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Osteoporosis Drugs Work, But Review Finds No Clear Winner

Posted 8 Sep 2014 by Drugs.com

MONDAY, Sept. 8, 2014 – Many osteoporosis drugs cut women's risk of suffering a bone fracture, though it's not clear whether any one medication works better than others, a new research review finds. Reporting Sept. 8 in Annals of Internal Medicine, researchers said that for women with the bone-thinning disease osteoporosis, various drugs cut the risk of a spine fracture by 40 to 60 percent, compared to a placebo. When it comes to other bone breaks, including hip fractures, the drugs lower the risk by 20 to 40 percent, the study said. The beneficial drugs included bisphosphonates, sold under brand names such as Actonel (risedronate), Boniva (ibandronate) and Fosamax (alendronate), and the injection drugs denosumab (Prolia) and teriparatide (Forteo). Meanwhile, raloxifene (Evista) – a daily pill that has estrogen-like effects on bones – seems to cut the risk of spine fractures only, ... Read more

Related support groups: Osteoporosis, Fosamax, Forteo, Boniva, Alendronate, Reclast, Evista, Prolia, Actonel, Prevention of Osteoporosis, Fracture, bone, Zometa, Aclasta, Xgeva, Ibandronate, Atelvia, Zoledronic Acid, Risedronate, Raloxifene, Denosumab

More Evidence Ties Some Bone-Building Drugs to Rare Fractures

Posted 4 Sep 2014 by Drugs.com

THURSDAY, Sept. 4, 2014 – Taking osteoporosis drugs called bisphosphonates to help prevent fractures may carry a slight risk for unusual breaks in the thigh bone, Swedish researchers report. For those who took bisphosphonates for four to five years, the so-called "relative risk" was 100 times higher than among people who didn't use the medications. But the researchers explained that the absolute risk of having such a fracture was small, and would affect only one in 1,000 people. "If you have osteoporosis, the benefit of bisphosphonates outweighs the risk during the first years of treatment. But if you don't have osteoporosis, but only a moderate decrease in bone density, the benefit is likely to be smaller than the risk," said lead researcher Dr. Per Aspenberg, a professor of orthopaedic surgery at Linkoping University in Sweden. However, U.S. experts said bisphosphonates still have a ... Read more

Related support groups: Osteoporosis, Fosamax, Boniva, Alendronate, Reclast, Actonel, Prevention of Osteoporosis, Fracture, bone, Zometa, Aclasta, Ibandronate, Zoledronic Acid, Atelvia, Risedronate, Pamidronate, Aredia, Skelid, Etidronate, Fosamax Plus D, Actonel with Calcium

Bone Drugs Don't Lower Breast Cancer Risk After All, Study Finds

Posted 11 Aug 2014 by Drugs.com

MONDAY, Aug. 11 – Drugs known as bisphosphonates, commonly prescribed to treat the bone-weakening disease osteoporosis, don't appear to reduce the risk of breast cancer as previously thought, new research finds. "We found that postmenopausal women who took a bisphosphonate for three or four years did not have a decreased risk in breast cancer," said study author Trisha Hue, an epidemiologist at the University of California, San Francisco. When prior observational studies noted links between the drugs' use and lower breast cancer risk in, experts assumed the drugs deserved the credit. However, based on the new findings, Hue suspects that low estrogen levels may have been the risk-reducer. "Women who get bisphosphonates have a low bone mass density," she said. "If you have low bone mass density, you probably have low estrogen." This is because the hormone, which is depleted after ... Read more

Related support groups: Breast Cancer, Osteoporosis, Fosamax, Boniva, Alendronate, Reclast, Actonel, Prevention of Osteoporosis, Zometa, Aclasta, Ibandronate, Atelvia, Zoledronic Acid, Risedronate, Pamidronate, Aredia, Skelid, Etidronate, Fosamax Plus D, Actonel with Calcium

Newer Bone Drug Better for Advanced Breast Cancer Patients: Study

Posted 14 Aug 2012 by Drugs.com

TUESDAY, Aug. 14 – The relatively new drug denosumab (Xgeva) reduces bone complications of advanced breast cancer more effectively than another osteoporosis drug, zoledronic acid (Zometa), according to new research. Zoledronic acid belongs to a class of drugs known as bisphosphonates, which help delay bone complications such as fractures, spinal cord compression and bone pain. But zoledronic acid has been linked with kidney toxicity and other reactions. Denosumab, a newer drug called a monoclonal antibody, is superior to zoledronic acid in reducing skeletal problems and better tolerated, the study found. "It's more effective at preventing bone destruction caused by breast cancer that has spread to the bone," said Dr. Alison Stopeck, associate professor of medicine at the University of Arizona, Tucson, and an investigator on the study, which was published Aug. 14 in the journal Clinical ... Read more

