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Heartburn Drugs, Plavix Seem Safe to Take Together

Posted 6 Oct 2010 by Drugs.com

WEDNESDAY, Oct. 6 – Heartburn drugs known as proton-pump inhibitors can safely be taken with the blood thinner Plavix, a new study indicates. There has been concern that these medications, called PPIs, might interfere with the ability of Plavix (clopidogrel) to do its job. "This is reassuring data that there is not any clinically significant interaction between clopidogrel and PPIs," said lead researcher Dr. Deepak L. Bhatt, chief of cardiology at the Veterans Affairs Boston Healthcare System. "This is contrary to prior observational, non-randomized studies that showed that if you took clopidogrel and a PPI, it blunted the ability of clopidogrel to protect from things like heart attack," he noted. In addition, this is the first randomized clinical trial to show that prophylactic use of PPIs for patients taking Plavix reduces gastrointestinal bleeding, he said. Doctors often prescribe ... Read more

Related support groups: Plavix, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Vimovo, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Kapidex, Dexlansoprazole, Zegerid OTC, Omeprazole/Sodium Bicarbonate

Plavix, Heartburn Drug Safe to Take Together: Study

Posted 21 Sep 2010 by Drugs.com

TUESDAY, Sept. 21 – A new study finds it's safe to take the blood thinner Plavix with proton-pump inhibitors like Nexium, contrary to recent research that said the combination compromised Plavix's effectiveness. "We looked into this highly debated area of clopidogrel [Plavix] and proton-pump inhibitors," said lead researcher Dr. Mette Charlot from the department of cardiology at Copenhagen University Hospital Gentofte in Hellerup, Denmark. "We did not find any evidence of drug interaction." Proton-pump inhibitors are heartburn drugs. Doctors often prescribe the two drugs in combination to prevent clotting and reduce the risk of stomach bleeding, which can be a serious complication for patients taking Plavix, the researchers said. This study is larger than studies that found an interaction between the drugs, and this data included patients who were taking PPIs but not Plavix, Charlot ... Read more

Related support groups: Plavix, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Clopidogrel, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Vimovo, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Kapidex, Dexlansoprazole, Zegerid OTC

FDA Warns of Fracture Risk With Popular Heartburn Drugs

Posted 26 May 2010 by Drugs.com

TUESDAY, May 25 – Blockbuster heartburn medications such as Prevacid, Prilosec and Nexium will now carry a warning on their labels linking the drugs to a heightened risk for fractures, the U.S. Food and Drug Administration announced late Tuesday. The label will advise consumers to use this class of medicines, called proton pump inhibitors (PPIs), carefully, because high doses have been associated with an increased risk of fractures of the hip, wrist and spine, the agency said. PPIs, which include prescription and over-the-counter drugs, work by blocking stomach acid from being produced. However, as with any drug, this benefit comes with some risk, the FDA said. "Epidemiology studies suggest a possible increased risk of bone fractures with the use of proton pump inhibitors for one year or longer, or at high doses," Dr. Joyce Korvick, deputy director for safety in FDA's Division of ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Protonix IV, Omeprazole/Sodium Bicarbonate, Prevacid NapraPAC, Prevacid NapraPAC 500, Lansoprazole/Naproxen, Nexium IV

Stomach Acid Drugs Come with Dangers, Studies Show

Posted 10 May 2010 by Drugs.com

MONDAY, May 10 – Proton pump inhibitors such as Prilosec and Nexium are among the most commonly prescribed drugs in the United States, but several new studies warn that the popular stomach acid reducers are showing the potential for serious side effects. Five studies and an editorial in the May issue of the Archives of Internal Medicine explore the side effects associated with proton pump inhibitors, including bone fractures among older women and Clostridium difficile infections that can cause life-threatening diarrhea and gastrointestinal upset in older people. Overall, proton pump inhibitors are safe, experts stressed. Even so, evidence suggests the drugs are being prescribed unnecessarily and that potential side effects are not being taken seriously enough. "Generally speaking, proton pump inhibitors are safe medications. Proton pump inhibitors are commonly used and generally very ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Protonix IV, Omeprazole/Sodium Bicarbonate, Prevacid NapraPAC, Prevacid NapraPAC 500, Lansoprazole/Naproxen, Nexium IV

