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New Drug Shows Promise for Restless Legs Syndrome: Study

Posted 12 Feb 2014 by Drugs.com

WEDNESDAY, Feb. 12, 2014 – For relieving symptoms of restless legs syndrome and slowing its progression, the drug pregabalin (Lyrica) outperformed the current standard medication in a head-to-head comparison, a new study found. Pramipexole (Mirapex), which is commonly used to treat this neurological disease, makes many people worse, said lead researcher Richard Allen, an associate professor of neurology at Johns Hopkins University School of Medicine in Baltimore. Lyrica works just as well and doesn't worsen the condition, Allen said. People with restless legs syndrome – now also known as Willis-Ekbom disease – feel throbbing, creeping or other unpleasant sensations in the legs and an uncontrollable urge to move them. Symptoms occur primarily at night, and most people with restless legs syndrome have trouble falling asleep and staying asleep. Moving the legs relieves the discomfort; ... Read more

Related support groups: Lyrica, Restless Legs Syndrome, Pregabalin

Lyrica May Ease Pain for Depressed Fibromyalgia Patients

Posted 28 Oct 2013 by Drugs.com

MONDAY, Oct. 28 – Fibromyalgia and depression often go hand in hand, and a new study finds that the drug Lyrica helps ease pain in patients being treated for both conditions. Lyrica (pregabalin) is approved in the United States to treat fibromyalgia and nerve pain from diabetes and herpes, but little was known about its safety and effectiveness when also taken with antidepressants, the researchers explained. "For those people with fibromyalgia who also have depression, which is very common, and who take an antidepressant but still have pain, taking [Lyrica] can reduce the severity of the pain while they continue on their antidepressant," said study author Dr. Lesley Arnold, professor of psychiatry and behavioral neuroscience at the University of Cincinnati College of Medicine. "And it appears to be safe and tolerable for most people," Arnold added. Arnold is scheduled to present the ... Read more

Related support groups: Depression, Fibromyalgia, Lyrica

Epilepsy Drugs in Pregnancy May Affect Infants' Fine Motor Skills

Posted 25 Sep 2013 by Drugs.com

WEDNESDAY, Sept. 25 – Young children exposed to epilepsy drugs in the womb are at increased risk of having impaired fine motor skills, according to a new study. Exposure to the drugs in breast milk, however, does not appear to pose a threat. Researchers looked at data collected from Norwegian mothers about their children's language, behavior, and motor and social skills at the ages of 6 months, 18 months and 36 months. The women also provided information on breast-feeding during the first year for the study, which was published online Sept. 23 in the journal JAMA Neurology. Of the children in the study, 223 were exposed to one or more epilepsy drugs in the womb. At age 6 months, 11.5 percent of infants whose mothers took epilepsy drugs during pregnancy had impaired fine motor skills (which involve small muscle movements) compared with less than 5 percent of those who were not exposed ... Read more

Related support groups: Seizures, Klonopin, Lyrica, Clonazepam, Valium, Ativan, Lamictal, Topamax, Depakote, Lorazepam, Epilepsy, Diazepam, Keppra, Tegretol, Lamotrigine, Dilantin, Trileptal, Topiramate, Carbamazepine, Pregabalin

Drugs May Help Relieve Restless Legs Syndrome

Posted 4 Mar 2013 by Drugs.com

MONDAY, March 4 – People suffering from restless legs syndrome may find some relief by taking one of several drugs approved to treat the condition, a new review confirms. The medications, which include Requip (ropinirole), levodopa, Neurontin (gabapentin) and Lyrica (pregabalin), appear to reduce symptoms of the syndrome in more than 60 percent of patients, researchers report. The first two drugs raise dopamine levels in the body, and the last two drugs reduce the amount of calcium reaching brain cells and trigger the production of other chemicals that help reduce pain. Dopamine is a brain chemical that regulates movement and mood. "Physicians and patients now have better information on the effectiveness and harms of two types of drug treatments for patients with at least moderately severe restless legs symptoms in which to guide treatment choices," said review author Dr. Timothy Wilt, ... Read more

Related support groups: Gabapentin, Lyrica, Neurontin, Restless Legs Syndrome, Pregabalin, Requip, Ropinirole, Levodopa, Gralise, Horizant, Requip XL, Requip Starter Kit, Gabarone, Repreve, Fanatrex, ReQuip Follow on Pack, Dopar, ReQuip Starter Pack, Larodopa

Lupin Receives FDA Approval for Generic Lyrica

Posted 6 Jul 2012 by Drugs.com

MUMBAI and BALTIMORE, July 5, 2012/PRNewswire-FirstCall/ --Pharma major, Lupin Ltd., announced today that its subsidiary, Lupin Pharmaceuticals Inc. (collectively, Lupin) has received final approval for its Pregabalin Capsules, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg and 300 mg from the United States Food and Drugs Administration (FDA) to market a generic version of C.P. Pharmaceuticals C.V., Lyrica (pregabalin) capsules. Lupin's Pregabalin Capsules, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg and 300 mg are the AB-rated generic equivalent of Lyrica capsules, which is indicated for neuropathic pain associated with diabetic peripheral neuropathy, post herpetic neuralgia, adjunctive therapy for adult patients with partial onset seizures and fibromyalgia. Lyrica Capsules had annual U.S sales of approximately $1.8 billion for the twelve months ending March 2012 (IMS ... Read more

Related support groups: Lyrica, Pregabalin

FDA Approves Lyrica For The Management Of Neuropathic Pain Associated With Spinal Cord Injury Based On Priority Review

