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1 in 4 Hospitalized Newborns Gets Heartburn Drugs, Despite Risks

Posted 1 day 13 hours ago by Drugs.com

WEDNESDAY, April 27, 2016 – Despite reported risks, nearly one in four infants in neonatal intensive care units (NICUs) are given stomach acid-suppressing drugs, researchers report. However, they noted that the use of these medications has started to decline some in recent years. A number of studies have linked the use of stomach acid-suppressing drugs in hospitalized high-risk infants with infections, necrotizing enterocolitis (a serious disease where intestinal tissue begins to die off) and increased risk of death, the researchers said. These drugs include histamine-2 receptor antagonists such as ranitidine (Zantac), and proton pump inhibitors such as esomeprazole (Nexium). Researchers at Nationwide Children's Hospital in Columbus, Ohio, analyzed data from 43 children's hospitals across the United States from 2006 to 2013. They found that nearly 24 percent of roughly 122,000 newborns ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Dexilant, Prevacid, Lansoprazole, Pepcid, Delivery, Aciphex, Famotidine, Heartburn Relief, Zegerid, Vimovo, Zantac 150, Rabeprazole, Esomeprazole

Common Heartburn Drugs Linked to Kidney Disease in Study

Posted 14 days ago by Drugs.com

THURSDAY, April 14, 2016 – People who use certain drugs for chronic heartburn may be at increased risk of developing kidney disease, a new study suggests. The research is the latest to highlight potential risks from drugs called proton pump inhibitors (PPIs). PPIs include prescription and over-the-counter drugs, such as Prilosec, Prevacid and Nexium. But prolonged use of PPIs has been linked to certain nutrient deficiencies and bone-density loss. According to the U.S. Food and Drug Administration, bone fractures are considered a safety concern when people use PPIs for a year or more. More recently, research has hinted at additional hazards. Last year, for example, a study tied the medications to a slight increase in heart attack risk. However, neither that study nor this new one prove that PPIs are directly to blame for these problems. "I cannot say for certain that this is ... Read more

Related support groups: GERD, Omeprazole, Prilosec, Renal Failure, Protonix, Pantoprazole, Barrett's Esophagus, Chronic Kidney Disease, Zegerid, Prilosec OTC, Zegerid OTC, Omeclamox-Pak, Omeprazole/Sodium Bicarbonate/Magnesium Hydroxide, Omeprazole/Sodium Bicarbonate, Protonix IV, Omesec, Amoxicillin/clarithromycin/omeprazole, Renal and Genitourinary Disorders

Doctors Often Overestimate Promise of Newly Approved Drugs

Posted 17 days ago by Drugs.com

TUESDAY, April 12, 2016 – Use of the word "breakthrough" in the U.S. Food and Drug Administration's expedited approval process could mislead doctors about the new drugs' actual benefits, researchers warn. The U.S. Congress in 2012 gave FDA the power to designate a drug as a "breakthrough therapy" if preliminary clinical evidence suggests an advantage over existing medications. But a survey of nearly 700 doctors revealed that many tended to misinterpret "breakthrough." Doctors often believed the drugs were supported by stronger evidence than the law requires to achieve that designation, said lead author Dr. Aaron Kesselheim. He is a faculty member at Brigham and Women's Hospital in Boston. "When people hear 'breakthrough,' it gives them an inappropriately elevated sense of what the drug might do," Kesselheim said. "It may give physicians false reassurance about the outcomes they might ... Read more

Related support groups: Nexium, Prilosec, Diagnosis and Investigation

Widely Used Heartburn Drugs Linked to Dementia Risk in Study

Posted 15 Feb 2016 by Drugs.com

MONDAY, Feb. 15, 2016 – A popular class of heartburn medications might raise a senior's risk of dementia, a new study suggests. Called proton pump inhibitors (PPIs), this group of drugs includes Prilosec, Nexium and Prevacid. They work by lowering the amount of acid produced by the stomach. But German researchers found that people 75 or older who regularly take the medications had a 44 percent increased risk of dementia, compared with seniors not using the drugs. The study only found an association, however, and not a cause-and-effect link. "To evaluate cause-and-effect relationships between long-term PPI use and possible effects on cognition in the elderly, randomized, prospective clinical trials are needed," said corresponding author Britta Haenisch, from the German Center for Neurodegenerative Diseases in Bonn. In the meantime, "Clinicians should follow guidelines for PPI ... Read more

