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Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery Blog

FDA Approves Eliquis to Reduce Risk of Blood Clots Following Hip Or Knee Replacement Surgery

Posted 18 Mar 2014 by Drugs.com

PRINCETON, N.J. & NEW YORK-- Friday, March 14, 2014 (BUSINESS WIRE)--Bristol-Myers Squibb Company (NYSE: BMY) and Pfizer Inc. (NYSE: PFE) today announced that the U.S. Food and Drug Administration (FDA) approved a Supplemental New Drug Application (sNDA) for Eliquis (apixaban) for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery. “Today’s FDA approval of Eliquis for DVT prophylaxis in patients who have undergone hip or knee replacement is a significant milestone for this important medicine, which is also approved to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation,” said Brian Daniels, M.D., senior vice president, global development and medical affairs, Bristol-Myers Squibb. “This approval reflects the continued commitment of the allianc ... Read more

Related support groups: Eliquis, Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery, Apixaban, Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery

Hip Surgery Increases Stroke Risk in Older Patients: Study

Posted 9 Nov 2012 by Drugs.com

FRIDAY, Nov. 9 – Patients who undergo total hip replacement are at greatly increased risk for stroke in the first few weeks after their surgery, a large new study says. The findings suggest that elderly people need to weigh the benefits of hip replacement against the risk of stroke, according to the researchers. The investigators compared more than 66,000 people in Denmark who had total hip replacement to nearly 200,000 people who did not have the procedure. The average age of the people in the study was 72. Most were white and female. The hip replacement patients had a 4.4-fold increased risk of hemorrhagic stroke – bleeding in the brain – in the two weeks after surgery, compared to people in the general population. They also had a nearly 4.7-fold increased risk of ischemic stroke – from blocked blood flow to the brain – during that time, the study authors found. The risk of ... Read more

Related support groups: Ischemic Stroke, Hip Replacement, Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery

FDA Expands Use of Xarelto to Treat, Reduce Recurrence of Blood Clots

Posted 2 Nov 2012 by Drugs.com

November 2, 2012 – The U.S. Food and Drug Administration today expanded the approved use of Xarelto (rivaroxaban) to include treating deep vein thrombosis (DVT) or pulmonary embolism (PE), and to reduce the risk of recurrent DVT and PE following initial treatment. Blood clots occur when blood thickens and clumps together. DVT is a blood clot that forms in a vein deep in the body. Most deep vein blood clots occur in the lower leg or thigh. When a blood clot in a deep vein breaks off and travels to an artery in the lungs and blocks blood flow, it results in a potentially deadly condition called PE. Xarelto is already FDA-approved to reduce the risk of DVTs and PEs from occurring after knee or hip replacement surgery (July 2011), and to reduce the risk of stroke in people who have a type of abnormal heart rhythm called non-valvular atrial fibrillation (November 2011). The FDA reviewed ... Read more

Related support groups: Xarelto, Deep Vein Thrombosis (DVT), Pulmonary Embolism, Deep Vein Thrombosis - First Event, Deep Vein Thrombosis, Deep Vein Thrombosis - Recurrent Event, Rivaroxaban, Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery, Deep Vein Thrombosis - Prophylaxis, Deep Vein Thrombosis Prophylaxis after Abdominal Surgery, Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery, Deep Vein Thrombosis Prophylaxis after Orthopedic Surgery, Deep Vein Thrombosis Prophylaxis after General Surgery

Joint Replacement Patients Face Blood Clot Risk in Hospital

Posted 17 Jan 2012 by Drugs.com

TUESDAY, Jan. 17 – One of every 100 people undergoing knee replacement surgery and 1 of 200 people having hip replacement surgery will develop a blood clot before they leave the hospital, even if they take steps to prevent the development of these blood clots, a new evidence review suggests. A deep venous thrombosis (DVT) or blood clot can form deep within the veins, usually in the leg. The real risk occurs if these blood clots dislodge, travel through your bloodstream, and block blood flow in your lungs, which is called pulmonary embolism. The new study, published in the Jan. 18 Journal of the American Medical Association, seeks to provide a reliable benchmark of this risk, but many experts in the field worry that the actual risk of blood clots after joint replacement is really much higher than this study suggests. Researchers led by Jean-Marie Januel, of the Lausanne University ... Read more

Related support groups: Knee Joint Replacement, Hip Replacement, Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery, Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery

FDA Approves Xarelto (rivaroxaban) to Prevent Deep Vein Thrombosis in Patients Undergoing Knee or Hip Replacement Surgery

Posted 1 Jul 2011 by Drugs.com

Raritan, NJ (July 1, 2011) — Janssen Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved Xarelto (rivaroxaban tablets), a novel, once-daily, oral anticoagulant for the prevention (prophylaxis) of deep vein thrombosis (DVT) which may lead to a pulmonary embolism (PE) in people undergoing knee or hip replacement surgery. "The approval of once-daily Xarelto tablets will provide a new option to help protect patients from developing venous blood clots following knee or hip replacement surgery," said Louis M. Kwong, M.D., Professor of Orthopedic Surgery at Harbor-UCLA Medical Center, who was involved with the rivaroxaban clinical trials program in this indication. "Xarelto has a proven clinical benefit over one of today’s most widely used options in preventing these potentially life-threatening blood clots, and the use of a once-daily pill may pl ... Read more

Related support groups: Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery, Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery

New Anti-Clotting Drug May Work Better After Hip Replacement

Posted 24 Dec 2010 by Drugs.com

WEDNESDAY, Dec. 22 – A new drug, apixaban, may be better for preventing dangerous blood clots in the legs and lungs after hip replacement surgery than a commonly used older drug, a new study finds. Researchers in Denmark compared the two anti-clotting drugs in a head-to-head test involving about 5,400 hip replacement patients. About 3.9 percent of patients given the older drug, enoxaparin, developed venous thromboembolism (clot in the legs), a pulmonary embolism (clot in the lungs) or died after the surgery, according to the study. That compares to only 1.4 percent of patients given apixaban. Apixaban is being developed by Bristol-Myers Squibb and Pfizer, which funded the Phase III trial reported in the Dec. 23 issue of the New England Journal of Medicine. The company has applied to the U.S. Food and Drug Administration for drug approval and expects to complete the application process ... Read more

Related support groups: Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery

Compression Device May Outperform Meds After Hip Surgery

Posted 8 Apr 2010 by Drugs.com

THURSDAY, April 8 – After hip replacement surgery, a compression device works as well as medication – and is safer – for preventing blood clots, a new study suggests. "This device is as useful as blood thinners for the reduction of blood clots after hip replacement, and it's superior in safety," said study co-author Dr. Douglas E. Padgett, chief of adult reconstruction and joint replacement at the Hospital for Special Surgery in New York City, in a statement. "This has the potential to change the paradigm as to how we prevent blood clots after hip replacement. The efficacy is the same, the safety is markedly better and the cost is comparable." An estimated 30 percent to 50 percent of hip or knee replacement surgery patients will develop blood clots if preventive measures, such as taking blood thinning medication, aren't taken. In the study, researchers looked at a compression device ... Read more

Related support groups: Hip Replacement, Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery

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Coumadin, warfarin, Xarelto, Lovenox, Eliquis, enoxaparin, rivaroxaban, Clexane, Arixtra, view more... Jantoven, fondaparinux, apixaban, Clexane Forte, Arixtra 10 mg / dose, Arixtra 7.5 mg / dose, Arixtra 5 mg / dose, Lovenox HP, anisindione, Miradon