells and connections between brain cells in schizophrenia patients, a new study indicates. However, this loss of what is called brain volume does not worsen schizophrenia symptoms or affect overall mental function, researchers reported in the study published online July 18 in the journal PLoS One. "It's important to stress that the loss of brain volume doesn't appear to have any effect on people over the nine-year follow-up we conducted, and patients should not stop their medication on the basis of this research," study author Dr. Graham Murray, of the Behavioral and Clinical Neuroscience Institute and the department of psychiatry at the University of Cambridge in England, said in a university news release. "A key question in future will be to examine whether there is any effect of this ... Read more

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Taking Antipsychotic Drugs While Pregnant May Harm Newborns: Study

Posted 4 Jun 2014 by Drugs.com

WEDNESDAY, June 4, 2014 – Although antipsychotic medications have not been shown to cause birth defects, new research suggests these drugs can have other harmful effects on babies. Antipsychotic drugs are used to treat a range of mental illnesses, such as schizophrenia, depression and bipolar disorder. An Australian study found that babies born to women on these medications are more likely to spend time in a neonatal intensive care unit (NICU) or to need specialized care after birth. The researchers cautioned that health guidelines for the use of antipsychotic drugs during pregnancy should be clarified. "There's been little research on antipsychotic medication during pregnancy, and if it affects babies. The lack of data has made it very difficult for clinicians to say anything conclusively on how safe it is for babies," lead investigator, Jayashri Kulkarni, director of the Monash ... Read more

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Antipsychotics Help Cut Crime Rate: Study

Posted 9 May 2014 by Drugs.com

FRIDAY, May 9, 2014 – People with psychiatric disorders are less likely to commit violent crimes if they are taking antipsychotic or mood-stabilizing drugs, a new study suggests. Researchers analyzed data from more than 80,000 men and women in Sweden who were prescribed antipsychotic or mood-stabilizing drugs. Over three years, 6.5 percent of the men and 1.4 percent of the women were convicted of a violent crime. Compared to when they were not on medication, violent crime fell by 45 percent among those who took antipsychotics and by 24 percent among those who took mood stabilizers, according to the research, which was published online May 8 in The Lancet. The two types of medications are often used together, but there was no evidence that prescribing both medications at once led to any greater reduction in violent crime, the researchers said. They also noted that mood stabilizers were ... Read more

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Too Many Foster Kids With ADHD Treated With Antipsychotic Drugs: Study

Posted 13 Apr 2014 by Drugs.com

THURSDAY, April 10, 2014 – Antipsychotic drugs are increasingly being prescribed to treat attention-deficit/hyperactivity disorder (ADHD) in children and teens in foster care, according to a new study. The use of these drugs to treat ADHD has not been approved by the U.S. Food and Drug Administration, and is known as an "atypical" use, the researchers explained. But their study found that antipsychotics were used to treat nearly one-third of foster care youth aged 2 to 17 who had been diagnosed with ADHD. The most common types of antipsychotics used were risperidone, aripiprazole and quetiapine. The study looked at administrative data on more than 260,000 youths aged 2 to 17, enrolled in one state's Medicaid program in 2006, to determine the average number of days of atypical antipsychotic use in kids. Researchers also looked specifically at a subgroup of kids with ADHD who were not ... Read more

Related support groups: Attention Deficit Hyperactivity Disorder (ADHD), Seroquel, Abilify, Zyprexa, Risperdal, Geodon, Risperidone, Saphris, Seroquel XR, Latuda, Quetiapine, Olanzapine, Invega, Clozapine, Clozaril, Aripiprazole, Fanapt, Ziprasidone, Zyprexa Zydis, Asenapine

FDA: Janssen Pharmaceuticals, Inc. to plead guilty and pay over $1.6 billion to resolve allegations of misbranding and filing false claims for its schizophrenia drug Risperdal

Posted 4 Nov 2013 by Drugs.com

November 4, 2013 – On behalf of the U.S. Food and Drug Administration, the U.S. Department of Justice today announced a guilty plea agreement with Janssen Pharmaceuticals, Inc., (JPI) of Titusville, N.J., and a $400 million criminal fine for introducing a misbranded drug, Risperdal (risperidone), into interstate commerce. A Johnson & Johnson Company, JPI must also pay $1.25 billion under a separate civil settlement concerning the same drug. The combined criminal plea and civil settlement agreement related to Risperdal totals more than $1.67 billion. Additional charges related to JPI’s healthcare fraud and other Federal agencies can be found at http://www.justice.gov/opa/pr/2013/November/13-ag-1170.html. The U.S. District Court for the Eastern District of Pennsylvania oversaw the agreement. “When pharmaceutical companies ignore the FDA’s requirements, they not only risk endangering t ... Read more

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APA Issues List of Common Antipsychotic Uses to Question