Related support groups: GERD, Gas, Omeprazole, Nexium, Dementia, Prilosec, Indigestion, Protonix, Alzheimer's Disease, Pantoprazole, Stomach Ulcer, Dexilant, Prevacid, Lansoprazole, Gastric Ulcer, Aciphex, Peptic Ulcer, Prevpac, Duodenitis/Gastritis, Mild Cognitive Impairment

Could a Lung Cancer Drug Work Better With Coke?

Posted 13 Feb 2016 by Drugs.com

FRIDAY, Feb. 12, 2016 – Patients with the leading form of lung cancer may be able to look to Coca-Cola Classic to solve a common medicinal challenge, new research suggests. As the Dutch scientists explain it, the effectiveness of the powerful lung cancer drug Tarceva (erlotinib) depends on the pH level of the stomach. But many people on Tarceva must also take a proton pump inhibitor heartburn medication – such as Nexium or Prilosec – which raises stomach pH to more alkaline levels. That higher pH can lower the absorption rate for Tarceva, cutting its effectiveness in fighting non-small-cell lung cancer, research suggests. One prior study involving healthy volunteers found the use of Prilosec lowered blood concentrations of Tarceva by 61 percent. What to do? In the new study, researchers led by Dr. Roelof van Leeuwen, of Erasmus MC Cancer Institute in Rotterdam, the Netherlands, ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Non-Small Cell Lung Cancer, Tarceva, Tasigna, Sprycel, Esomeprazole, Prilosec OTC, Iressa, Dasatinib, Nilotinib, Erlotinib, Gefitinib, Protonix IV, Nexium IV, Omesec, Nexium 24HR

Heartburn Meds Linked to Chronic Kidney Disease

Posted 11 Jan 2016 by Drugs.com

MONDAY, Jan. 11, 2016 – A type of heartburn medication called proton pump inhibitors may be linked to long-term kidney damage, a new study suggests. Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach. People who use proton pump inhibitors (PPIs) have a 20 percent to 50 percent higher risk of chronic kidney disease compared with nonusers, said lead author Dr. Morgan Grams, an assistant professor of epidemiology at Johns Hopkins University in Baltimore. The study was published Jan. 11 in JAMA Internal Medicine. The study doesn't establish a direct cause-and-effect relationship between the drugs and chronic kidney disease. However, Grams said, "We found there was an increasing risk associated with an increasing dose. That suggests that perhaps this observed effect is real." Proton pump ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Renal Failure, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Chronic Kidney Disease, Aciphex, Rabeprazole, Zegerid, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Kapidex, Dexlansoprazole, Zegerid OTC

Chronic Heartburn Drugs Tied to Higher Risk of Kidney Disease

Posted 27 Oct 2015 by Drugs.com

TUESDAY, Oct. 27, 2015 – A common type of heartburn medication called proton pump inhibitors (PPIs) seem to be linked with increased risk of chronic kidney disease, two new studies suggest. Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach. While the current studies have shown an association between these drugs and the development of chronic kidney disease, they did not prove a cause-and-effect relationship. Still, the lead author of one of the studies believes, "It is very reasonable to assume that PPIs themselves can cause chronic kidney disease," said Dr. Pradeep Arora, a nephrologist and associate professor at the SUNY Buffalo School of Medicine and Biomedical Science in Buffalo, N.Y. "Patients should only use PPIs for [U.S. Food and Drug Administration]-approved indications, and ... Read more

Related support groups: High Blood Pressure, Diabetes, Type 2, GERD, Hypertension, Omeprazole, Nexium, Prilosec, Renal Failure, Indigestion, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Chronic Kidney Disease, Aciphex, Duodenitis/Gastritis, Rabeprazole, Esomeprazole, Zegerid

