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Migraine, Chronic Back Pain Tied to Higher Suicide Risk

Posted 1 day 4 hours ago by Drugs.com

WEDNESDAY, May 22 – People who endure chronic migraines or back pain are more likely to attempt suicide, whether or not they also suffer from depression or another psychiatric condition, according to a new study. "Clinicians who are seeing patients with certain pain conditions should be aware they are at increased risk of suicide," said study co-author Mark Ilgen, of the Veterans Affairs Serious Mental Illness Treatment Resource and Evaluation Center in Ann Arbor, Mich. "Although undoubtedly psychiatric factors are important, there might be aspects of the pain that in and of themselves increase a person's risk," Ilgen said. "There might be something about someone with significant pain that puts them at increased risk." The wide-ranging study, published online May 22 in the journal JAMA Psychiatry, involved more than 4.8 million people who received care from the U.S. Veterans Health ... Read more

Related support groups: Back Pain, Migraine

Having Both Migraines, Depression May Mean Smaller Brain

Posted 1 day 4 hours ago by Drugs.com

WEDNESDAY, May 22 – Migraines and depression can each cause a great deal of suffering, but new research indicates the combination of the two may be linked to something else entirely – a smaller brain. Already aware that people with migraines face double the risk of depression, scientists wanted to determine if having both conditions together affected total brain volume. The difference in size – about 2 percent – isn't alarming, study authors said, but needs further research to determine if the disparity causes any meaningful health effects. "There are several potential explanations why those with both conditions have smaller brain volume," said study author Larus Gudmundsson, a research associate at the Uniformed Services University of the Health Sciences in Bethesda, Md. "There could be some genetic factor driving the whole thing. It could be related to pain mechanisms [in the ... Read more

Related support groups: Depression, Migraine

FDA Approves Generic Zomig and Zomig-ZMT Tablets

Posted 8 days ago by Drugs.com

May 15, 2013 – The U.S. Food and Drug Administration today approved the first generic versions of Zomig and Zomig-ZMT tablets. Zomig (zolmitriptan) belongs to the class of drugs called triptans, and is indicated for the acute treatment of migraine with or without aura in adults. Zomig was first approved in tablet form in November 1997, and Zomig-ZMT orally disintegrating tablets followed in February 2001 as an alternative for patients who have difficulty swallowing conventional tablets. The generic Zolmitriptan Tablets will be available in 2.5 mg and 5 mg strengths, and Apotex, Inc., Glenmark Generics and Mylan Pharmaceuticals, Inc. have indicated that distribution of their products will commence immediately. Apotex and Glenmark will also produce Zolmitriptan Orally Disintegrating Tablets in 2.5 mg and 5 mg strengths. According to IMS Health for the 12 month period ending December ... Read more

Related support groups: Migraine, Zomig, Zolmitriptan, Zomig-ZMT

FDA Medwatch Alert: Valproate Anti-Seizure Products: Drug Safety Communication - Contraindicated for Pregnant Women for Prevention of Migraine Headaches

Posted 17 days ago by Drugs.com

Including valproate sodium (Depacon), divalproex sodium (Depakote, Depakote CP, and Depakote ER), valproic acid (Depakene and Stavzor), and their generics ISSUE: FDA is advising health care professionals and women that the anti-seizure medication valproate sodium and related products, valproic acid and divalproex sodium, are contraindicated and should not be taken by pregnant women for the prevention of migraine headaches. Based on information from a recent study, there is evidence that these medications can cause decreased IQ scores in children whose mothers took them while pregnant. Stronger warnings about use during pregnancy will be added to the drug labels, and valproate’s pregnancy category for migraine use will be changed from "D" (the potential benefit of the drug in pregnant women may be acceptable despite its potential risks) to "X" (the risk of use in pregnant women clearly o ... Read more

Related support groups: Migraine, Seizures, Depakote, Migraine Prevention, Depakote ER, Migraine Prophylaxis, Divalproex Sodium, Valproic Acid, Depakote Sprinkles, Depakene, Stavzor, Depacon

FDA Warns Pregnant Women About Migraine Drugs

Posted 17 days ago by Drugs.com

MONDAY, May 6 – Pregnant women who struggle with migraine headaches should never use medicines containing the ingredient valproate because they can lower the IQ scores of their children, the U.S. Food and Drug Administration said Monday. The new warning will be included on the labels of medicines that contain valproate. These medicines already carry a boxed warning about fetal risk, including birth defects. Valproate products include valproate sodium (Depacon); divalproex sodium (Depakote, Depakote CP, and Depakote ER); valproic acid (Depakene and Stavzor); and their generic versions. "Valproate medications should never be used in pregnant women for the prevention of migraine headaches because we have even more data now that show the risks to the children outweigh any treatment benefits for this use," Dr. Russell Katz, director of the division of neurology products in the FDA's Center ... Read more

