Join the 'Crohn's Disease - Maintenance' group to help and get support from people like you.

Crohn's Disease - Maintenance Blog

Scientists Grow, Implant Human Intestinal Tissue in Mice

Posted 20 Oct 2014 by Drugs.com

SUNDAY, Oct. 19, 2014 – New stem cell-based research could improve understanding of intestinal diseases and eventually lead to new treatments, a new study suggests. Scientists used stem cells to grow "organoids" of functioning human intestinal tissue in a lab dish. They then transplanted the organoids into mice, creating a new model for studying intestinal disorders, according to the researchers. "This provides a new way to study the many diseases and conditions that can cause intestinal failure, from genetic disorders appearing at birth to conditions that strike later in life, such as cancer and Crohn's disease," lead investigator Dr. Michael Helmrath, surgical director of the Intestinal Rehabilitation Program at the Cincinnati Children's Hospital Medical Center, said in a center news release. "These studies also advance the longer-term goal of growing tissues that can replace damaged ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Entyvio Approved for Ulcerative Colitis and Crohn's Disease

Posted 20 May 2014 by Drugs.com

TUESDAY, May 20, 2014 – Entyvio (vedolizumab) has been approved by the U.S. Food and Drug Administration to treat adults with moderate-to-severe forms of two gastrointestinal conditions – ulcerative colitis and Crohn's disease. The approval applies to people for whom standard therapies – such as corticosteroids or tumor necrosis factor-blocking medications – have failed. Ulcerative colitis, affecting about 620,000 Americans, causes inflammation and ulcers in the large intestine. This can lead to abdominal discomfort, bleeding and diarrhea, the FDA said in a news release. Crohn's causes inflammation and irritation of any part of the gastrointestinal tract. More than 500,000 Americans have been diagnosed with Crohn's, the FDA said. The most common side effects of Entyvio include headache, joint pain, nausea and fever. More serious adverse reactions observed during clinical testing ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance

Scientists Now See 200 Genes Linked to Crohn's Disease

Posted 19 Dec 2012 by Drugs.com

WEDNESDAY, Dec. 19 – Using a new technique, researchers have pinpointed a large number of additional genes associated with Crohn's disease, bringing the total to 200. The scientists at University College London, in England, created a new method to identify and map the locations of genes associated with complex inherited diseases such as Crohn's. Crohn's disease, a type of inflammatory bowel disease, affects about 100 to 150 people out of every 100,000. Understanding more about the genes associated with the disease may lead to improved treatments, the researchers said. The 200 genes so far linked to Crohn's are more than have been found for any other disease, according to the researchers. For example, just 66 gene regions are known for type 2 diabetes. "The discovery of so many gene locations for Crohn's disease is an important step forward in understanding the disease, which has a very ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Mouse Study Suggests Certain Fats Could Trigger Crohn's, Colitis

Posted 13 Jun 2012 by Drugs.com

WEDNESDAY, June 13 – Certain types of saturated fats common in today's Western diet may change gut bacteria and trigger inflammatory bowel disease in people genetically predisposed to the disorder, according to a new study that looked at this relationship in mice. Inflammatory bowel disease includes ulcerative colitis and Crohn's disease. The University of Chicago researchers said their findings help explain why once rare immune-system-related disorders such as inflammatory bowel disease have become more common in the United States and other Westernized nations in the last half-century. The researchers said their study may shed some light on why many people who are genetically prone to the condition still don't develop it and how certain environmental factors can cause inflammation in those at risk. Scientists note, however, that research with animals often fails to provide similar ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Crohn's Disease - Acute, Ulcerative Colitis - Maintenance

Chronic Bowel Disease Drugs Linked to Skin Cancer Risk

Posted 23 Nov 2011 by Drugs.com

TUESDAY, Nov. 22 – Some patients with inflammatory bowel disease may be at increased risk for skin cancer due to their use of immunosuppressant drugs to treat the intestinal disorder, according to the results of two new studies. The studies, published in the November issue of the journal Gastroenterology, noted that immunosuppressants are commonly used to treat patients with inflammatory bowel disease, or IBD. Currently, there are no specific recommendations for skin cancer screening in IBD patients. In one study, French researchers led by Dr. Laurent Peyrin-Biroulet, of University Hospital of Nancy, found that both past and present use of a widely used class of immunosuppressants called thiopurines significantly increased the risk of non-melanoma skin cancer in irritable bowel disease patients. "The increased risk of skin cancer that we found in our study was observed in all patients, ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Basal Cell Carcinoma, Ulcerative Colitis - Active, Crohn's Disease - Acute, Inflammatory Bowel Disease, Ulcerative Colitis - Maintenance, Squamous Cell Carcinoma

