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Kids More Likely Than Adults To Be Resistant to HIV Meds: Study

Posted 27 May 2014 by Drugs.com

TUESDAY, May 27, 2014 – Children born with HIV face a greater risk of developing resistance to life-saving antiretroviral drugs than HIV-infected adults do, according to new research. Antiretroviral drugs are used to treat people infected with HIV, the virus that causes AIDS. "The problem with drug resistance is that once you develop it, it never goes away," study author Dr. Russell Van Dyke, a professor of pediatric infectious diseases at Tulane University School of Medicine, said in a university news release. "Some patients with very resistant virus have no effective treatment options. Resistant virus is the major reason for death among youth" who were born with HIV, he added. The study looked at 450 HIV-infected children across the United States and found that 74 percent were resistant to at least one type of HIV drug, and 30 percent were resistant to two classes of drugs. By ... Read more

Related support groups: HIV Infection, Incivek, Sovaldi, Victrelis, Baraclude, Viread, Kaletra, Tenofovir, Telaprevir, Norvir, Entecavir, Lamivudine, Lexiva, Reyataz, Nevirapine, Norvir Soft Gelatin, Hepsera, Ritonavir, Sofosbuvir, Adefovir

Researchers Describe First 'Functional Cure' of HIV in Baby

Posted 4 Mar 2013 by Drugs.com

SUNDAY, March 3 – A baby born two-and-a-half years ago in Mississippi with HIV is the first case of a so-called "functional cure" of the infection, researchers announced Sunday. Standard tests can no longer detect any traces of the AIDS-causing virus even though the child has discontinued HIV medication. "We believe this is the first well-documented case of a [functional] cure," said study lead author Dr. Deborah Persaud, associate professor of pediatrics in the division of infectious diseases at Johns Hopkins Children's Center in Baltimore. The finding was presented Sunday at the Conference on Retroviruses and Opportunistic Infections, in Atlanta. The child was not part of a study but, instead, the beneficiary of an unexpected and partly unplanned sequence of events that – once confirmed and replicated in a formal study – might help more children who are born with HIV or who at risk ... Read more

Related support groups: HIV Infection, Incivek, Victrelis, Baraclude, Viread, Kaletra, Tenofovir, Telaprevir, Norvir, Entecavir, Reyataz, Nevirapine, Lamivudine, Lexiva, Boceprevir, Hepsera, Prezista, Ritonavir, Epivir, Norvir Soft Gelatin

HIV Drug Combo May Help Prevent Malaria Reinfection

Posted 29 Nov 2012 by Drugs.com

WEDNESDAY, Nov. 28 – Treatment with a combination of certain HIV drugs greatly reduces the risk of recurrent malaria in children with HIV who are also being treated with drugs to prevent the mosquito-borne infection, according to new research. The study included more than 170 HIV-positive infants and children up to 6 years old in Uganda who were receiving anti-malarial drugs and HIV treatment, including either a combination of the protease inhibitors lopinavir and ritonavir, or a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs). Despite the anti-malarial drugs and other preventive measures – such as mosquito nets – the children's risk of developing malaria during their first six months of HIV treatment was more than 40 percent. The risk during that time period was about the same whether the children were taking the protease inhibitors or an NNRTI, the ... Read more

Related support groups: HIV Infection, Malaria, Incivek, Malaria Prevention, Victrelis, Kaletra, Telaprevir, Malaria Prophylaxis, Norvir, Reyataz, Nevirapine, Lexiva, Ritonavir, Prezista, Boceprevir, Norvir Soft Gelatin, Indinavir, Intelence, Sustiva, Edurant

FDA: More Than 150 Antiretroviral Drugs Available Through PEPFAR for Worldwide HIV/AIDS Relief

Posted 23 Jul 2012 by Drugs.com

July 23, 2012 – Today, U.S. Food and Drug Administration (FDA) Commissioner Margaret A. Hamburg announced the agency has approved or tentatively approved a total of 152 antiretroviral drugs in association with the President’s Emergency Plan for AIDS Relief (PEPFAR) to treat those infected with HIV/AIDS in countries that lack the tools needed to fight the AIDS epidemic. The most recent FDA actions in association with PEPFAR were tentative approvals of the following generic drugs: abacavir oral solution (Hetero Labs Ltd. Unit III, July 2, 2012) lopinavir and ritonavir oral solution (Cipla Ltd., June 29, 2012) efavirenz tablets (Edict Pharmaceuticals Private Ltd., June 25, 2012 and Micro Labs Ltd., June 20, 2012) Tentative approval means that although FDA has found that a drug product has met all required manufacturing quality, clinical safety, and efficacy requirements, it cannot be a ... Read more