Posted 24 Sep 2013 by Drugs.com

ARLINGTON, Va. (September 20, 2013) — The American Psychiatric Association today released a list of specific uses of antipsychotic medications that are common, but potentially unnecessary and sometimes harmful, as part of the Choosing Wisely® campaign, an initiative of the ABIM Foundation. The list identifies five targeted, evidence-based recommendations that can prompt conversations between patients and physicians about what care is really necessary. APA’s list includes the following five recommendations: Don’t prescribe antipsychotic medications to patients for any indication without appropriate initial evaluation and appropriate ongoing monitoring Don’t routinely prescribe two or more antipsychotic medications concurrently Don’t use antipsychotics as first choice to treat behavioral and psychological symptoms of dementia Don’t routinely prescribe antipsychotic medications as a first-l ... Read more

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'Exposure Therapy' Along With Antidepressants May Help With OCD

Posted 11 Sep 2013 by Drugs.com

WEDNESDAY, Sept. 11 – New research suggests that patients with obsessive-compulsive disorder do better when they combine intensive "exposure therapy" with an antidepressant rather than taking a common two-drug combination. There are caveats, however: The kind of exposure therapy used in the study required patients to see therapists twice a week, which can be expensive; some obsessive-compulsive disorder (OCD) patients simply refuse to engage in this kind of therapy; and it's not clear what happens to patients in the long term. Still, OCD patients who take antidepressants and still have symptoms should try exposure therapy before taking the medications with a drug known as risperidone, said study lead author Dr. Helen Blair Simpson, a professor of clinical psychiatry at Columbia University. "If risperidone is tried, clinicians should know that it is likely to help only a small subset, ... Read more

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U.S. Nursing Homes Reducing Use of Antipsychotic Drugs

Posted 27 Aug 2013 by Drugs.com

TUESDAY, Aug. 27 – A year-old nationwide effort to prevent the unnecessary use of antipsychotic medications in U.S. nursing homes already seems to be working, public health officials report, as facilities begin to opt for patient-centered approaches over drugs to treat dementia and other related complications. So far, the program has seen more than a 9 percent drop in the national use of antipsychotics among long-term nursing-home residents, when comparing the period of January to March 2013 with October to December 2011. The National Partnership to Improve Dementia Care was launched in 2012 by the U.S. Centers for Medicare & Medicaid Services (CMS). At issue: the broad over-prescription of antipsychotics among the nation's roughly 1.5 million nursing-home residents. "This important partnership to improve dementia care in nursing homes is yielding results," Dr. Patrick Conway, CMS ... Read more

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Antipsychotic Drugs May Triple Kids' Diabetes Risk, Study Suggests

Posted 21 Aug 2013 by Drugs.com

WEDNESDAY, Aug. 21 – Antipsychotic medications such as Seroquel, Abilify and Risperdal can triple a child's risk of developing type 2 diabetes within the first year of usage, according to a new study. Powerful antipsychotics traditionally were used to treat schizophrenia. Now the majority of prescriptions for antipsychotic medications are for treatment of bipolar disorder, ADHD and mood disorders such as depression, according to prior research. But antipsychotic drugs make a child much more likely to develop type 2 diabetes than the medications typically prescribed for these other psychiatric conditions, said corresponding author Wayne Ray, director of the division of pharmacoepidemiology at the Vanderbilt University School of Medicine, in Nashville, Tenn. "We found that children who received antipsychotic medications were three times as likely to develop type 2 diabetes," Ray said. ... Read more

Related support groups: Depression, Bipolar Disorder, Attention Deficit Hyperactivity Disorder (ADHD), Diabetes, Type 2, Seroquel, Abilify, Zyprexa, Risperdal, Geodon, Risperidone, Saphris, Seroquel XR, Latuda, Quetiapine, Olanzapine, Invega, Clozapine, Clozaril, Aripiprazole, Fanapt

Bipolar Disorder Drugs May 'Tweak' Genes Affecting Brain

Posted 25 Apr 2013 by Drugs.com

THURSDAY, April 25 – Medications taken by people with bipolar disorder may actually be nudging hundreds of genes that direct the brain to behave more normally, according to new research. The study suggests that antipsychotic drugs activate a wide range of genes, changing their function, said lead author Dr. Melvin McInnis. "A gene's activity in any given cell will vary depending on what it's exposed to," said McInnis, a professor of bipolar disorder and depression at the School of Medicine at the University of Michigan. It's not often that scientists stumble upon something in research that they totally weren't expecting to see. "It was a major surprise to us that people treated with an antipsychotic [medication] had changes in the gene expression pattern," McInnis said. The findings could help point the way to new gene-targeted and stem cell therapies, and provide valuable insight into ... Read more

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Antipsychotic Drug Use Rising for Kids on Medicaid, Study Finds