Posted 21 Jun 2012 by Drugs.com

NEW YORK--(BUSINESS WIRE)--Jun 21, 2012 - Pfizer Inc. announced today that the U.S. Food and Drug Administration (FDA) approved the use of Lyrica (pregabalin) capsules CV for the management of neuropathic pain associated with spinal cord injury. Lyrica received a priority review designation for this new indication from the FDA. More than 100,000 patients – approximately 40 percent of the 270,000 patients with spinal cord injury in the United States - suffer from this chronic, complex pain condition. Neuropathic pain associated with spinal cord injury can be severely debilitating and may significantly hinder rehabilitation and the ability to regain function. “This milestone represents an important opportunity for physicians to more effectively manage the debilitating neuropathic pain that often accompanies spinal cord injury,” said clinical study investigator Diana Cardenas, MD, MHA, prof ... Read more

Related support groups: Lyrica, Pregabalin, Neuropathy

Epilepsy Drugs Don't Raise Suicide Risk, Study Shows

Posted 5 Aug 2010 by Drugs.com

WEDNESDAY, Aug. 4 – In 2008, the U.S. Food and Drug Administration required epilepsy medications to bear a warning label about an increased risk of suicidal behaviors. The move came after an agency review of 199 studies that found patients taking the drugs showed about twice the risk of suicidal behavior. But now a study of more than 5 million patients contradicts the FDA's findings. It suggests that the increased risk of suicide has more to do with the conditions for which these drugs are prescribed than the medications themselves. For the study, researchers in Spain and the United States evaluated the health records of primary care patients in England. They found that people with epilepsy who currently use an antiepileptic drug are at no greater risk of suicide-related events than those who aren't taking the medications. "In our opinion, in the long term, it is not the drugs ... Read more

Related support groups: Gabapentin, Lyrica, Lamictal, Neurontin, Topamax, Depakote, Keppra, Tegretol, Lamotrigine, Trileptal, Topiramate, Carbamazepine, Pregabalin, Depakote ER, Levetiracetam, Oxcarbazepine, Divalproex Sodium, Zonisamide, Tegretol XR, Zonegran

FDA Medwatch Alert: Antiepileptic Drugs

Posted 5 May 2009 by Drugs.com

[UPDATE 05/05/2009] FDA notified healthcare professionals that it approved updated labeling for antiepileptic drugs used to treat epilepsy, psychiatric disorders, and other conditions (e.g., migraine and neuropathic pain syndromes). FDA also required development of a medication guide, to be issued to patients each time the product is dispensed. Since issuing safety alerts on December 16, 2008 and January 31, 2008, FDA has been working with the manufacturers of drugs in this class to better understand the suicidality risk. Eleven antiepileptic drugs were included in a pooled analysis of placebo-controlled clinical studies in which these drugs were used to treat epilepsy as well as psychiatric disorders and other conditions. The increased risk of suicidal thoughts or behavior was generally consistent among the eleven drugs, with varying mechanisms of action and across a range of ... Read more

Related support groups: Seizures, Lyrica, Lamictal, Topamax, Depakote, Epilepsy, Keppra, Trileptal, Seizure Prevention, Zonegran, Carbatrol, Depakene, Di-Phen, Felbatol, Gabitril, Gabarone

Common Drug Eases Restless Legs Syndrome

Posted 29 Apr 2009 by Drugs.com

WEDNESDAY, April 29 – Lyrica, a drug used to treat epilepsy, nerve pain, anxiety and fibromyalgia, shows promise in easing the symptoms of restless legs syndrome, a Spanish researcher reports. Some 5 percent to 10 percent of adults in the United States have restless legs syndrome (RLS), a disorder that causes people to feel a compelling need to move their legs, especially while lying down. The condition can have a substantial impact on sleep, daily activities and quality of life, researchers say. "This is the first time this drug is being tried for RLS," said Dr. Diego Garcia-Borreguero, director of the Sleep Research Institute in Madrid. "Pregabalin [Lyrica] is an effective drug for the treatment of RLS – it leads about 60 percent of patients into clinical remission." The drug improves both the sensation and motor symptoms of RLS, Garcia-Borreguero said. He also noted that patients ... Read more

Related support groups: Lyrica, Restless Legs Syndrome

FDA Adds Suicide Warning to Epilepsy Drugs

Posted 16 Dec 2008 by Drugs.com

TUESDAY, Dec. 16 – The U.S. Food and Drug Administration announced Tuesday that it was adding a label warning on heightened suicide risk for users of antiepileptic drugs. The move, which follows the advice last summer of an FDA advisory panel, stops short of slapping the strongest "black box" warning on this class of drugs, which includes widely used medications such as clonazepam (Klonopin), phenytoin (Dilantin) and topiramate (Topamax). "Patients being treated with antiepileptic drugs for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, or any unusual changes in mood or behavior," Dr. Russell Katz, director of the division of neurology products in the FDA's Center for Drug Evaluation and Research, said in an agency news release. But, he added, "patients who are currently taking an antiepileptic medicine should not make ... Read more

Related support groups: Klonopin, Lyrica, Lamictal, Topamax, Depakote, Keppra, Trileptal, Zonegran, Tranxene, Carbatrol, Zarontin, Di-Phen, Mysoline, Felbatol, Gabitril, Gabarone, Tridione, Mesantoin, Peganone

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Neuropathic Pain, Fibromyalgia, Diabetic Neuropathy, Diabetic Nerve Damage, Neuralgia, Persisting Pain, Shingles, Postherpetic Neuralgia, Epilepsy

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