Related support groups: HIV Infection, Atripla, Incivek, Victrelis, Baraclude, Viread, Tenofovir, Kaletra, Telaprevir, Norvir, Entecavir, Lamivudine, Reyataz, Nevirapine, Lexiva, Epivir, Hepsera, Prezista, Adefovir, Ritonavir

All HIV Patients Should Take Meds Early On, Experts Now Say

Posted 23 Jul 2012 by Drugs.com

MONDAY, July 23 – A new report recommends that physicians begin treating all HIV-positive adults with antiretroviral drugs instead of waiting, at least in countries where the therapy is easily accessible. All HIV-positive patients should take the drugs, even if blood tests reveal that their immune system is healthy, according to the revised guidelines, which were presented Sunday at the International AIDS Conference in Washington D.C., and published in the July 25 issue of the Journal of the American Medical Association. Over the last 25 years, antiretroviral drugs have become stronger, easier to tolerate and simpler to take, the authors of the report explained. "New trial data and drug regimens that have become available in the last two years warrant an update to guidelines for antiretroviral therapy in HIV-infected adults in resource-rich settings," Dr. Melanie Thompson and her 2012 ... Read more

Related support groups: HIV Infection, Incivek, Victrelis, Baraclude, Viread, Kaletra, Tenofovir, Telaprevir, Norvir, Entecavir, Reyataz, Nevirapine, Lamivudine, Lexiva, Boceprevir, Hepsera, Prezista, Ritonavir, Epivir, Norvir Soft Gelatin

Studies Show Value of AIDS Drugs as Prevention

Posted 11 Jul 2012 by Drugs.com

WEDNESDAY, July 11 – Researchers have released the final results of two studies that suggest AIDS drugs can prevent exposed people in Africa from getting infected with HIV by their sexual partners. However, another study indicates that it's a tough job to convince African women who aren't at the highest risk to take preventive medications. In the big picture, the studies show that "we have a new HIV-prevention strategy, one that's quite powerful but also depends on adherence," said Dr. Jared Baeten, an associate professor of global health at the University of Washington, in Seattle. "The next step is figuring out how to motivate people to take it." The studies appeared online July 11 in the New England Journal of Medicine. The general findings of the studies have been previously released, but only now has the research become available in a medical journal after going through a ... Read more

Related support groups: HIV Infection, Incivek, Victrelis, Baraclude, Viread, Kaletra, Tenofovir, Telaprevir, Norvir, Entecavir, Reyataz, Nevirapine, Lamivudine, Lexiva, Boceprevir, Hepsera, Prezista, Ritonavir, Epivir, Norvir Soft Gelatin

Young Men Taking HIV Meds May Be at Risk for Bone Loss

Posted 22 Jun 2012 by Drugs.com

FRIDAY, June 22 – Young men receiving drug treatment for HIV infection are at increased risk for low bone mass, a new study suggests. The findings indicate that these patients should exercise, take vitamin D and be closely monitored in order to reduce their future risk of bone fractures, according to the study, released online in advance of print publication in the journal Clinical Infectious Diseases. The study included about 250 male participants, aged 14 to 25, who underwent whole-body scans to measure their bone density. Some of the men were infected with HIV, the virus that causes AIDS. The participants with HIV had been diagnosed with the infection an average of two years earlier. The HIV-infected males had an average 5 percent to 8 percent lower bone density in the hip and 2 percent to 4 percent lower bone density in the spine than those without HIV. Although the study uncovered ... Read more

Related support groups: HIV Infection, Incivek, Victrelis, Baraclude, Viread, Kaletra, Tenofovir, Telaprevir, Norvir, Entecavir, Reyataz, Nevirapine, Lamivudine, Lexiva, Boceprevir, Hepsera, Prezista, Ritonavir, Epivir, Norvir Soft Gelatin

Taking Anti-HIV Meds Prior to Exposure May Help Prevent Infection

Posted 29 May 2012 by Drugs.com

TUESDAY, May 29 – Preventive antiretroviral treatment appears to be an effective way to help protect high-risk people against HIV infection, a new study suggests. HIV, the virus that causes AIDS, can be transmitted through unprotected sex and contaminated needles. Immediate treatment after HIV exposure can be successful in preventing HIV infection, previous research has found. More recently, several large randomized, controlled trials – the gold standard of medical research, in which people are randomly assigned to treatment or no treatment – have shown that giving antiretroviral drugs before people are exposed may also prevent infection. For the new report, published May 28 in the CMAJ (Canadian Medical Association Journal), researchers reviewed studies published between January 1990 and April 2012 and found that preventive antiretroviral treatment could reduce the risk of HIV ... Read more

