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Non-Hodgkin's Lymphoma Blog

Related terms: Cancer, Non-Hodgkin's Lymphoma, Histiocytic Lymphoma, Lymphoblastic Lymphoma, Lymphocytic Lymphoma, Lymphoma, Histiocytic, Lymphoma, Lymphoblastic, Lymphoma, Lymphocytic, Lymphoma, Non-Hodgkin's

FDA Approves Imbruvica for Mantle Cell Lymphoma

Posted 13 Nov 2013 by Drugs.com

November 13, 2013 – The U.S. Food and Drug Administration today approved Imbruvica (ibrutinib) to treat patients with mantle cell lymphoma (MCL), a rare and aggressive type of blood cancer. MCL is a rare form of non-Hodgkin lymphoma and represents about 6 percent of all non-Hodgkin lymphoma cases in the United States. By the time MCL is diagnosed, it usually has already spread to the lymph nodes, bone marrow and other organs. Imbruvica is intended for patients with MCL who have received at least one prior therapy. It works by inhibiting the enzyme needed by the cancer to multiply and spread. Imbruvica is the third drug approved to treat MCL. Velcade (2006) and Revlimid (2013) are also approved to treat the disease. “Imbruvica’s approval demonstrates the FDA’s commitment to making treatments available to patients with rare diseases,” said Richard Pazdur, M.D., director of the Office o ... Read more

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Early Stem Cell Transplant May Benefit Some Non-Hodgkin's Lymphoma Patients

Posted 31 Oct 2013 by Drugs.com

THURSDAY, Oct. 31 – Early stem cell transplants do not improve overall survival in high-risk patients with aggressive non-Hodgkin's lymphoma, but may be beneficial for a small group of patients with the very highest risk, according to a new study. Non-Hodgkin's lymphoma is cancer of the white blood cells (lymphocytes). Larger-than-normal lymph nodes and fever are common symptoms. Many patients with this type of cancer relapse after undergoing chemotherapy and require an autologous stem cell transplant. In that procedure, the patient's own stem cells are removed before they receive high-dose chemotherapy and/or radiation. After the chemotherapy, the patient's stem cells are returned to help replenish the body's supply of blood cells. This study of 397 patients in the United States and Canada looked at whether giving patients a stem cell transplant before they relapsed would improve ... Read more

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New Strategy Helps Young Lymphoma Patients Avoid Radiation Treatment

Posted 10 Apr 2013 by Drugs.com

WEDNESDAY, April 10 – A new treatment approach may mean that young people with a form of lymphoma can go without radiation therapy, sparing them side effects or raised cancer risks down the road. In a trial conducted by the U.S. National Cancer Institute, nearly all patients with a form of cancer known as primary mediastinal B-cell lymphoma who received chemotherapy, but did not undergo chest radiation, achieved a full remission. Standard treatment for this cancer typically includes radiation to the chest, the study authors pointed out, but this has been linked to significant harmful effects in the future, particularly for women. "These results are exciting and demonstrate that, using this approach, almost all patients appear to be cured and very few patients require radiation," study co-author Dr. Kieron Dunleavy, of the U.S. National Cancer Institute, said in an agency news release. ... Read more

Related support groups: Lymphoma, Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma

Cancer Chemotherapy Tied to Slight Rise in Risk for Leukemia

Posted 14 Feb 2013 by Drugs.com

THURSDAY, Feb. 14 – Chemotherapy can be a lifesaver for thousands of cancer patients, but a new study suggests that it might slightly raise the odds for a type of leukemia later in life. Over the past 30 years, the risk for acute myeloid leukemia (AML) has increased for patients who underwent chemotherapy for certain forms of cancer, particularly non-Hodgkin lymphoma, the new study found. On the other hand, the researchers from the U.S. National Cancer Institute said other cancer survivors may have a reduced risk for AML due to a change in chemotherapy agents that occurred decades ago. One expert not connected to the study stressed that cancer patients need to put the findings into perspective. "It's important to realize that the risk of developing acute myeloid leukemia related to prior chemotherapy is small and increases with the number of chemotherapy treatments given over time," ... Read more

