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More Sex, Better Testosterone Levels?

Posted 16 days ago by Drugs.com

FRIDAY, March 13, 2015 – Experts have long assumed that as a man's testosterone level declines, so does his sex life. But a new study suggests the reverse may be true. "Most people in or out of medicine assume that a lowered serum testosterone may cause reduced sexual activity. But our study questions, if not fully refutes, that assumption and suggests it is the other way around," said Dr. David Handelsman, a researcher at the University of Sydney, in New South Wales, Australia. And skyrocketing sales of testosterone supplements are being fueled by that popular assumption, even though it might not be correct, Handelsman added. But one doctor not involved with the study questioned the finding, noting that other lifestyle factors might be affecting testosterone levels as men age. And the study wasn't designed to take those factors into account. In the study, the researchers evaluated ... Read more

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Early Studies See No Heart Risk From Testosterone Therapy

Posted 4 Mar 2015 by Drugs.com

WEDNESDAY, March 4, 2015 – Testosterone therapy doesn't seem to increase a man's risk of heart attack or stroke, a pair of new studies suggests. "Testosterone therapy in any form – gel, pills or injections – does not appear to cause adverse cardiovascular effects," said Dr. Pawan Patel, lead author of one of the studies and an academic physician at Regions Hospital in St. Paul, Minn. The studies are to be presented next week at the American College of Cardiology (ACC) annual meeting, in San Diego. Research presented at medical meetings is typically viewed as preliminary until published in a peer-reviewed journal. The two studies were released a day after the U.S. Food and Drug Administration issued a warning about the overuse of testosterone-boosting drugs by aging baby boomers trying to use hormone therapy to turn back the clock. The FDA will require all prescription testosterone ... Read more

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Testosterone May Not Deliver Victory for Athletes, Study Found

Posted 1 Dec 2014 by Drugs.com

MONDAY, Dec. 1, 2014 – Higher levels of testosterone during competition do not improve athletes' chances of victory, a new study finds. "Many people in the scientific literature and in popular culture link testosterone increases to winning," Kathleen Casto, a graduate student in psychology at Emory University in Atlanta, said in a university news release. "In this study, however, we found an increase in testosterone during a race regardless of the athletes' finish time. In fact, one of the runners with the highest increases in testosterone finished with one of the slowest times," she said. Casto and colleagues measured testosterone levels in the saliva of varsity men and women cross-country runners before a race, after they warmed up and at the end of the race. They also checked levels of cortisol, a hormone related to stress. Testosterone levels increased during warm-up, but cortisol ... Read more

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Testosterone Plays Minor Role in Older Women's Sex Lives, Study Finds

Posted 21 Nov 2014 by Drugs.com

THURSDAY, Nov. 20, 2014 – While levels of testosterone and other reproductive hormones have some effect on menopausal women's sex lives, their emotional health and quality of their relationships have a stronger influence, according to a new study. Testosterone is the main sex hormone in men. But, women's ovaries also naturally produce small amounts of the hormone, the researchers noted. The researchers analyzed data from more than 3,300 American women taking part in a long-term study of women's health. They found that women with higher levels of testosterone and another reproductive hormone called dehydroepiandrosterone sulfate (DHEAS) felt sexual desire and masturbated more often than those with low levels of the hormones. However, the links between hormone levels and sexual function were subtle, according to Dr. John Randolph Jr., of the University of Michigan Medical School. ... Read more

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Testosterone Plays Minor Role in Older Women's Sex Lives, Study Finds

Posted 21 Nov 2014 by Drugs.com

THURSDAY, Nov. 20, 2014 – While levels of testosterone and other reproductive hormones have some effect on menopausal women's sex lives, their emotional health and quality of their relationships have a stronger influence, according to a new study. Testosterone is the main sex hormone in men. But, women's ovaries also naturally produce small amounts of the hormone, the researchers noted. The researchers analyzed data from more than 3,300 American women taking part in a long-term study of women's health. They found that women with higher levels of testosterone and another reproductive hormone called dehydroepiandrosterone sulfate (DHEAS) felt sexual desire and masturbated more often than those with low levels of the hormones. However, the links between hormone levels and sexual function were subtle, according to Dr. John Randolph Jr., of the University of Michigan Medical School. ... Read more

