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Insulin Resistance Blog

Related terms: Impaired Glucose Tolerance, Impaired Fasting Glucose, Syndrome X

Blog (19)

Insulin Resistance May Lead to Kidney Disease in the Elderly: Study

Posted 8 Mar 2012 by Drugs.com

THURSDAY, March 8 – Elderly people with metabolic syndrome are at increased risk for chronic kidney disease, and insulin resistance may be the central hub that links metabolic syndrome and kidney-function decline, according to a new study. People are diagnosed with metabolic syndrome when they have at least three risk factors for diabetes and heart disease, including: high blood pressure, high blood-sugar (glucose) levels, high triglycerides (fat in the blood), low levels of "good" (HDL) cholesterol and too much abdominal fat. The study included 1,456 people, aged 65 and older, in Taiwan who were followed for an average of more than three years. The findings will appear in the Journal of Clinical Endocrinology & Metabolism. "Our study found that metabolic syndrome predicts both the prevalence and incidence of chronic kidney disease in people aged 65 years or older," the lead ... Read more

Related support groups: Insulin Resistance

Heart Failure, Diabetes Might Be Linked by Protein

Posted 5 Jan 2012 by Drugs.com

THURSDAY, Jan. 5 – Researchers may have pinpointed how heart disease can lead to diabetes, a finding that could lead to new preventive treatments. The team at Chiba University in Japan found that the stress of heart failure activates a protein called p53, resulting in inflammation in fat tissue, systemic insulin resistance and worsening heart function. This domino effect is outlined in a study in the January issue of the journal Cell Metabolism. "Our findings clarify the reasons why the incidence of heart failure is high among diabetic patients, why the prevalence of insulin resistance is increased in heart failure patients and why treatment of insulin resistance improves the prognosis of heart failure patients," study author Tohru Minamino said in a journal news release. Previous research by the author has shown that build-up of p53 in the heart – from stress or age – promotes heart ... Read more

Experimental Drug Slims Obese Monkeys

Posted 9 Nov 2011 by Drugs.com

WEDNESDAY, Nov. 9 – An experimental drug that targets and kills fat cells in the blood appears to help obese rhesus monkeys lose weight, a new study suggests. In the future, this approach may help obese humans lose weight, according to the University of Texas M.D. Anderson Cancer Center researchers. "Targeting blood vessels of white fat tissue is a novel conceptual approach against obesity," said study author Dr. Wadih Arap, the Stringer Professor of Medicine and Experimental Diagnostic Imaging at M.D. Anderson. "Adipotide is a new drug candidate against obesity to be translated into potential clinical applications in humans." The report was published in the Nov. 9 issue of Science Translational Medicine. The usual way drugs work to counter obesity is either by suppressing appetite or by increasing metabolism to try to burn calories faster, the investigators noted. However, this new ... Read more

Related support groups: Obesity, Diabetes, Type 2, Insulin Resistance

Health Tip: Metabolic Syndrome Raises Chance of Cardiovascular Disease

Posted 12 Oct 2011 by Drugs.com

-- Metabolic syndrome, a host of risk factors often thought of as a precursor to diabetes, also doubles a person's risk of developing cardiovascular disease, the U.S. National Heart Lung and Blood Institute says. The agency says if you have three or more of these risk factors, you probably have metabolic syndrome: A large waistline (too much abdominal fat). High levels of triglycerides, fats found in the blood. Low levels of HDL ("good") cholesterol. High blood sugar. High blood pressure. Read more

Related support groups: Insulin Resistance, Prevention of Cardiovascular Disease

Chocolate Could Be Sweet Defense Against Stroke

Posted 10 Oct 2011 by Drugs.com

MONDAY, Oct. 10 – In the latest research to tout the cardiovascular benefits of an already beloved food, Swedish scientists report that eating chocolate seems to lower a woman's risk of stroke. The study found that women who had the highest consumption of chocolate – about two candy bars a week – had a 20 percent reduced risk of stroke. "Cocoa contains flavonoids, which have antioxidant properties and can suppress oxidation of low-density lipoprotein ['bad' cholesterol] which can cause cardiovascular disease [including stroke]," explained study author Susanna Larsson, an associate professor in the division of nutritional epidemiology at the Karolinska Institute in Stockholm. Chocolate's benefits don't end there, Larsson said, adding that dark chocolate consumption has also been found to reduce blood pressure, lower insulin resistance and help keep your blood from forming dangerous ... Read more