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'Rediscovered' Lymphoma Drug Helps Double Survival: Study

Posted 4 Jun 2012 by Drugs.com

SUNDAY, June 3 – A drug first developed in East Germany in the 1960s has re-emerged as a potent "new" weapon against certain types of non-Hodgkin lymphomas, researchers report. The drug, bendamustine, more than doubled disease progression-free survival when given along with another therapy, rituximab (Rituxan), compared to the drug cocktail that's long been used to fight indolent non-Hodgkin lymphomas. The bendamustine/rituximab combination also left patients with fewer side effects than the older treatment, the trial found. One expert, Dr. Joshua Brody, an assistant professor of hematology/oncology at Mount Sinai School of Medicine in New York City, called the findings "quite exciting." "Simultaneously increasing efficacy and decreasing toxicity is a rare win-win in oncology, and this has already prompted an enormous shift in the way we care for these patients," he said. The findings ... Read more

Related support groups: Rituxan, Rituximab, Non-Hodgkin's Lymphoma, Treanda, Bendamustine

Growing Up Near Livestock Tied to Blood Cancers

Posted 28 Jul 2011 by Drugs.com

THURSDAY, July 28 – Children raised on livestock farms are at significantly greater risk of developing blood cancers – such as leukemia, multiple myeloma and non-Hodgkin's lymphoma – later in life, a new study contends. The researchers pointed out that further studies will be needed before a definitive cause and effect can be established, but they suggested that exposure to particular viruses during childhood may modify the immune system response and result in a higher risk for blood cancer in adulthood. In conducting the study, published in the July 28 online edition of Occupational and Environmental Medicine, researchers compiled information from 114,000 death certificates for people between 35 and 85 years of age who died between 1998 and 2003 in New Zealand. The study found that over the five-year period, more than 3,000 deaths were attributed to blood cancers. Moreover, the ... Read more

Related support groups: Leukemia, Multiple Myeloma, Non-Hodgkin's Lymphoma

Could Dogs' DNA Give Clues to Human Lymphoma?

Posted 13 Apr 2011 by Drugs.com

TUESDAY, April 12 – Scientists are rearranging the genetic information of certain dogs to make the coding human-like as a way to learn more about the genetic causes in people of non-Hodgkin's lymphoma, a cancer that begins in the cells of the immune system. Humans and dogs have a similar genetic makeup and share the same types of cancers, including lymphoma. In purebred dogs of the same breed, however, there are fewer genetic variations than in humans, making it simpler to locate areas of the canine chromosomes that may be involved with cancer. In a new study, North Carolina State University researchers gathered genetic information from dogs with non-Hodgkin's lymphoma and then rearranged, or recoded, the genomes of the dogs into human configuration. The recoded dog genomes were then compared with the genomes of people with non-Hodgkin's lymphoma to identify chromosomes involved in the ... Read more

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U.S. Reports Drop in AIDS-Related Cancers

Posted 12 Apr 2011 by Drugs.com

TUESDAY, April 12 – Cases of AIDS-related cancers have decreased among people with HIV in the United States, but other types of cancer are on the rise in this group, a new study has found. Three cancers – Kaposi's sarcoma, non-Hodgkin's lymphoma and invasive cervical cancer – are among the diseases included in the criteria that the U.S. Centers for Disease Control and Prevention uses to determine whether a person with HIV has developed AIDS. The study, by researchers from the U.S. National Cancer Institute and the U.S. Centers for Disease Control and Prevention, found that these AIDS-defining cancers decreased threefold, from 34,000 cases between 1991 and 1995 to about 10,000 cases between 2001 and 2005. They attributed the decrease to the introduction in 1996 of highly active antiretroviral therapy, which improves immune function, reduces risk of progression to AIDS and greatly ... Read more