Related support groups: Migraine, Seizures, Valproic Acid, Depakene, Stavzor, Depacon

Gene Mutation Linked to Migraines, Researchers Say

Posted 1 May 2013 by Drugs.com

WEDNESDAY, May 1 – Researchers say they've identified a gene mutation associated with a typical form of migraine headache. The causes of migraine headaches are unknown. Between 10 percent and 20 percent of people suffer from the debilitating, recurrent headaches. For the new study, published May 1 in the journal Science Translational Medicine, researchers analyzed the genetics of two families in which migraines were common. They found that many of the migraine sufferers had either a mutation in the casein kinase I delta (CKIdelta) gene or were the children of a parent with the mutation. In laboratory cells, the researchers found that the mutation affects production of the CKIdelta enzyme, which performs vital functions in the brain and body. Further experiments in mice suggested more evidence of a connection between this gene mutation and migraines. "This is the first gene in which ... Read more

Related support groups: Migraine

Drugs Can Sometimes Prevent Migraines, but at a Cost

Posted 29 Apr 2013 by Drugs.com

MONDAY, April 29 – People with severe or frequent migraines often turn to drugs to prevent them. But do the medications work? A new review of preventive treatments shows there is not much difference in the effectiveness of commonly prescribed drugs – they work for some people, in some cases. But there is wide variation in the amount and severity of side effects associated with the drugs. The researchers found that drugs worked better than inactive placebos in reducing monthly migraine attacks. They prevented half or more migraines in 200 to 400 people per 1,000 treated. But many of the medications had side effects so bothersome that sufferers frequently stopped taking them. That could be because none of the drugs used to prevent migraines was designed specifically for that purpose, explained Dr. Jason Rosenberg, director of the Johns Hopkins Headache Center. "So, it's not surprising ... Read more

Related support groups: Migraine, Lisinopril, Metoprolol, Atenolol, Migraine Prevention, Toprol-XL, Migraine Prophylaxis, Atacand, Lopressor, Nadolol, Tenormin, Zestril, Candesartan, Corgard, Sectral, Captopril, Capoten, Acebutolol, Prinivil

Battery-Operated Skin Patch Offers New Option for Migraine Sufferers

Posted 26 Mar 2013 by Drugs.com

TUESDAY, March 26 – The first skin patch approved to treat migraines offers patients an alternative to pills, nasal sprays and injections, the U.S. Food and Drug Administration says. The agency approved the Zecuity patch in January 2013 as a treatment for migraines after they begin. The patch contains sumatriptan (brand name Imitrex), a widely prescribed drug for treating migraines, and wraps around the arm or thigh like an ACE bandage. "Although consumers are familiar with using a patch for, say, smoking cessation, this is the first patch the FDA has approved to treat migraines," Dr. Eric Bastings, a neurologist and deputy director of the FDA's Division of Neurology, said in an agency news release. The battery-powered Zecuity patch uses an electrical current to move the drug through the skin over the course of four hours. A computer chip regulates the charge to ensure the patients ... Read more

Related support groups: Migraine, Zecuity

Brain Differences Seen in People With Migraines

Posted 26 Mar 2013 by Drugs.com

TUESDAY, March 26 – People who suffer migraines may have certain structural differences in pain-related areas of the brain, a new study suggests. Using MRI scans, researchers found that in specific brain regions related to pain processing, migraine sufferers showed a thinner and smaller cortex compared to headache-free adults. The cortex refers to the outer layer of the brain. It's not clear what it all means. But the researchers suspect that certain aspects of brain development may make some people more vulnerable to developing migraines – and that migraine attacks create further changes in the brain. The surface area of the brain "increases dramatically" during fetal development, while the thickness of the cortex changes throughout life, explained senior researcher Dr. Massimo Filippi. "We speculate that migraine patients might have a sort of cortical 'signature' – abnormal ... Read more

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Neurology Group Lists Procedures That May Be Unneeded

Posted 8 Mar 2013 by Drugs.com

FRIDAY, March 8 – Five tests, procedures and treatments that neurologists and their patients should question are outlined in a list released by the American Academy of Neurology (AAN) as part of the Choosing Wisely campaign. "With one in six people affected by a brain disease, such as headache, multiple sclerosis and stroke, our goal is to have patients discuss our Choosing Wisely recommendations regarding medical procedures, therapies, and tests with their neurologists," AAN president Dr. Bruce Sigsbee said in an academy news release. The American Board of Internal Medicine Foundation-led Choosing Wisely campaign involves about 35 medical specialty groups and is intended to encourage patients and doctors to discuss appropriate care while avoiding unnecessary tests and treatments. The AAN is one of 17 medical societies that recently released advice lists. Here are the AAN's five ... Read more

Related support groups: Suboxone, Methadone, Headache, Oxycodone, OxyContin, Hydrocodone, Vicodin, Migraine, Morphine, Norco, Fentanyl, Lortab, Opana, Subutex, Codeine, Multiple Sclerosis, Dilaudid, Ischemic Stroke, Opana ER, Roxicodone