People With Bowel Disease at Higher Risk of Blood Clot in Lungs, Legs

Posted 22 Feb 2011 by Drugs.com

TUESDAY, Feb. 22 – People with inflammatory bowel disease have double the risk of developing a potentially deadly blood clot (venous thromboembolism) in the legs or lungs as do people in the general public, a new study finds. Inflammatory bowel disease includes Crohn's disease and ulcerative colitis, both of which can cause abdominal pain, vomiting, diarrhea, weight loss and other problems. Venous thromboembolism (VTE) – which includes deep vein thrombosis, pulmonary embolism and superior sagittal sinus thrombosis – affects about two in every 1,000 people a year in the United States and other developed nations. Researchers compared the number of new cases of VTE diagnosed between 1980 and 2007 in nearly 50,000 adults and children with IBD and more than 477,000 members of the general public. After they factored in known VTE risk factors such as a broken bone, cancer, surgery and ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Crohn's Disease - Acute, Inflammatory Bowel Disease, Ulcerative Colitis - Maintenance

Drugs for Inflammatory Bowel Disease Might Increase Cancer Risk

Posted 16 Jul 2010 by Drugs.com

MONDAY, Oct. 19 – The use of thiopurine drugs to treat inflammatory bowel disease (IBD) increases the risk of cancers related to viral infection, according to a new study. IBD includes Crohn's disease and ulcerative colitis. Thiopurine drugs are used to suppress the immune system in order to maintain remission in IBD patients. For this study, French researchers analyzed data on 19,486 IBD patients (60 percent with Crohn's and 40 percent with ulcerative colitis or unclassified IBD) who were followed for a median of 35 months. At the start of the study, 30 percent of patients were taking thiopurines, 14 percent had discontinued them, and 56 percent had never received thiopurines. During the study, 23 patients developed malignant lymphoproliferative disorders (LD) – cancers that are associated with viral infection, particularly those linked to Epstein Barr virus (EBV) infection. Of the ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Crohn's Disease - Maintenance, Imuran, Ulcerative Colitis - Active, Crohn's Disease - Acute, Azathioprine, Inflammatory Bowel Disease, Ulcerative Colitis - Maintenance, Mercaptopurine, Azasan, Purinethol, Thioguanine, Tabloid

Virus Plus Gene Mutation Spurs Crohn's Disease in Mice

Posted 24 Jun 2010 by Drugs.com

THURSDAY, June 24 – Mice with a gene variant linked to Crohn's disease only develop the inflammatory bowel disorder if they are infected by a common norovirus called MNV, finds a new study. Noroviruses are a group of viruses that cause gastroenteritis, an inflammation of the stomach lining. Two years ago, the researchers at Washington University School of Medicine in St. Louis and others discovered that mice with an ATG16L1 gene variant associated with Crohn's disease in humans develop similar abnormalities in gut immune cells called Paneth cells. But the mutation alone wasn't enough to trigger Crohn's disease. In a routine screening, the team later found that mice with the gene variant developed Crohn's disease symptoms within seven days after exposure to the MNV norovirus. The study appears in the June 25 issue of the journal Cell. It's been suspected that autoimmune and other ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Better Treatment Found for Crohn's Disease

Posted 15 Apr 2010 by Drugs.com

WEDNESDAY, April 14 – Combination therapy with two drugs that control an unruly immune system provided the best relief yet seen for Crohn's disease, a condition in which the body mistakenly attacks its own intestinal tissue. The new finding promises to change current treatment of Crohn's disease, said study leader Dr. William J. Sandborn, vice chair of gastroenterology and hepatology at the Mayo Clinic in Rochester, Minn. The results were reported in the April 15 issue of the New England Journal of Medicine. Doctors now start treatment of Crohn's disease with steroids, Sandborn said. If the steroids do not provide relief from the abdominal pain, nausea, fever, weight loss, diarrhea and other symptoms of the condition, the next step is to use azathioprine, which reduces immune system activity broadly. Only if that fails will they try biologics, newer treatments that include monoclonal ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Inflammatory Bowel Ups Risk for Blood Clots

Posted 9 Feb 2010 by Drugs.com

TUESDAY, Feb. 9 – People with active inflammatory bowel disease are much more likely to develop blood clots than people without the condition, a new study suggests. And that may make preventive drug treatment necessary, it adds. The study, done in the United Kingdom, compared data on 13,756 people who had inflammatory bowel disease (IBD) with 71,672 people who did not have it. None of the people were hospitalized. Between November 1987 and July 2001, 304 people developed a blood clot (venous thromboembolism). Overall, people with IBD were found to be 3.4 times more likely to develop a blood clot and eight times more likely at the time of an IBD flare. But the risk rose to 16 times higher if a flare occurred when the person was not hospitalized. The study was published online Feb. 8 in The Lancet. The researchers said the findings suggest that active IBD might be a far greater risk ... Read more