Related support groups: HIV Infection, Non-Hodgkin's Lymphoma, Kaposi's Sarcoma

Study Finds Big Strides Made in Treating Leukemia, Lymphoma in Past Decade

Posted 24 Nov 2010 by Drugs.com

WEDNESDAY, Nov. 24 – Clinicians have made remarkable advances in treating blood cancers with bone marrow and blood stem cell transplants in recent years, significantly reducing the risk of treatment-related complications and death, a new study shows. Between the early 1990s and 2007, there was a 41 percent drop in the overall risk of death in an analysis of more than 2,500 patients treated at Fred Hutchinson Cancer Center in Seattle, a leader in the field of blood cancers and other malignancies. Researchers from the Fred Hutchinson Cancer Center, who conducted the study, also noted dramatic decreases in treatment complications such as infection and organ damage. The study was published in the Nov. 24 issue of the New England Journal of Medicine "We have made enormous strides in understanding this very complex procedure and have yielded quite spectacular results," said study senior ... Read more

Related support groups: Hairy Cell Leukemia, Leukemia, Chronic Myelogenous Leukemia (CML), Lymphoma, Chronic Lymphocytic Leukemia (CLL), Acute Myeloid Leukemia, Non-Hodgkin's Lymphoma, Acute Lymphoblastic Leukemia, Cutaneous T-cell Lymphoma, Follicular Lymphoma, Acute Lymphocytic Leukemia, Hodgkin's Lymphoma, Acute Promyelocytic Leukemia, Acute Nonlymphocytic Leukemia, Infection Prophylaxis, Chronic Lymphocytic Leukemia, Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma, Chronic Eosinophilic Leukemia, Meningeal Leukemia, Burkitt Lymphoma, Acute Myeloblastic Leukemia

Children of Older Dads at Higher Risk of Non-Hodgkin's Lymphoma

Posted 9 Jun 2010 by Drugs.com

WEDNESDAY, June 9 – Children born to older fathers are at increased risk for non-Hodgkin's lymphoma, a new study has found. Researchers analyzed data on 110,999 California women and found that those born to fathers older than 40 had a 59 percent greater risk of non-Hodgkin's lymphoma (cancer of the blood and immune system) than those born to fathers younger than 25. The study, which appears online and in the June 15 print issue of the American Journal of Epidemiology, is one of the first to examine the link between parents' age and their adult children's risk of non-Hodgkin's lymphoma, the authors said. The findings add to the growing evidence that a father's age may have a significant effect on a child's health, said study author Yani Lu, of the City of Hope research and treatment center in Duarte, Calif. For example, other studies have found that children of older fathers may be more ... Read more

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Lifestyle Affects Survival in Non-Hodgkin's Lymphoma

Posted 22 May 2010 by Drugs.com

FRIDAY, May 21 – Among patients with non-Hodgkin's lymphoma, those who smoked, drank alcohol or were obese before receiving their diagnosis are more likely to die of the disease than others, researchers say. For example, patients who smoked for at least 20 years are 76 percent more likely to die than those who never smoked. And obese patients – those who are a step beyond overweight – are 32 percent more likely to die than those of normal weight, according to the new study, led by Dr. James Cerhan, a cancer epidemiologist with the Mayo Clinic. Alcohol use also boosts the risk of death, although drinking seems to actually lower the risk that people will develop non-Hodgkin's lymphoma in the first place, the study authors noted. "This now raises the hypothesis that changing these behaviors after diagnosis might improve survival, but this needs to be tested in a clinical study," Cerhan ... Read more

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Genetic Clues May Point to Better Lymphoma Treatments