Related support groups: Fosamax, Boniva, Alendronate, Reclast, Prolia, Actonel, Zometa, Aclasta, Xgeva, Ibandronate, Atelvia, Zoledronic Acid, Risedronate, Denosumab, Pamidronate, Aredia, Skelid, Etidronate, Fosamax Plus D, Actonel with Calcium

More Research Points to Long-Term Ills With Bone Drugs

Posted 21 May 2012 by Drugs.com

MONDAY, May 21 – Adding more weight to concerns about possible long-term dangers of osteoporosis drugs, a new study finds that people who take the drugs, known as bisphosphonates, may be at increased risk for atypical fractures of the thigh bone (femur). Osteoporosis is a bone-thinning disease that is common in older women. An atypical femoral fracture is an unusual type of break that often occurs spontaneously, without any major leg injury. In the new study, Swiss researchers looked at 477 patients, aged 50 and older, who were hospitalized with a femoral fracture. Of those patients, 39 had atypical fractures and 438 had a classic fracture (a more common fracture with a typical pattern). These groups were compared with 200 people without femoral fractures. The findings were published online May 21 in the journal Archives of Internal Medicine. The investigators found that 82 percent of ... Read more

Related support groups: Osteoporosis, Fosamax, Boniva, Alendronate, Reclast, Actonel, Prevention of Osteoporosis, Fracture, bone, Zometa, Aclasta, Ibandronate, Zoledronic Acid, Atelvia, Risedronate, Pamidronate, Aredia, Skelid, Etidronate, Fosamax Plus D, Actonel with Calcium

Osteoporosis Drugs May Lead to Eye Trouble: Study

Posted 2 Apr 2012 by Drugs.com

MONDAY, April 2 – First-time users of osteoporosis drugs called oral bisphosphonates may be at increased risk for serious inflammatory eye disease, a new study contends. Oral bisphosphonates, such as Fosamax and Actonel, are the most commonly prescribed class of drugs to prevent or slow osteoporosis, a disease that causes very weak bones. Previous studies have linked the drugs to problems such as unusual fractures, irregular heartbeat and esophageal and colon cancer. In addition, some case reports have shown an association between the drugs and inflammatory eye diseases – anterior uveitis and scleritis – that can cause serious vision impairment. In this new study, Canadian researchers compared nearly 11,000 first-time users of oral bisphosphonates and more than 920,000 non-users. First-time users had incidence rates of 29 per 10,000 person-years for uveitis and 63 per 10,000 ... Read more

Related support groups: Osteoporosis, Fosamax, Boniva, Alendronate, Reclast, Actonel, Prevention of Osteoporosis, Zometa, Aclasta, Ibandronate, Zoledronic Acid, Atelvia, Risedronate, Pamidronate, Aredia, Etidronate, Skelid, Fosamax Plus D, Actonel with Calcium, Didronel IV

Generic Boniva Approved for Osteoporosis

Posted 19 Mar 2012 by Drugs.com

MONDAY, March 19 – The first generic versions of the once-monthly osteoporosis drug Boniva (ibandronate) have been approved by the U.S. Food and Drug Administration. Osteoporosis, characterized by a thinning of the bones, is the most common type of bone disease, the agency said in a news release Monday. More common in postmenopausal women, it increases the risk of fracture, especially of the hip, spine and wrist. More than 40 million people in the United States have the disease or are at significant risk for it, the FDA said. Approvals to produce generic Boniva have been granted to: Apotex Inc., Orchid Healthcare and Mylan Pharmaceuticals. Generic drugs are medically equivalent to the brand-name versions and are subject to the same quality standards, the agency said. Generic Boniva will be accompanied by a guide that explains potential serious reactions, including esophagus problems; ... Read more

Related support groups: Osteoporosis, Boniva, Prevention of Osteoporosis, Ibandronate, Bondronat

Stopping Bone Drug Cuts Risk of Second Thigh Fracture: Study

Posted 9 Feb 2012 by Drugs.com

THURSDAY, Feb. 9 – People who suffer a rare type of fracture of the thigh bone while taking bone-building drugs known as bisphosphonates can cut the risk of a second fracture by discontinuing the medication, a new study says. Bisphosphonates such as Fosamax, Boniva and Actonel are often prescribed for postmenopausal women or people taking steroid medications to prevent or slow the bone-weakening disease osteoporosis. But the drugs have been linked to a small risk of unusual fractures of the femur. One out of 1,000 taking the drugs for six years will suffer such a fracture, the researchers said. For the study, the researchers examined femur fracture records for patients older than 45 from a large California insurer. Over two years, they found 126 patients reportedly taking bisphosphonates suffered an atypical femur fracture. Of those patients, 41.2 percent who continued taking the drugs ... Read more