Related support groups: HIV Infection, Incivek, Victrelis, Baraclude, Viread, Kaletra, Tenofovir, Telaprevir, Norvir, Entecavir, Reyataz, Nevirapine, Lamivudine, Lexiva, Boceprevir, Hepsera, Prezista, Ritonavir, Epivir, Norvir Soft Gelatin

FDA Medwatch Alert: Victrelis (boceprevir) and Ritonavir-Boosted Human Immunodeficiency Virus (HIV) Protease Inhibitor Drugs: Drug Safety Communication - Drug Interactions

Posted 26 Apr 2012 by Drugs.com

[UPDATED 04/26/2012] FDA notified healthcare professionals that the Victrelis drug label has been revised to state that co-administration of Victrelis (boceprevir), a hepatitis C virus (HCV) protease inhibitor, along with certain ritonavir-boosted human immunodeficiency virus (HIV) protease inhibitors, is not recommended. The findings of a drug-drug interaction study and clinical trial showed that co-administration increased of the possibility of reducing the effectiveness of the medicines, permitting the amount of HCV or HIV virus in the blood to increase. Ritonavir-boosted HIV protease inhibitors include ritonavir-boosted Reyataz (atazanavir), ritonavir-boosted Prezista (darunavir), and Kaletra (lopinavir/ritonavir).   [Posted 02/09/2012] ISSUE: FDA notified healthcare professionals and patients that drug interactions between the hepatitis C virus (HCV) protease inhibitor Victrelis ( ... Read more

Related support groups: Hepatitis C, HIV Infection, Victrelis, Kaletra, Norvir, Reyataz, Ritonavir, Prezista, Boceprevir, Norvir Soft Gelatin, Atazanavir, Emtricitabine/lopinavir/ritonavir/tenofovir, Darunavir, Lopinavir/Ritonavir

FDA Medwatch Alert: Statins and HIV or Hepatitis C Drugs: Drug Safety Communication - Interaction Increases Risk of Muscle Injury

Posted 2 Mar 2012 by Drugs.com

ISSUE: FDA notified healthcare professionals  of updates to the prescribing information concerning interactions between  protease inhibitors and certain statin  drugs. Protease inhibitors and statins taken together may raise the blood levels of statins and increase the risk for muscle injury (myopathy). The most serious form of myopathy, called rhabdomyolysis, can damage the kidneys and lead to kidney failure, which can be fatal. BACKGROUND: Statins are a class of prescription drugs used together with diet and exercise to reduce blood levels of low-density lipoprotein (LDL) cholesterol (“bad cholesterol”). HIV protease inhibitors are a class of prescription anti-viral drugs used to treat HIV. HCV protease inhibitors are a class of prescription anti-viral drugs used to treat hepatitis C infection. RECOMMENDATION: Healthcare professionals should follow the recommendations in the  pr ... Read more

Related support groups: Lipitor, Simvastatin, Crestor, Pravastatin, Atorvastatin, Zocor, Lovastatin, Incivek, Rosuvastatin, Livalo, Red Yeast Rice, Pravachol, Victrelis, Kaletra, Telaprevir, Norvir, Lescol, Reyataz, Lexiva, Boceprevir

FDA Medwatch Alert: Victrelis (boceprevir) and Ritonavir-Boosted Human Immunodeficiency Virus (HIV) Protease Inhibitor Drugs: Drug Safety Communication - Drug Interactions

Posted 10 Feb 2012 by Drugs.com

[Posted 02/09/2012] ISSUE: FDA notified healthcare professionals and patients that drug interactions between the hepatitis C virus (HCV) protease inhibitor Victrelis (boceprevir) and certain ritonavir-boosted human immunodeficiency virus (HIV) protease inhibitors (atazanavir, lopinavir, darunavir) can potentially reduce the effectiveness of these medicines when they are used together. A drug interaction study showed that taking boceprevir (Victrelis) with ritonavir (Norvir) in combination with atazanavir (Reyataz) or darunavir (Prezista), or with Kaletra (lopinavir/ritonavir) reduced the blood levels of the HIV medicines and boceprevir in the body (see Data Summary below). FDA will be updating the Victrelis drug label to include information about these drug interactions. BACKGROUND: Victrelis is a hepatitis C virus (HCV) protease inhibitor used with the medicines peginterferon alfa and ... Read more