Popular Heartburn Meds Linked to Higher Risk of Heart Attack

Posted 10 Jun 2015 by Drugs.com

WEDNESDAY, June 10, 2015 – People who use certain heartburn drugs for a long period of time may have a slightly heightened risk of suffering a heart attack, a new study suggests. Using medical records from nearly 300,000 U.S. adults with acid reflux disease (commonly called heartburn), researchers found that the risk of heart attack was slightly elevated among those using proton pump inhibitors. Proton pump inhibitors are a group of acid-suppressing drugs that include brand-names such as Prevacid, Prilosec and Nexium. In 2009, they were the third most commonly used type of drug in the United States, the researchers said. The study, funded by the U.S. National Institutes of Health, does not prove the drugs cause heart attack. And experts were divided over what to make of the connection. Another class of heartburn drug – so-called H2-blockers – was not linked to any increase in heart ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Indigestion, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Duodenitis/Gastritis, Rabeprazole, Esomeprazole, Zegerid, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Erosive Gastritis

Antacids May Improve Head and Neck Cancer Survival

Posted 2 Dec 2014 by Drugs.com

TUESDAY, Dec. 2, 2014 – Using antacids to control acid reflux may improve head and neck cancer patients' chances of survival, a new study suggests. The researchers examined the effects that two types of antacids – proton pump inhibitors and histamine 2 blockers – had on head and neck cancer patients. More than two-thirds of the nearly 600 patients in the study took one or both types of the antacids after their cancer diagnosis. Acid reflux – commonly known as heartburn – is a common side effect of chemotherapy or radiation treatment, according to the researchers. Proton pump inhibitors include drugs such as Prilosec, Nexium and Prevacid, while histamine 2 blockers include drugs such as Tagamet, Zantac and Pepcid. Compared to patients who didn't take antacids, those who took proton pump inhibitors had a 45 percent lower risk of death, according to the researchers. They also found ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Dexilant, Prevacid, Pepcid, Lansoprazole, Aciphex, Famotidine, Heartburn Relief, Zantac 150, Rabeprazole, Esomeprazole, Zegerid, Pepcid AC, Pepcid Complete

Could Popular Heartburn Drugs Upset Your 'Good' Gut Bugs?

Posted 25 Nov 2014 by Drugs.com

TUESDAY, Nov. 25, 2014 – Heartburn drugs such as Prilosec and Nexium may disrupt the makeup of bacteria in the digestive system, potentially boosting the risk of infections and other problems, a small new study suggests. The research doesn't confirm that these changes make it more likely users will become ill, and study authors aren't recommending that anyone stop taking the so-called proton pump inhibitors. However, these antacids "should be used at the lowest dose that provides adequate relief of symptoms, and attempts to discontinue their use should be considered periodically," said study co-author Dr. John DiBaise, professor of medicine at the Mayo Clinic in Scottsdale, Ariz. According to Harvard Medical School, billions of dollars are spent annually on antacid drugs in an attempt to combat heartburn, ulcers and gastroesophageal reflux disease, also known as GERD. Old standbys such ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Rabeprazole, Esomeprazole, Zegerid, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Prevacid OTC

Take Heartburn Medicines Before Breakfast for Best Effect

Posted 11 Jun 2014 by Drugs.com

WEDNESDAY, June 11, 2014 – Many people with heartburn aren't taking their acid-reducing medicine at the right time, which makes the drugs less effective and wastes money, according to new research. Only about one-third of those buying these medications – such as Nexium, Prevacid and Prilosec – over-the-counter used them properly compared to just under half of those who were prescribed the drugs by their primary care doctor. Those who were given a prescription by a gastroenterologist were most likely to use the drugs as they're supposed to be used, with seven out of 10 taking the drugs properly, according to the study. These drugs are activated once in the body, said the study's senior author, Dr. M. Michael Wolfe, a gastroenterologist and chair of the department of medicine at MetroHealth System. "In order to activate the medicine, you must eat. For that reason, you take it before ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Rabeprazole, Esomeprazole, Zegerid, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Prevacid OTC