Related support groups: Fosamax, Boniva, Alendronate, Reclast, Actonel, Zometa, Aclasta, Ibandronate, Atelvia, Zoledronic Acid, Risedronate, Pamidronate, Aredia, Skelid, Etidronate, Fosamax Plus D, Actonel with Calcium, Tiludronate, Didronel IV, Calcium Carbonate/Risedronate

Osteoporosis Drugs' Safety Subject of FDA Panel

Posted 9 Sep 2011 by Drugs.com

FRIDAY, Sept. 9 – Experts convened by the U.S. Food and Drug Administration were to meet Friday to discuss problems linked to long-term use of bone-building drugs such as Fosamax, Actonel, Boniva and Reclast. These drugs, known as bisphosphonates, are taken to prevent fractures related to postmenopausal osteoporosis. But researchers have linked long-term use with a small risk of unusual fractures of the thigh bone, death of the jawbone (osteonecrosis of the jaw) and possibly esophageal cancer. Members of two FDA advisory committees are expected to weigh the drugs' risks and benefits and possibly come up with new recommendations regarding their use. According to the FDA, in 2009 more than 5 million prescriptions were filled for bisphosphonates, which inhibit bone loss. Dr. Elizabeth Shane, past president of the American Society for Bone and Mineral Research, who is scheduled to testify ... Read more

Related support groups: Fosamax, Boniva, Alendronate, Reclast, Actonel, Zometa, Aclasta, Ibandronate, Zoledronic Acid, Atelvia, Risedronate, Pamidronate, Aredia, Etidronate, Skelid, Fosamax Plus D, Actonel with Calcium, Alendronate/Cholecalciferol, Didronel IV, Bondronat

FDA Medwatch Alert: Oral Osteoporosis Drugs (bisphosphonates): Drug Safety Communication - Potential Increased Risk of Esophageal Cancer

Posted 21 Jul 2011 by Drugs.com

Includes: Fosamax (alendronate), Actonel (risedronate), Boniva (ibandronate), Atelvia (risedronate delayed release), Didronel (etidronate), and Skelid (tiludronate) ISSUE: FDA notified healthcare professionals and patients about its ongoing review of data from published studies to evaluate whether use of oral bisphosphonate drugs is associated with an increased risk of cancer of the esophagus. FDA has not concluded that taking an oral bisphosphonate drug increases the risk of esophageal cancer. There are insufficient data to recommend endoscopic screening of asymptomatic patients. FDA will continue to evaluate all available data supporting the safety and effectiveness of bisphosphonate drugs and will update the public when more information becomes available. BACKGROUND: Oral bisphosphonates are commonly used for the prevention and treatment of osteoporosis as well as to treat other bone ... Read more

Related support groups: Fosamax, Boniva, Alendronate, Reclast, Actonel, Zometa, Aclasta, Ibandronate, Zoledronic Acid, Atelvia, Risedronate, Pamidronate, Aredia, Etidronate, Skelid, Fosamax Plus D, Actonel with Calcium, Alendronate/Cholecalciferol, Didronel IV, Bondronat

Study Finds Slight Risk of Rare Fractures From Bone Drugs

Posted 4 May 2011 by Drugs.com

WEDNESDAY, May 4 – Bone-building drugs called bisphosphonates have been linked to rare fractures of the thigh bone, but Swedish researchers report that the risk is so small that most patients needn't worry. Bisphosphonates include the widely used medications Fosamax, Boniva and Actonel, which are typically taken by people with osteoporosis to increase bone strength and prevent fractures. "Osteoporotic fractures are quite common and bisphosphonates reduce this risk a lot, but the price you have to pay for that is a small risk in getting a so-called fatigue fracture," said lead researcher Dr. Per Aspenberg, a professor of orthopedics at Linkoping University. "These findings must be seen in the context of the debate that has been going on for the past year," he added. "Our data argues very strongly for a causal relationship." However, the risk of getting an atypical fracture is similar to ... Read more

Related support groups: Fosamax, Boniva, Alendronate, Reclast, Actonel, Zometa, Aclasta, Ibandronate, Zoledronic Acid, Atelvia, Risedronate, Pamidronate, Aredia, Etidronate, Skelid, Fosamax Plus D, Actonel with Calcium, Alendronate/Cholecalciferol, Didronel IV, Bondronat