Nerve-Stimulating Device Might Ease Migraines

Posted 6 Feb 2013 by Drugs.com

WEDNESDAY, Feb. 6 – Migraine sufferers in search of a non-medicinal alternative for relief may be encouraged by new Belgian research that suggests that 20 minutes a day of nerve stimulation might cut back on the frequency of attacks. The finding stems from a small study involving 67 migraine patients. All participants were outfitted with a wearable device called a "supraorbital transcutaneous stimulator," or STS, which was placed on the forehead and designed to deliver electrical stimulation to the patient's supraorbital nerve. Use of the stimulator device was found to be "effective and safe as a preventive therapy for migraine," according to the study. Study lead author Dr. Jean Schoenen, of the headache research unit in the department of neurology & GIGA-neurosciences at Liege University, and colleagues described the team's findings in the Feb. 6 online issue of Neurology. Study ... Read more

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No Proof Drugs Ease Kids' Migraines: Study

Posted 28 Jan 2013 by Drugs.com

MONDAY, Jan. 28 – Children and teens who get migraine headaches suffer in multiple ways, missing school and fun time with friends while waiting for the debilitating pain to subside. Now, two new broad reviews of pediatric migraine research point to a troubling conclusion: There is no clear evidence that drugs currently used to treat and prevent headaches among adults do anything much to help similarly afflicted children. The finding stems from a pediatric migraine-treatment investigation conducted by the U.S. Food and Drug Administration (FDA) and a pediatric migraine-prevention study out of the Medical College of Wisconsin in Milwaukee. The results of both analyses are published online Jan. 28 in JAMA Pediatrics. On the migraine prevention front, Wisconsin's Dr. Jeffrey Jackson, a professor of medicine, and colleagues reviewed 21 previously conducted studies (dating up to mid-2012) ... Read more

Related support groups: Migraine, Trazodone, Topamax, Topiramate, Topamax Sprinkle, Oleptro, Topiragen, Desyrel Dividose, Desyrel

Could Lightning Spur Headaches and Migraines?

Posted 25 Jan 2013 by Drugs.com

FRIDAY, Jan. 25 – Lightning is associated with an increased risk of headaches and migraines, a new study suggests. This finding could help chronic sufferers better predict the likelihood of a headache or migraine and begin preventive treatment, the University of Cincinnati researchers said. The study found that chronic sufferers had a 31 percent greater risk of headache and a 28 percent increased risk of migraine on days when lightning struck within 25 miles of their homes. It did not, however, prove a cause-and-effect relationship between lightning and headaches. New-onset headache and migraine increased by 24 percent and 23 percent, respectively, in patients when there was lightning, according to the study published online Jan. 24 in the journal Cephalalgia. "Many studies show conflicting findings on how weather, including elements like barometric pressure and humidity, affect the ... Read more

Related support groups: Headache, Migraine

Study Questions Importance of 'Triggers' in Setting Off Migraines

Posted 23 Jan 2013 by Drugs.com

WEDNESDAY, Jan. 23 – Triggers for migraines may not be as strong as widely believed, a new study suggests, and many people may overestimate their importance in spurring the headaches. The study specifically looked at patients affected by migraine with aura. Auras that accompany migraine include visual disturbances such as flashing lights or wavy lines, according to background information in the study published online Jan. 23 in the journal Neurology. "People with migraine with aura are told to avoid possible triggers, which may lead them to avoid a wide range of suspected factors," study author Dr. Jes Olesen, of the University of Copenhagen in Denmark, explained in a journal news release. "Yet the most commonly reported triggers are stress, bright light, emotional influences and physical effort, which can be difficult to avoid and potentially detrimental, if people avoid all physical ... Read more

Related support groups: Migraine

NuPathe's Zecuity Approved by the FDA for the Acute Treatment of Migraine

Posted 18 Jan 2013 by Drugs.com

CONSHOHOCKEN, PA--(Marketwire - Jan 17, 2013) - NuPathe Inc. today announced that the U.S. Food and Drug Administration (FDA) has approved Zecuity (sumatriptan iontophoretic transdermal system) for the acute treatment of migraine with or without aura in adults. Zecuity is a single-use, battery-powered patch that actively delivers sumatriptan, the most widely prescribed migraine medication, through the skin. Zecuity provides relief of both migraine headache pain and migraine-related nausea (MRN). "The approval of Zecuity represents a major milestone for NuPathe and migraine sufferers," said Armando Anido, CEO of NuPathe. "As the first and only FDA-approved migraine patch, we believe Zecuity will be a game-changing treatment option for millions of migraine patients, especially those with migraine-related nausea. We thank the patients and physicians who participated in our clinical trials ... Read more

Related support groups: Migraine, Sumatriptan

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