Related support groups: Kaletra, Norvir, Reyataz, Ritonavir, Prezista, Norvir Soft Gelatin, Atazanavir, Darunavir, Lopinavir/Ritonavir, Emtricitabine/lopinavir/ritonavir/tenofovir

No Gender-Based Difference Seen in Anti-HIV Drug Response

Posted 20 Sep 2010 by Drugs.com

MONDAY, Sept. 20 – Men and women have the same responses to the anti-HIV drugs darunavir and ritonavir, researchers have found. The new study included 429 HIV-positive patients (287 women and 142 men) at 65 sites in the United States, Puerto Rico and Canada. HIV is the virus that causes AIDS. The participants were given 600 milligrams (mg) of darunavir and 100 mg of ritonavir twice daily. The treatment response rates were 73 percent in women and 73.5 percent in men, the investigators found. Rates of adverse events were also comparable between the sexes. The most common side effects were nausea (5.2 percent of women, 2.8 percent of men), diarrhea (4.5 percent of women, 4.9 percent of men) and rash (2.1 percent of women, 2.8 percent of men). The findings are published in the Sept. 21 issue of the journal Annals of Internal Medicine. The Gender, Race and Clinical Experience (GRACE) study ... Read more

Related support groups: HIV Infection, Kaletra, Norvir, Prezista, Ritonavir, Norvir Soft Gelatin, Lopinavir/Ritonavir, Emtricitabine/lopinavir/ritonavir/tenofovir, Darunavir

Anti-HIV Drugs May Help Prevent Spread of Virus

Posted 27 May 2010 by Drugs.com

THURSDAY, May 27 – People who are HIV-positive can lower their risk for transmitting the virus to their partners by 90 percent by taking antiretroviral drugs, new research has found. Antiretroviral drug therapy helps reduce HIV levels in the infected person's blood, which in turn makes the person less infectious to others. The drugs are commonly taken in the United States by people with HIV, the virus that causes AIDS. In the new research, published online May 26 in The Lancet, investigators studied more than 3,400 heterosexual couples in seven African countries. In each couple, one person was infected with HIV and the other was not. No one in the study was taking antiretroviral drugs. Health workers counseled the couples about preventing HIV transmission and followed up with them for two years. During that time, periodic blood tests measured HIV levels in the blood, and people were ... Read more

Related support groups: HIV Infection, Atripla, Truvada, Baraclude, Viread, Tenofovir, Kaletra, Entecavir, Norvir, Nevirapine, Reyataz, Lexiva, Lamivudine, Adefovir, Hepsera, Combivir, Prezista, Ritonavir, Norvir Soft Gelatin, Epivir

AIDS Drugs Don't Need Routine Lab Monitoring

Posted 9 Dec 2009 by Drugs.com

WEDNESDAY, Dec. 9 – In a finding that has implications for how the AIDS virus is treated in Africa, new research suggests that antiretroviral drugs can be given without routine monitoring by lab tests. But tests of immune-system function might still be a good idea to monitor the progression of the disease and guide the second year of treatment, the study authors report. Patients with HIV, the virus that causes AIDS, often receive drug treatment in Africa without routine laboratory monitoring. In the study, published online Tuesday in advance of publication in a future print issue of The Lancet, researchers tried to determine if that's a bad idea. They studied 3,316 HIV-positive adults who were assigned to monitoring in both the doctor's office and the laboratory or only in the doctor's office. The patients were studied in Uganda and Zimbabwe. "The results clearly show that first-line ... Read more

Related support groups: HIV Infection, Atripla, Truvada, Viread, Tenofovir, Kaletra, Norvir, Lexiva, Reyataz, Prezista, Norvir Soft Gelatin, Ritonavir, Efavirenz, Sustiva, Atazanavir, Emtricitabine, Lopinavir/Ritonavir, Emtriva, Fosamprenavir, Darunavir

FDA Medwatch Alert: Kaletra (lopinavir/ritonavir) Oral Solution

Posted 14 Aug 2007 by Drugs.com

[Posted 08/14/2007] Abbott Laboratories disseminated a Dear Healthcare Provider Letter throughout the world to physicians and pharmacists that prescribe/distribute Kaletra Oral Solution. The letter informed healthcare professionals of an accidental overdose that occurred with a pediatric patient taking Kaletra Oral Solution. The infant received a significantly large dose of Kaletra and subsequently died. Healthcare professionals should pay special attention to accurate calculation of the dose of Kaletra, transcription of the medication order, dispensing information and dosing instructions to minimize the risk for medication errors.[August 13, 2007 - Dear Healthcare Professional Letter - Abbott] Read more

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