Reflux Drugs OK With Blood Thinners

Posted 12 Jan 2010 by Drugs.com

TUESDAY, Sept. 1 – Antacids don't interfere with anti-clotting drugs such as Plavix and Effient in patients who have suffered a heart attack or unstable angina, a new study finds. The results counter other studies that concluded that a class of antacids known as proton pump inhibitors (PPIs) could block the effect of anti-clotting drugs. Doctors often prescribe PPIs along with anti-clotting drugs to reduce the risk of gastrointestinal bleeding. "The current findings provide some reassurance to clinicians that PPIs and clopidogrel [Plavix] can be safely combined in patients in whom there is a strong indication to use both drugs," said lead researcher Dr. Michelle O'Donoghue, an investigator in the TIMI Study Group at Brigham and Women's Hospital in Boston. As to why the findings differ from earlier results, O'Donoghue said the answer may lie in the patients themselves and in the type of ... Read more

Related support groups: Plavix, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Omeprazole/Sodium Bicarbonate, Protonix IV, Prevacid NapraPAC 500, Lansoprazole/Naproxen, Prevacid IV

Right Match of Drug, Doctor Can Boost Reflux Outcomes

Posted 12 Jan 2010 by Drugs.com

FRIDAY, Aug. 21 – Chronic heartburn caused by acid reflux is one of the most common complaints among Americans, and a new study outlines which approaches appear to work best to ease patients' suffering. The Danish study found that people with the condition – formally called gastroesophageal reflux disease (GERD) – typically feel best when placed on medications called proton pump inhibitors (PPIs) by a doctor with whom they have a good rapport. "The treatment we have isn't always perfect," conceded Dr. Maria T. Abreu, professor of medicine and chief of the division of gastroenterology at the University of Miami Miller School of Medicine, who was not involved in the study. She agreed that communicating well with patients can go a long way toward increasing their satisfaction, because reflux treatments don't always relieve all symptoms. If doctors said that up front, patients "might be ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Prevacid, Pepcid, Lansoprazole, Aciphex, Famotidine, Heartburn Relief, Zegerid, Rabeprazole, Pepcid AC, Zantac 150, Esomeprazole, Pepcid Complete

How Safe Are Popular Reflux Drugs?

Posted 1 Dec 2009 by Drugs.com

WEDNESDAY, Nov. 4 – Millions of Americans take drugs like Nexium, Prevacid and Prilosec to ease the erosive effects of acid reflux, but do these medicines put patients at risk for other health problems? Experts remain divided on the potential dangers these common prescription medications might pose. The drugs belong to a class of pharmaceuticals called "proton pump inhibitors," or PPIs, which are generally considered safe and effective. But lately these acid-reducing medications have been the subject of studies linking their use to a number of health risks, from an increased rate of hip fracture to a greater likelihood of diarrhea and community-acquired pneumonia. Dr. Kenneth W. Altman, an associate professor of otolaryngology at Mount Sinai School of Medicine in New York City, draws attention to some of the potential consequences of PPI use in a commentary published in the November ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Protonix IV, Omeprazole/Sodium Bicarbonate, Prevacid NapraPAC, Prevacid NapraPAC 500, Lansoprazole/Naproxen, Nexium IV

Heartburn Drugs Can Thwart Popular Blood Thinner

Posted 1 Dec 2009 by Drugs.com

TUESDAY, Nov. 17 – Combining the antacid Prilosec with the popular blood thinner Plavix (clopidogrel) can cut the effectiveness of Plavix by half, putting patients at risk for heart attack or stroke, according to health officials. "These recommendations are based upon recently submitted studies by the manufacturer of clopidogrel [Sanofi-Aventis and Bristol-Myers Squibb]," Mary Ross Southworth, deputy director for safety with the U.S. Food and Drug Administration's Division of Cardiovascular and Renal Products, said during a morning press conference. "The results of those studies are to avoid the combination of those two medications," she said, adding that the tandem should be avoided even if the two drugs are taken hours apart. Combining the two drugs is common because Plavix can upset the stomach. The FDA said patients taking Plavix can take alternatives to Prilosec, such as Mylanta, ... Read more

Related support groups: Plavix, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Omeprazole/Sodium Bicarbonate, Protonix IV, Prevacid NapraPAC 500, Lansoprazole/Naproxen, Prevacid IV