Popular Bone Drugs Linked to Reduced Colon Cancer Risk

Posted 15 Feb 2011 by Drugs.com

TUESDAY, Feb. 15 – People who take drugs called bisphosphonates to prevent bone loss may also reduce their risk of developing colorectal cancer by almost 60 percent compared to those not on the drugs, a new study suggests. Bisphosphonates include such common drugs as Fosamax (alendronate), Boniva (ibandronate), Actonel (risedronate) and Reclast (zoledronic acid). These drugs work by increasing bone thickness, thereby reducing the risk of fractures, the researchers said. In prior studies, bisphosphonates have already been shown to be associated with a reduced odds for breast cancer. "These [new] findings are meaningful because they point to a possible protective effect of this class of drugs being relevant to prevention of many different cancers," said lead researcher Dr. Gad Rennert, from the Technion-Israel Institute of Technology Faculty of Medicine and chairman of the department of ... Read more

Related support groups: Fosamax, Boniva, Alendronate, Reclast, Actonel, Zometa, Aclasta, Ibandronate, Zoledronic Acid, Atelvia, Risedronate, Pamidronate, Aredia, Etidronate, Skelid, Fosamax Plus D, Actonel with Calcium, Alendronate/Cholecalciferol, Didronel IV, Bondronat

Study Suggests Osteoporosis Drug Might Treat Loss of Bone in Jaw

Posted 17 Oct 2010 by Drugs.com

SATURDAY, Oct. 15 – People suffering from a disfiguring loss of bone in the jaw may find help in the form of a long-used osteoporosis drug, two new studies suggest. Besides being linked to chronic, severe gum disease, this type of bone loss has also been connected in rare cases to the use of bisphosphonates, a different class of osteoporosis drugs. But the two papers in the Oct. 16 online issue of the New England Journal of Medicine report success with teriparatide (Forteo) in rebuilding bone. One report describes the case of an 88-year-old woman who had been taking the bisphosphonate alendronate (Fosamax) since suffering a hip fracture 10 years earlier. She had also been taking the corticosteroid prednisone for two decades. Experts have already noticed an uptick in the incidence of this rare but devastating condition in patients using bisphosphonates. According to an editorial ... Read more

Related support groups: Fosamax, Forteo, Boniva, Alendronate, Reclast, Actonel, Zometa, Aclasta, Periodontitis, Ibandronate, Zoledronic Acid, Risedronate, Pamidronate, Aredia, Teriparatide, Skelid, Etidronate, Fosamax Plus D, Actonel with Calcium, Calcium Carbonate/Risedronate

Cancer-Fighting Bone Drugs Might Raise Stroke Risk

Posted 12 Oct 2010 by Drugs.com

TUESDAY, Oct. 12 – A new study finds that cancer patients treated with bisphosphonate drugs such as Aredia or Zometa to reduce or delay bone complications from cancer may be at higher risk for the irregular heartbeat known as atrial fibrillation and for a related event, stroke. In atrial fibrillation, the upper chambers of the heart beat chaotically, causing blood to pool and increasing the potential of clots, stroke, heart failure and death. However, the bump up in risk with bisphosphonates was "relatively modest," said Dr. James Goodwin, senior author of a paper appearing online Oct. 12 in the Journal of Clinical Oncology. At relatively low doses, bisphosphonates have been widely used for about three decades to treat osteoporosis, mainly in older women. Then, "in the 1990s, it was discovered that they had a rather miraculous effect in terms of either treating or preventing metastases ... Read more

Related support groups: Fosamax, Boniva, Alendronate, Reclast, Actonel, Zometa, Aclasta, Ibandronate, Zoledronic Acid, Risedronate, Pamidronate, Aredia, Etidronate, Skelid, Fosamax Plus D, Actonel with Calcium, Alendronate/Cholecalciferol, Didronel IV, Bondronat, Tiludronate

Expert Panel Links Popular Bone Drugs to Rare Fracture

Posted 14 Sep 2010 by Drugs.com

TUESDAY, Sept. 14 – An expert panel concludes that bone-strengthening bisphosphonate drugs such as Actonel, Boniva and Fosamax can actually raise risks for a rare type of fracture of the thighbone. The panel is urging the U.S. Food and Drug Administration – which has been awaiting the report – to add a special warning to that effect on the drugs' labeling. "Bisphosphonates may be related to atypical femur fractures," said Dr. Elizabeth Shane, a professor of medicine at Columbia University's College of Physicians and Surgeons in New York City. She is the lead author of the report, which was compiled by a special task force at the American Society for Bone and Mineral Research. "These fractures are very unusual," Shane added. "But we are still concerned that patients could still have these fractures. There may well be a link between these fractures and bisphosphonates." The FDA has ... Read more

Related support groups: Fosamax, Boniva, Alendronate, Reclast, Actonel, Zometa, Aclasta, Ibandronate, Zoledronic Acid, Risedronate, Pamidronate, Aredia, Etidronate, Skelid, Fosamax Plus D, Actonel with Calcium, Alendronate/Cholecalciferol, Didronel IV, Bondronat, Tiludronate

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