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No Testosterone Therapy for Healthy Women, New Guidelines State

Posted 3 Oct 2014 by Drugs.com

FRIDAY, Oct. 3, 2014 – Healthy women should not be diagnosed with testosterone deficiency and should not be prescribed testosterone therapy, a new guideline from the Endocrine Society states. "Although limited research suggests testosterone therapy in menopausal women may be linked to improved sexual function, there are too many unanswered questions to justify prescribing testosterone therapy to otherwise healthy women," guideline task force chair Dr. Margaret Wierman, of the University of Colorado, said in a society news release. "When we reviewed past studies, we found many women who had low testosterone levels measured by older or new techniques did not exhibit any signs or symptoms of concern. As a result, physicians cannot make a diagnosis of androgen deficiency in women," said Wierman, who is vice president of clinical science at the endocrine society. The only time a woman might ... Read more

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FDA Panel: Limit Testosterone Drug Use

Posted 18 Sep 2014 by Drugs.com

THURSDAY, Sept. 18, 2014 – There is little evidence that testosterone replacement therapy effectively treats normally sagging levels of the hormone in aging American males, a U.S. Food and Drug Administration advisory panel said Wednesday. The panel, from two key FDA committees, overwhelmingly voted, 20-1, to tighten use of the popular drugs and require drug makers to conduct tests assessing the drugs' risk of heart attack and stroke, according to Bloomberg News. "The whole idea is to try to rein in the inappropriate advertising and use of these drugs," Dr. Michael Domanski, a panel member who is director of heart failure research at Mount Sinai School of Medicine in New York City, told The New York Times. The FDA is not required to follow the recommendations of its expert panels, but usually does. Along with sharply curtailing how many men might be prescribed testosterone supplements, ... Read more

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FDA to Probe Testosterone Therapy Claims, Safety

Posted 16 Sep 2014 by Drugs.com

TUESDAY, Sept. 16, 2014 – The U.S. Food and Drug Administration is focusing on the "Low T" fad, questioning whether the boom in testosterone replacement therapy is helping or harming the health of aging American males. At a joint meeting scheduled for Sept. 17-18, two key FDA committees will discuss whether doctors are prescribing testosterone therapy for too many men, and if misuse of the male hormone increases the risk of stroke and heart attack. The Baby Boom generation has turned to testosterone replacement therapy in response to the sagging muscles, lower energy levels and sexual problems that can accompany natural aging, the FDA noted in a review provided to committee members in advance of the meeting. "There's a large group of men out there who are getting older, and they are looking for ways to evade the consequences of aging," said Dr. Bradley Anawalt, an endocrinologist from ... Read more

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Latest Study Finds No Link Between Testosterone Supplements, Heart Attack

Posted 2 Jul 2014 by Drugs.com

WEDNESDAY, July 2, 2014 – Although recent research has linked testosterone therapy with a higher risk for heart attack and stroke, a new study involving more than 25,000 older men suggests otherwise. The study, funded by the U.S. National Institutes of Health, may help ease some fears about testosterone therapy for patients and their families, the study authors said. "Our investigation was motivated by a growing concern, in the U.S. and internationally, that testosterone therapy increases men's risk for cardiovascular disease, specifically heart attack and stroke," lead researcher Jacques Baillargeon, an associate professor of epidemiology at the University of Texas Medical Branch at Galveston, said in a university news release. "This concern has increased in the last few years based on the results of a clinical trial and two observational studies," he said. "It is important to note, ... Read more

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FDA Medwatch Alert: Testosterone Products: FDA/CDER Statement - Risk of Venous Blood Clots

Posted 24 Jun 2014 by Drugs.com

[Posted 06/20/2014] ISSUE:  FDA notified health professionals and their medical care organizations that it is requiring the manufacturers of all approved testosterone products to include a warning in the drug labeling about the risk of blood clots in the veins, also known as venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE). BACKGROUND: The risk of venous blood clots as a possible consequence of polycythemia is already included in the labeling of testosterone products. Because there have been postmarket reports of venous blood clots unrelated to polycythemia, FDA is requiring a change to drug labeling of all testosterone products to provide a more general warning regarding venous blood clots, to ensure this risk is described consistently in the labeling of all approved testosterone products. RECOMMENDATION: Note - This new warning, a class l ... Read more