Posted 23 Mar 2013 by Drugs.com

FRIDAY, March 22 – Use of antipsychotic drugs among Medicaid-insured children increased sharply from 1997 to 2006, according to a new study. These drugs were prescribed for children covered by Medicaid five times more often than for children with private insurance. Researchers said this disparity should be examined more closely, particularly because these drugs were often prescribed for a so-called off-label use, which is when a drug is used in a different way than has been approved by the U.S. Food and Drug Administration. "Many [of the children] were diagnosed with behavioral rather than psychotic conditions for which [these drugs] have FDA-approved labeling," study author Julie Zito, a professor in the University of Maryland School of Pharmacy, said in a university news release. "These are often children with serious socioeconomic and family life problems," she noted. "We need more ... Read more

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Antipsychotic Meds Not That Helpful for Depression: Study

Posted 13 Mar 2013 by Drugs.com

TUESDAY, March 12 – For people who don't fully respond to antidepressants, adding commonly prescribed antipsychotic drugs appears to be only slightly effective and is linked to unwelcome side effects, a new study finds. Drugs added to antidepressants (like Prozac, Paxil and Celexa) include the antipsychotic medications aripiprazole (Abilify), quetiapine (Seroquel), risperidone (Risperdal) and olanzapine/fluoxetine (Symbyax). Antipsychotic drugs are traditionally used to treat conditions such as schizophrenia, bipolar disorder and obsessive-compulsive disorder – not depression. "The evidence supporting the use of antipsychotics in depression is marginal," said lead researcher Glen Spielmans, an associate professor in the department of psychology at Metropolitan State University in St. Paul, Minn. Antipsychotic treatment of depression has become increasingly widespread but the ... Read more

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Psychiatric Drugs More Often Prescribed in the South

Posted 1 Feb 2013 by Drugs.com

FRIDAY, Feb. 1 – Use of psychiatric medications is most prevalent in the southern United States and least prevalent in the West, according to a new U.S. study. Although people living in the West are the least likely to use antipsychotics, antidepressants and stimulants, the Yale researchers found that the drugs' use is 40 percent higher in a large section of the South than in other parts of the country. The study authors attributed this discrepancy to variations in local access to health care and marketing efforts within the pharmaceutical industry. "The geographic patterns we identify are striking and map onto the patterns found for a host of other medical conditions and treatments, from cognitive decline to bypass surgery," Marissa King, assistant professor of organizational behavior at the Yale School of Management, said in a school news release. "Our work suggests that access to ... Read more

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Long-Term Use of Some Antipsychotics Not Warranted in Older Adults: Study

Posted 28 Nov 2012 by Drugs.com

WEDNESDAY, Nov. 28 – The safety and effectiveness of four drugs commonly used to treat older adults with schizophrenia, dementia, bipolar disorder and other mental health conditions are being called into question by a new study. The drugs – aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel) and risperidone (Risperdal) – are among medications called atypical antipsychotics and are approved by the U.S. Food and Drug Administration to treat schizophrenia and bipolar disorders. But physicians often pen off-label prescriptions for people with dementia, post-traumatic stress disorder (PTSD) and other mood disorders to help alleviate symptoms of psychosis as well as anxiety, agitation and aggression. The medications have been in use since the early 1990s. The new study, published in the Nov. 27 issue of the Journal of Clinical Psychiatry, involved 332 patients older than 40 ... Read more

Related support groups: Bipolar Disorder, Seroquel, Abilify, Post Traumatic Stress Disorder, Schizophrenia, Zyprexa, Risperdal, Geodon, Risperidone, Saphris, Dementia, Seroquel XR, Latuda, Alzheimer's Disease, Quetiapine, Olanzapine, Invega, Clozapine, Clozaril, Aripiprazole

Schizophrenia Patients Who Take Antipsychotics Live Longer, Study Says

Posted 14 Nov 2012 by Drugs.com

WEDNESDAY, Nov. 14 – People with schizophrenia are likely to live longer if they take their antipsychotic drugs on schedule, avoid extremely high doses and have regular visits with a mental-health professional, according to a new study. It's long been known that adhering to a drug regimen reduces the number of the delusions and hallucinations experienced by schizophrenia patients, but there have been concerns that known physical side effects of the medications – such as diabetes and heart disease – might increase the risk of death. In this study, researchers analyzed data collected from 1994 to 2004 on more than 2,100 adult schizophrenia patients in Maryland. The most common cause of death was cardiovascular disease, which was responsible for 28 percent of patient deaths. Unintended harm, in which researchers included suicide, caused 8 percent of patient deaths during the study ... Read more

Related support groups: Seroquel, Abilify, Schizophrenia, Zyprexa, Risperdal, Geodon, Risperidone, Saphris, Seroquel XR, Latuda, Quetiapine, Olanzapine, Invega, Clozapine, Clozaril, Aripiprazole, Fanapt, Ziprasidone, Zyprexa Zydis, Asenapine

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