Acid-Reflux Drugs Tied to Lower Levels of Vitamin B-12

Posted 10 Dec 2013 by Drugs.com

TUESDAY, Dec. 10, 2013 – People who take certain acid-reflux medications might have an increased risk of vitamin B-12 deficiency, according to new research. Taking proton pump inhibitors (PPIs) to ease the symptoms of excess stomach acid for more than two years was linked to a 65 percent increase in the risk of vitamin B-12 deficiency. Commonly used PPI brands include Prilosec, Nexium and Prevacid. Researchers also found that using acid-suppressing drugs called histamine-2 receptor antagonists – also known as H2 blockers – for two years was associated with a 25 percent increase in the risk of B-12 deficiency. Common brands include Tagamet, Pepcid and Zantac. "This study raises the question of whether or not people who are on long-term acid suppression need to be tested for vitamin B-12 deficiency," said study author Dr. Douglas Corley, a research scientist and gastroenterologist at ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Dexilant, Prevacid, Pepcid, Lansoprazole, Aciphex, Famotidine, Heartburn Relief, Vitamin B12 Deficiency, Zantac 150, Rabeprazole, Esomeprazole, Zegerid

Chronic Heartburn May Raise Odds for Throat Cancer: Study

Posted 23 May 2013 by Drugs.com

THURSDAY, May 23 – People who suffer from frequent heartburn may be at increased risk for cancers of the throat and vocal cords even if they don't smoke or drink alcohol, a new study says. Interestingly, common over-the-counter antacids seemed to protect against these cancers while prescription medications such as Prilosec, Nexium and Prevacid didn't, the researchers said. "There has been a controversy about whether heartburn contributes to cancers of the larynx or pharynx," said lead researcher Scott Langevin, a postdoctoral research fellow at Brown University in Providence, R.I. "And we found out that it does elevate the risk of these cancers. There is about a 78 percent increase in the risk for cancer in people who experience heavy heartburn," he said. "This is important in figuring out who to monitor more closely." The other finding, which Langevin called "surprising," was the ... Read more

Related support groups: Cancer, GERD, Omeprazole, Nexium, Prilosec, Indigestion, Prevacid, Lansoprazole, Tums, Milk of Magnesia, Caltrate, Calcium Carbonate, Esomeprazole, Sodium Bicarbonate, Phillips' Milk of Magnesia, Prilosec OTC, Mylanta, Magnesium Hydroxide, Rolaids, Maalox

Health Tip: Before You Take This Heartburn Medication...

Posted 5 Apr 2013 by Drugs.com

-- A proton pump inhibitor, a drug commonly taken for heartburn, may cause side effects. The American Academy of Family Physicians lists these factors to consider before using a proton pump inhibitor (PPI): If you're a postmenopausal woman, talk with your doctor because a PPI could increase your risk for bone fractures. If you've been treated for a C. difficile infection, check with your doctor because PPIs may increase the risk of the infection returning. If you have problems with your immune system or are elderly, check with your doctor because PPIs may increase the risk of pneumonia. Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Rabeprazole, Esomeprazole, Zegerid, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Protonix IV

Heartburn Meds May Often Be Taken for Too Long, at Too-High Doses

Posted 22 Feb 2013 by Drugs.com

FRIDAY, Feb. 22 – U.S. veterans with chronic heartburn are often prescribed higher-than-recommended doses of medicines to control the condition and many are kept on the drugs far too long, according to a new study. Researchers looked at 1,600 veterans who were diagnosed with chronic heartburn – also known as gastroesophageal reflux disease (GERD) – and prescribed a type of drug called a "proton pump inhibitor," such as Prilosec (omeprazole). GERD arises when the ring of muscle between the esophagus and stomach fails to close properly, allowing stomach acids to splash up into the esophagus. The main symptom is chronic heartburn. These drugs – which also include Prevacid (lansoprazole) and Nexium (esomeprazole) – are among the most widely used drugs in the United States and provide relief for many patients with chronic heartburn. However, proper prescribing is required to avoid ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Rabeprazole, Esomeprazole, Zegerid, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Protonix IV

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