Certain Reflux Drugs Tied to Higher Post-Angioplasty Death Rate

Posted 1 Dec 2009 by Drugs.com

MONDAY, Nov. 16 – People taking the acid reflux drugs Prilosec or Protonix in combination with blood thinners have a higher risk for death after angioplasty than people who don't take the two popular antacids, a new study has found. The people in the study, which is being presented Monday at the annual meeting of the American Heart Association in Orlando, Fla., were undergoing what doctors call "percutaneous coronary intervention," or PCI, a common procedure used to widen a narrowed artery. PCI typically involves balloon angioplasty followed by the insertion of a drug-emitting stent, a tiny mesh tube, to keep the vessel open. The new study does not prove that taking popular antacids, or reflux drugs, known as proton pump inhibitors (PPIs), along with clot-busting agents such as clopidogrel (Plavix) caused the increased mortality, one expert noted. "All this shows is that people taking ... Read more

Related support groups: Plavix, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Prevacid, Clopidogrel, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Omeprazole/Sodium Bicarbonate, Protonix IV, Prevacid NapraPAC 500, Prevacid IV

FDA Medwatch Alert: Omeprazole (marketed as Prilosec and generic products), Esomeprazole (marketed as Nexium)

Posted 11 Dec 2007 by Drugs.com

[UPDATE 12/11/2007] FDA informed healthcare professionals of the issuance of the Agency's follow-up communication regarding its review of safety data for the drugs omeprazole and esomeprazole that raised concerns about a potential increased risk of heart problems for patients treated with these drugs. The Agency conducted a comprehensive review of the data from two studies that were submitted to FDA. FDA continues to believe that long-term use of omeprazole or esomeprazole is not likely to be associated with an increased risk of heart problems and recommends that healthcare providers continue to prescribe and patients continue to use these products in the manner described in the labeling for the two products. See the "Update of Safety Review" for information regarding the two studies that were reviewed.[Posted August 09, 2007] FDA issued an early communication about the ongoing review ... Read more

Related support groups: Nexium, Prilosec, Prilosec OTC, Nexium IV

FDA Medwatch Alert: Omeprazole (marketed as Prilosec and generic products)

Posted 9 Aug 2007 by Drugs.com

FDA issued an early communication about the ongoing review of new safety data for the proton pump inhibitors, Prilosec and Nexium. The new safety data was from two small long-term clinical studies in patients with severe gastroesophageal reflux disease (GERD). In both studies, patients were randomly assigned to receive treatment with a drug (either omeprazole or esomeprazole) or to have surgery to control their GERD. The results from the study of Prilosec and analyses from an ongoing study of Nexium raised concerns that long-term use of Prilosec or Nexium may have increased the risk of heart attacks, heart failure, and heart-related sudden death in those patients taking either one of the drugs compared to patients who received surgery. After reviewing these and other data submitted by the company, FDA's preliminary conclusion at this time, is that collectively, these data do not suggest ... Read more

Related support groups: Prilosec, Prilosec OTC

Plavix Plus Heartburn Drugs May Hike Heart Risk

Posted 28 Jan 2009 by Drugs.com

WEDNESDAY, Jan. 28 – People taking the clot-preventing drug Plavix and an acid-reducing proton pump inhibitor medication after a heart attack have a dramatically higher risk of a second heart attack than those taking Plavix alone, a Canadian study finds. That increased risk could have enormous public health implications. Proton pump inhibitors such as Prilosec and Prevacid are among the most widely prescribed drugs, and Plavix (clopidogrel) is the second highest-selling drug in the world, the researchers said. The Canadian study of 13,636 people hospitalized with heart attacks between 2002 and 2007 was started as a response to basic science studies showing that the acid-lowering drugs turned off Plavix, said Dr. David N. Juurlink, head of the division of clinical pharmacology and toxicology at Sunnybrook Health Sciences Centre in Toronto. "We linked prescribing data with hospital data ... Read more

Related support groups: Plavix, Prilosec, Prevacid, Prilosec OTC

Powerful Antacid Drugs Raise Fracture Risk

Posted 11 Aug 2008 by Drugs.com

MONDAY, Aug. 11 – New Canadian research shows that long-term use of proton pump inhibitors for acid reflux, peptic ulcers and related disorders elevates the risk of osteoporosis-related fractures. This is now the third large study finding an increased risk of such fractures in people who use these medications. This latest study, reported in the current issue of the Canadian Medical Association Journal, found the longest period of time from starting the drugs to seeing problems emerge. Physicians and patients may need to curb their enthusiasm for prescribing proton pump inhibitors, which have surged in popularity, experts said. "Almost all of us gastroenterologists and internists have become complacent about the use of these medications," said Dr. Felice Schnoll-Sussman, director of research at the Jay Monahan Center for Gastrointestinal Health, Weill Cornell Medical Center at New York ... Read more

Related support groups: Nexium, Prilosec, Protonix, Prevacid, Aciphex, Prevacid NapraPAC

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