Certain Risk Factors Could Spur Heart Failure in Normal-Weight People

Posted 14 Sep 2011 by Drugs.com

WEDNESDAY, Sept. 14 – Normal-weight patients diagnosed with a cluster of factors known as the "metabolic syndrome" could face a higher risk for heart failure than even obese patients without such factors, new research suggests. Metabolic syndrome is characterized by a group of symptoms – increased blood pressure, higher-than-normal insulin levels, excess body fat around the waist, high triglycerides and/or abnormal cholesterol levels – that raise the risk of stroke, heart disease and diabetes. A healthy metabolic profile, in turn, is marked by the absence of those symptoms, suggesting the major organs systems are in balance. The new study suggests that being obese is not as much of a threat for heart failure as are those specific factors that typically contribute to a diagnosis of metabolic syndrome. These include having an "apple shape" (carrying extra weight around the middle and ... Read more

Related support groups: Heart Failure, Congestive Heart Failure, Insulin Resistance

Metabolic Syndrome Linked to Kidney Disease

Posted 19 Aug 2011 by Drugs.com

FRIDAY, Aug. 19 – People with metabolic syndrome are at increased risk for kidney disease, a new study suggests. Metabolic syndrome refers to the presence of three or more of the following health threats: high blood pressure, high blood sugar, low good cholesterol, excess fat in the waist/abdomen, and elevated levels of fatty acids. It was known that people with metabolic syndrome are at increased risk for diabetes, heart disease, stroke and premature death. This study adds kidney disease to that list. Researchers analyzed data from more than 30,000 people in 11 studies that examined the relationship between metabolic syndrome and kidney disease. The review revealed that people with metabolic syndrome have a 55 percent increased risk of kidney problems, especially reduced kidney function, which is indicative of kidney disease. The researchers also found that individual characteristics ... Read more

Related support groups: Insulin Resistance, Chronic Kidney Disease

Obesity Greater Risk for Fatty Liver Than Alcohol, Study Finds

Posted 2 Jun 2011 by Drugs.com

THURSDAY, June 2 – Obesity and insulin resistance constitute a greater risk for fatty liver disease than moderate alcohol consumption, according to a new study that found drinking modest amounts of red wine posed no greater risk for developing the condition. For their study, published online May 23 in Annals of Medicine, Swedish researchers instructed 44 people to either abstain from alcohol or drink one (women) or two (men) glasses of red wine a day for three months. At the beginning and end of the three months, the investigators collected blood samples and conducted MRIs to measure the fatty content of participants' livers. "It turned out that the amount of fat in the liver was linked with obesity and insulin resistance and was almost not at all affected by the red wine. Specifically, after three months, none of the wine drinkers had developed fatty liver or elevated liver ... Read more

Related support groups: Obesity, Insulin Resistance, Nonalcoholic Fatty Liver Disease

Mediterranean Diet Reduces Risk of Metabolic Syndrome

Posted 8 Mar 2011 by Drugs.com

TUESDAY, March 8 – The Mediterranean diet, long known to be heart-healthy, also reduces the risk of metabolic syndrome, a cluster of risk factors that boost the risk of heart disease, stroke and diabetes, according to a new review. Researchers from Greece and Italy reviewed the results of 50 published studies with a total of more than 500,000 participants as part of a meta-analysis – a statistical analysis of the findings of similar studies – on the Mediterranean diet. Among their findings: the natural foods-based diet is associated with a lower risk of hikes in blood pressure, blood sugar and triglycerides, as well as a reduced risk of a drop in good cholesterol – all of which are risk factors in metabolic syndrome. "It is one of the first times in the literature, maybe the first, that someone looks through a meta-analysis at the cardiovascular disease risk factors and not only the ... Read more

Related support groups: Insulin Resistance

Insulin Resistance Might Raise Risk of Stroke

Posted 11 Oct 2010 by Drugs.com

MONDAY, Oct. 11 – People with insulin resistance may be at higher risk for stroke even if they don't have full-blown diabetes, a new study indicates. Paying close attention to people who show signs of insulin resistance – a reduction in the ability of the hormone insulin to clear glucose from the bloodstream – may be helpful in preventing stroke, the researchers noted. Treating it may also reduce the risk of having an ischemic stroke, which occurs when blood supply to the brain is blocked. "We showed that the increased risk of stroke among people with insulin resistance is three times higher than among those that don't have insulin resistance and are non-diabetic," said Dr. Tatjana Rundek, lead author of the study in the October issue of the Archives of Neurology. "That's telling us that there is a group of people that may be targeted for more treatment intervention in order to ... Read more

