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Related terms: Orthostatic Hypotension
Posted 19 Mar 2012 by Drugs.com
MONDAY, March 19 – If your blood pressure drops suddenly when you stand up, leaving you feeling lightheaded or woozy, you may be at greater risk for developing heart failure, a new study suggests. This condition is known as orthostatic hypotension. According to the study, people with orthostatic hypotension were 54 percent more likely to develop heart failure than their counterparts who did not develop low blood pressure upon standing. This risk was reduced to 34 percent when the researchers teased out those who also had high blood pressure. "Multiple risk factors can increase a person's risk for developing heart failure, including high blood pressure, coronary heart disease and diabetes," explained study author Dr. Christine DeLong Jones, a preventive medicine resident at the University of North Carolina at Chapel Hill. "Orthostatic hypotension may also increase this risk." Heart ... Read more
Posted 26 Sep 2011 by Drugs.com
From Philadelphia Inquirer (PA) (September 25, 2011) Sept. 25--The normal tug-of-war between a pharmaceutical company and the U.S. Food and Drug Administration over approval for a drug has been turned on its side with midodrine, a medicine that helps about 100,000 patients a year avoid the potential dangers of low blood pressure. Shire Pharmaceuticals Inc., with U.S. headquarters in Wayne, no longer makes the drug, but it wants the FDA to give final approval of midodrine to lift a regulatory cloud. Barring that, it wants the FDA to approve Shire's plan for new trials or hold a hearing that might kill the drug. Though it has been on the market for 15 years under a temporary approval, midodrine never passed its final clinical trials. Now, the FDA is in a bind no matter how it acts, including doing nothing. "It is a Catch-22," said cardiologist John Harold of the Cedars-Sinai Heart ... Read more