Posted 6 Jan 2010 by Drugs.com

WEDNESDAY, Jan. 6 – New research into the genetic causes of a form of non-Hodgkin's lymphoma could lead to novel treatments, suggest researchers from the U.S. National Institutes of Health. Their new study reports on how lymphoma cancer cells manage to survive. The type of cancer in question, known as diffuse large B-cell lymphoma, develops in B cells, which are part of the immune system and help the body fend off attackers. Diffuse large B-cell lymphoma accounts for about a third of newly diagnosed non-Hodgkin's lymphoma cases, the researchers noted in a news release from the U.S. National Cancer Institute. The research, published Jan. 7 in Nature, pinpoints how signaling pathways work within lymphoma cells to allow them to survive. The researchers also explored genetic mutations that play a role in the process. "This study opens up a wealth of therapeutic opportunities for this type ... Read more

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Kids Who Beat Cancer Still Face Heart Risks

Posted 9 Dec 2009 by Drugs.com

WEDNESDAY, Dec. 9 – Survivors of childhood cancer have a significantly increased risk for developing heart disease as young adults, a new study finds. The finding came from an analysis of data on 14,358 five-year cancer survivors who were diagnosed before age 21 and 3,899 siblings of cancer survivors. The cancers were leukemia, brain cancer, Hodgkin's lymphoma, non-Hodgkin's lymphoma, kidney cancer, neuroblastoma, soft tissue carcinoma or bone cancer. The study found that young adult survivors of these childhood cancers are much more likely than others in their age group to have cardiovascular problems, including heart failure, heart attack, heart inflammation and heart valve abnormalities, for up to 30 years after being treated for cancer. They also found that the risk was associated with lower exposure to chemotherapy and radiation treatment than previously thought. "Young adults who ... Read more

Related support groups: Hairy Cell Leukemia, Leukemia, Chronic Myelogenous Leukemia (CML), Renal Cell Carcinoma, Brain Tumor, Chronic Lymphocytic Leukemia (CLL), Osteosarcoma, Acute Myeloid Leukemia, Non-Hodgkin's Lymphoma, Glioblastoma Multiforme, Acute Lymphoblastic Leukemia, Pituitary Tumor, Acute Lymphocytic Leukemia, Hodgkin's Lymphoma, Soft Tissue Sarcoma, Malignant Glioma, Acute Promyelocytic Leukemia, Anaplastic Oligodendroglioma, Infection Prophylaxis, Chronic Lymphocytic Leukemia, Acute Nonlymphocytic Leukemia

Immune-Based Lymphoma Treatment Shows Promise

Posted 31 May 2009 by Drugs.com

SUNDAY, May 31 – In a new study, patients with follicular non-Hodgkin lymphoma who received a vaccine made from their own cancer cells went more than 44 months before relapsing, compared to only 30.6 months for those who didn't get the vaccine. The vaccine trial was one of several studies from the new frontier of "personalized medicine" presented Sunday at the American Society of Clinical Oncology (ASCO) annual meeting, in Orlando, Fla. The approach aims to hit cancer hard by tailoring treatments to the patient's own genetics or disease, among other factors. The lymphoma study differs from other vaccine trials in that the tool was patient-specific, study author Dr. Stephen Schuster, an associate professor at the University of Pennsylvania School of Medicine, explained at a Sunday news conference. The findings could signal a whole new direction in how vaccines are used against cancer, ... Read more

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Genes May Predict Lymphoma Treatment Outcome

Posted 26 Nov 2008 by Drugs.com

WEDNESDAY, Nov. 26 – Gene activity patterns can tell doctors whether people with a certain type of non-Hodgkin lymphoma have a better chance of survival with treatment, according to a new study. Three different signatures of gene activity, or expression – a measure of the biological activity of a gene – have been identified in people with diffuse large B-cell lymphoma (DLBCL). One signature, stromal-2, was linked to poor prognosis. In studying thousands of genes in DLBCL tumors, the researchers determined that nonmalignant immune and structural cells lying near the tumor cells also have a great effect on how well patients respond to therapy. "These biological variations are significant in patients treated with the current standard of care," study leader Dr. Louis M. Staudt of the U.S. National Cancer Institute, said in a news release issued by the organization. "Our results provide ... Read more

Related support groups: Non-Hodgkin's Lymphoma

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