Related support groups: Insulin Resistance

Fat Cells Grow Differently in Belly Vs. Bottom

Posted 6 Oct 2010 by Drugs.com

WEDNESDAY, Oct. 6 – Differences in the way body fat grows may explain why increased belly fat appears to boost the risk for certain diseases while extra pounds on the thighs and other parts of the lower body decrease the risk, a new study suggests. The study included 28 volunteers who were allowed to eat almost anything they wanted – including ice cream, candy bars and high-calorie drinks – for eight weeks. On average, the participants put on 5.5 pounds of upper body fat and 3.3 pounds of lower body fat, Mayo Clinic researchers reported in this week's online issue of the Proceedings of the National Academy of Sciences. "The cellular mechanisms are different," lead author and endocrinologist Dr. Michael Jensen said in a Mayo news release. "The accumulation of abdominal fat happens largely by individual cells expanding in size, while with fat gain in the femoral or lower body, it's the ... Read more

Related support groups: Insulin Resistance

Metabolic Syndrome Doubles Heart Risk, Analysis Shows

Posted 20 Sep 2010 by Drugs.com

MONDAY, Sept. 20 – A group of health conditions collectively known as metabolic syndrome may pose an even greater danger to the heart than previously recognized, new study findings suggest. The combination of metabolic syndrome risk factors – including obesity, high blood pressure, high cholesterol and insulin resistance – increases the risk of developing heart disease and diabetes. And about 25 percent of American adults have metabolic syndrome, according to the U.S. National Heart, Lung, and Blood Institute. In the new analysis, researchers examined more than 70 recent studies that included a total of nearly one million patients. The investigators found that people with metabolic syndrome are up to 2.5 times more likely to die of heart-related causes and to have heart disease, a heart attack or stroke, compared to people without the syndrome. In addition, metabolic syndrome ... Read more

Related support groups: Insulin Resistance

Link Between Diabetes, Alzheimer's Disease Strengthened

Posted 25 Aug 2010 by Drugs.com

WEDNESDAY, Aug. 25 – Two of the most common and dreaded illnesses in America may share a connection, with new research suggesting that having insulin resistance or type 2 diabetes raises your risk of developing the brain plaques associated with Alzheimer's disease. After adjusting for other risk factors, the Japanese study found that people with the highest levels of fasting insulin had nearly six times the odds of having plaque deposits between nerves in the brain, compared to people with the lowest levels of fasting insulin. Those with the highest scores on a measure of insulin resistance (where cells become less able to use insulin effectively) had about five times the odds of having brain plaques vs. those with the lowest scores on the insulin-resistance test, the study found. In fact, "the risk of plaque-type Alzheimer's disease pathology increases in a linear relationship with ... Read more

Related support groups: Diabetes, Type 2, Alzheimer's Disease, Insulin Resistance

Adding Fish Oil to Low-Fat/High-Carb Diet May Improve Cholesterol

Posted 22 Aug 2010 by Drugs.com

FRIDAY, Aug. 20 – For people with the metabolic syndrome – a cluster of risk factors such as obesity, high blood pressure, high levels of blood fats or triglycerides and high blood sugar – adding a little fish oil to a diet low in saturated fats and high in complex carbohydrates might be just the ticket, a new study suggests. "When you add omega-3 to a high carbohydrate, low-fat diet, you can prevent the long-term adverse effect that a high-carbohydrate diet induces on [blood fats]," said study author Dr. Jose Lopez-Miranda, a professor of medicine at the Reina Sofia University Hospital and the University of Cordoba, Spain. The study is published in the September issue of the Journal of Nutrition. Lopez-Miranda and his team looked at 117 people with metabolic syndrome, which raises the risk of heart disease and stroke. They assigned them to one of four diets for 12 weeks. The diets ... Read more

Vitamin D Deficiency Linked to Diabetes, Metabolic Syndrome in Studies

Posted 20 Jun 2010 by Drugs.com

SATURDAY, June 19 – A pair of new studies has uncovered evidence that low levels of vitamin D could lead to poor blood sugar control among diabetics and increase the risk of developing metabolic syndrome among seniors. Both findings are slated to be presented Saturday at the Endocrine Society's annual meeting in San Diego. In one study, researchers at the Johns Hopkins University School of Medicine in Baltimore reviewed the medical charts of 124 type 2 diabetes patients who sought specialty care at an endocrine outpatient facility between 2003 and 2008. More than 90 percent of the patients, who ranged in age from 36 to 89, had either vitamin D deficiency or insufficiency, the authors found, despite the fact that they all had had routine primary care visits before their specialty visit. Just about 6 percent of the patients were taking a vitamin D supplement at the time of their visit, ... Read more

Related support groups: Insulin Resistance, Vitamin D Deficiency, Vitamin D Insufficiency

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