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Testosterone Products Must Warn About Risk of Venous Clots: FDA

Posted 22 Jun 2014 by Drugs.com

FRIDAY, June 20, 2014 – The growing unease around the safety of testosterone supplements was highlighted Friday with a U.S. Food and Drug Administration announcement that the products must now carry a warning label on the general risk of blood clots in the veins. Testosterone therapy has been widely advertised as a way to help aging men with so-called "low T" improve their sex drive and reclaim diminished energy. The products already carry a warning about the risk of blood clots in the veins due to polycythemia, an abnormal rise in the number of red blood cells that sometimes occurs with testosterone treatment. In its statement Friday, the FDA said that after receiving reports of blood clots in the veins unrelated to polycythemia in patients taking testosterone products, it has now decided to require a more general warning on venous blood clots on the labelling. Blood clots in the ... Read more

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More Specialists Question Safety of Testosterone Therapy for Older Men

Posted 17 Feb 2014 by Drugs.com

MONDAY, Feb. 17, 2014 – Following the recent announcement from the U.S. Food and Drug Administration about the potential hazards of using testosterone supplements in older men, another group of experts is raising concerns about the popular treatments. In a statement, specialists in hormonal therapy at the Endocrine Society said the risks and benefits of testosterone supplements for older men with age-related declines in testosterone levels must be investigated more carefully. Older men considering such regimens should be warned about the possible risks, particularly heart-related events such as heart attack and stroke, the group said. The Endocrine Society issued the warning after three recent studies revealed testosterone may not be safe for older men with a history of heart disease. The studies found these men had more heart-related events than men not on testosterone therapy. For ... Read more

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FDA Medwatch Alert: Testosterone Products: Drug Safety Communication - FDA Investigating Risk of Cardiovascular Events

Posted 4 Feb 2014 by Drugs.com

[Posted 01/31/2014] ISSUE: FDA is investigating the risk of stroke, heart attack, and death in men taking FDA-approved testosterone products. We have been monitoring this risk and decided to reassess this safety issue based on the recent publication of two separate studies that each suggested an increased risk of cardiovascular events among groups of men prescribed testosterone therapy. FDA is providing this alert while it continues to evaluate the information from these studies and other available data. FDA will communicate final conclusions and recommendations when the evaluation is complete. BACKGROUND: Testosterone is a hormone essential to the development of male growth and masculine characteristics. Testosterone products are FDA-approved only for use in men who lack or have low testosterone levels in conjunction with an associated medical condition. RECOMMENDATION: At this time, ... Read more

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FDA Will Review Safety of Testosterone Therapy

Posted 3 Feb 2014 by Drugs.com

SUNDAY, Feb. 2, 2014 – Spurred by a recent report that popular testosterone treatments might raise men's heart risk, the U.S. Food and Drug Administration says it now plans a review of the therapies' safety. "FDA is investigating the risk of stroke, heart attack and death in men taking FDA-approved testosterone products," the agency said in a statement released late Friday. "We have been monitoring this risk and decided to reassess this safety issue based on the recent publication of two separate studies that each suggested an increased risk of cardiovascular events among groups of men prescribed testosterone therapy," the agency added. Testosterone therapy has been widely advertised as a way to help aging men improve low sex drive and reclaim diminished energy. However, in a study published Wednesday in the journal PLoS One, an increased risk of heart attack was found in men younger ... Read more

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Testosterone Therapy Might Increase Heart Attack Risk: Study

Posted 29 Jan 2014 by Drugs.com

WEDNESDAY, Jan. 29, 2014 – Testosterone therapy – widely advertised as a way to help men improve a low sex drive and reclaim diminished energy – might raise the risk of heart attack, according to new research. The increased risk was found in men younger than 65 with a history of heart disease, and in older men even if they didn't have a history of the disease. In both groups, heart attack risk doubled in the 90 days after the men began testosterone therapy, said researcher William Finkle, CEO of Consolidated Research, in Los Angeles. "It was more or less the same increase in risk," Finkle said. Testosterone therapy typically is given in gel, patch or injection form, and is widely promoted in television advertisements about "low T." Although the treatment risk to men over 65 has been documented in previous research, Finkle said, the new study is believed to be the first to look at men ... Read more

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