Related support groups: Crohn's Disease, Colitis, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Crohn's Disease - Acute, Inflammatory Bowel Disease, Ulcerative Colitis - Maintenance

Bowel Disease Treatment May Raise Skin Cancer Risk

Posted 2 Dec 2009 by Drugs.com

MONDAY, Oct. 26 – Inflammatory bowel disease (IBD) patients who are being treated with immunosuppressive medications may be at increased risk for non-melanoma skin cancer, a new U.S. study says. Researchers analyzed data on 26,403 Crohn's disease patients and 26,974 patients with ulcerative colitis in order to evaluate how the use of immunosuppressive and biologic medications to treat IBD affected non-melanoma skin cancer risk. The study found that the incidence of non-melanoma skin cancer was higher in IBD patients than in a control group. Recent use (within 90 days) of any immunosuppressive medication was associated with greater risk of non-melanoma skin cancer (adjusted odds ratio 3.28), as was recent use of the thiopurine class of immunosuppressive medications (adjusted odds ratio 3.56) and recent use of biologic medications in Crohn's disease patients (adjusted odds ratio 2.07). ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Crohn's Disease - Maintenance, Imuran, Ulcerative Colitis - Active, Crohn's Disease - Acute, Azathioprine, Inflammatory Bowel Disease, Ulcerative Colitis - Maintenance, Mercaptopurine, Azasan, Purinethol, Thioguanine, Tabloid

Gene Discovery Gives Clues to Crohn's Disease, Colitis

Posted 1 Dec 2009 by Drugs.com

WEDNESDAY, Nov. 4 – People with painful, chronic bowel conditions such as Crohn's disease and ulcerative colitis could see a glimmer of hope from new research. Scientists say they've spotted a genetic flaw that could drive a rare childhood form of colitis, and the finding might have implications for the broader range of illnesses collectively known as inflammatory bowel disease (IBD). Genetic analysis of nine children with a severe form of early-onset colitis found mutations of two genes producing cell receptors for interleukin-10, a protein that controls the body's inflammatory response, according to a report published online Nov. 4 in the New England Journal of Medicine. In one case, a bone marrow transplant eliminated a child's disease, the report said. About one million Americans have been diagnosed with IBD, which includes ulcerative colitis and Crohn's disease. These conditions ... Read more

Related support groups: Crohn's Disease, Ulcerative Colitis, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Crohn's Disease - Acute, Inflammatory Bowel Disease, Ulcerative Colitis - Maintenance

Two Drugs Better Than One for Crohn's Patients

Posted 3 Jun 2009 by Drugs.com

WEDNESDAY, June 3 – Crohn's disease patients who received a combination of the drugs infliximab (Remicade) and azathioprine (Azasan) were more likely to have the disease go into steroid-free remission than those who received only one of the drugs, researchers say. The study was presented Tuesday at Digestive Disease Week 2009 in Chicago. Crohn's disease is an inflammation of the digestive tract, most often the lining and wall of the lower small intestine, or the ileum, according to the National Digestive Diseases Information Clearinghouse. When inflamed, the lining of the intestinal wall can become swollen, causing diarrhea. Severe cases can require surgery. In an international study, researchers divided 508 patients with moderate to severe Crohn's who had not yet received immunomodulator drugs into three groups. One group received infliximab plus azathioprine, a second group received ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Scientists Discover New Drug Targets for Crohn's Disease

Posted 26 Feb 2009 by Drugs.com

THURSDAY, Feb. 26 – An international team of researchers has pinpointed new genetic targets for drugs to treat Crohn's disease, a chronic and painful condition caused by inflammation of the gastrointestinal tract. The Children's Hospital of Philadelphia-led group used a new gene-searching method, combining a statistical tool that identifies genes interacting on the same biological pathways with highly automated gene-hunting techniques that scan the whole genome. An initial analysis was performed on DNA from 1,758 Crohn's patients and 1,480 people without the disease. All of them were of European ancestry. The analysis was repeated in three more groups, of both European and African ancestry. "Among hundreds of known biological pathways, the one that surfaced from the analysis as being most significant included genes already known to be relevant to the biology of Crohn's disease," study ... Read more

Related support groups: Crohn's Disease, Crohn's Disease - Maintenance, Crohn's Disease - Acute

Ask a Question

Further Information

Related Condition Support Groups

Crohn's Disease

Related Drug Support Groups

metronidazole, Humira, Flagyl, Remicade, Asacol, Tysabri, Imuran, Pentasa, sulfasalazine, view more... Cimzia, budesonide, azathioprine, mercaptopurine, mesalamine, Metro, Entocort EC, Flagyl IV, infliximab, Asacol HD, adalimumab, natalizumab, Azasan, Salofalk, Purinethol, Canasa Pac, Flagyl 375, certolizumab, Mesasal Enteric Coated, Metro IV, Metryl, FIV-ASA, Protostat