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Drug May Prevent Pancreatitis After Digestive Procedure
Posted 11 Apr 2012 by Drugs.com
WEDNESDAY, April 11 – A simple anti-inflammatory drug significantly cuts the risk of painful pancreatitis after patients undergo a specialized scope exam of the digestive tract, a new study suggests. Researchers found that a single dose of indomethacin administered rectally after the procedure – known as ERCP (endoscopic retrograde cholangiopancreatography) – slashed the incidence of pancreatitis to 9.2 percent, compared with 16.9 percent in patients who received a placebo. It also reduced the severity of post-ERCP infection. Of the 602 patients studied, moderate-to-severe pancreatitis developed in only 4.4 percent of the indomethacin group, compared with 8.8 percent among placebo patients. "This is a very specific type of pancreatitis that occurs as a result of the ERCP, which is done an estimated 500,000 times annually," said study author Dr. B. Joseph Elmunzer, an assistant ... Read more
Related support groups: Indomethacin, Pancreatitis, Indocin, Indocin IV, Indocin SR
Endoscopy May Be Better Than Surgery for Severe Pancreatic Infection
Posted 13 Mar 2012 by Drugs.com
TUESDAY, March 13 – Patients with infected severe pancreatitis fare better if they undergo a less invasive endoscopic procedure rather than surgery, a new study finds. The small, preliminary trial of 20 patients with infected necrotizing pancreatitis found that those who underwent endoscopic transgastric necrosectomy (removal of the pancreatic tissue) were less likely to die or experience major complications than those who had surgical necrosectomy. Five of the 20 patients died – 10 percent of those in the endoscopy group compared with 40 percent of those in the surgery group. All deaths were caused by multiple organ failure. Major complications occurred in 20 percent of patients in the endoscopy group and 80 percent of those in the surgery group, according to the researchers. "Acute pancreatitis is a common and potentially lethal disorder. In the United States alone, more than 50,000 ... Read more
Related support groups: Pancreatitis
Popular Diabetes Drugs May Raise Pancreatic Cancer Risk, Study Suggests
Posted 22 Sep 2011 by Drugs.com
THURSDAY, Sept. 22 – People with type 2 diabetes taking the drugs Januvia or Byetta might have an increased risk of developing pancreatitis and pancreatic cancer, a preliminary study suggests. The study also found that Byetta (exenatide) may raise the risk of thyroid cancer. Although the links aren't conclusive, they merit further investigation, the researchers noted. "We have raised concern that there may be a link, but we haven't confirmed it," said lead researcher Dr. Peter Butler, director of the Larry L. Hillblom Islet Research Center at the University of California, Los Angeles. "We need to do more work to figure out whether this is real or not." Both drugs help control blood sugar levels by encouraging production of a hormone called glucagon-like peptide 1 (GLP-1). Januvia (sitagliptin) and Byetta, an injectable drug, are a new way of treating type 2 diabetes, and they ... Read more
Related support groups: Diabetes, Type 2, Januvia, Byetta, Pancreatitis, Pancreatic Cancer
Abbott Receives FDA Approval for Creon to Include Dosing Information for Patients With Chronic Pancreatitis and Pancreatectomy
Posted 5 May 2010 by Drugs.com
ABBOTT PARK, Ill.., May 3 /PRNewswire-FirstCall/ – Abbott (NYSE:ABT) today announced that the U.S. Food and Drug Administration (FDA) approved the supplemental New Drug Application (sNDA) for CREON® (pancrelipase) Delayed-Release Capsules that now includes dosing guidance in the prescribing information specific to patients with limited production of enzymes in the pancreas (exocrine pancreatic insufficiency) due to chronic pancreatitis (CP) or removal of the pancreas (pancreatectomy). Prior to this FDA approval, dosing guidance for medications such as CREON was based on patients with cystic fibrosis. Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of digestive enzymes made by the pancreas. Patients with chronic pancreatitis or those who have had their pancreas removed (to manage conditions of the pancreas such as CP, pancreatic cancer or ... Read more
Related support groups: Pancreatitis, Creon 10, Creon 20, Creon 5
Study Links Smoking to Increased Risk of Pancreatitis
Posted 23 Mar 2009 by Drugs.com
MONDAY, March 23 – Smoking may increase your risk of pancreatitis, an inflammation of the pancreas that causes abdominal pain. It's believed that gallstone disease and excess alcohol consumption can cause pancreatitis. Smoking is a suspected cause of pancreas damage, but it hasn't been clear whether smoking is an independent risk factor for pancreatitis, according to background information in a study by researchers in Denmark. They analyzed about 20 years of data from 17,905 people to determine if smoking was associated with increased risk of acute or chronic pancreatitis. The researchers said that 58 percent of the 9,573 women and 68 percent of the 8,332 men were current smokers, 15 percent and 19 percent of men were ex-smokers, and 28 percent of women and 13 percent of men had never smoked. By the end of the study, 113 women and 122 men had developed acute (160 cases) or chronic (97 ... Read more
Related support groups: Pancreatitis, Chronic Pancreatitis
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