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Carbidopa/Levodopa Blog

Experimental Gel May Help Those With Advanced Parkinson's

Posted 18 Apr 2012 by Drugs.com

WEDNESDAY, April 18 – A gel form of two common Parkinson's drugs delivered via a feeding tube-like device may help people with advanced disease reduce medication side effects and possibly avoid brain surgery. That's the report from researchers who found the experimental levodopa-carbidopa intestinal gel works better than a standard pill regimen in reducing "off" time in people with advanced Parkinson's disease. About 1 million people in the United States are living with Parkinson's disease, a progressive movement disorder marked by tremor, slowness and/or rigidity. The disease slowly destroys the nerve cells in the brain that produce the chemical dopamine, which controls muscle movement. Treatment with oral levodopa-carbidopa – brand names include Sinemet, Sinemet CR and Parcopa – helps replace dopamine levels, but higher doses and long-term use of the oral drugs can cause ... Read more

Related support groups: Parkinson's Disease, Sinemet, Sinemet CR, Carbidopa/Levodopa, Parcopa, Atamet

Parkinson's Drugs Linked to Behavior Problems in Study

Posted 30 Mar 2011 by Drugs.com

TUESDAY, March 29 – Parkinson's disease drugs called dopamine agonists appear to cause impulse control problems in almost one-quarter of patients, says a new study. Previous research has linked dopamine agonists, which include Mirapex (pramipexole) and Requip (ropinirole), to impulse control disorders, such as gambling addiction and hypersexuality, and to compulsive behaviors, such as binge eating, overspending and excessive computer use. In this study, Mayo Clinic researchers analyzed Parkinson's disease patient records over two years. "What we found was that as many as 22 percent of patients during that two-year period had a new-onset impulse control disorder," lead investigator and neurology fellow Dr. Anhar Hassan said in a Mayo Clinic news release. The higher the dose of dopamine agonist, the more likely a patient was to develop an impulse control disorder, the researchers found. ... Read more

Related support groups: Parkinson's Disease, Mirapex, Requip, Sinemet, Ropinirole, Emsam, Azilect, Pramipexole, Levodopa, Bromocriptine, Carbidopa, Cabergoline, Selegiline, Amantadine, Parlodel, Neupro, Dostinex, Stalevo, Sinemet CR, Requip XL

Parkinson's Drugs Tied to Compulsive Behaviors

Posted 10 May 2010 by Drugs.com

MONDAY, May 10 – Medicines used to treat Parkinson's disease may increase the risk of impulse control disorders, such as problem gambling, compulsive shopping and binge eating, researchers warn. In a new study that included 3,090 patients being treated for Parkinson's at 46 movement disorder centers in the United States and Canada, the researchers found that 13.6 percent of the patients had impulse control disorders. These impulse disorders included gambling (5 percent), compulsive sexual behavior (3.5 percent), compulsive shopping (5.7 percent) and binge eating (4.3 percent), and nearly 4 percent of the patients had two or more of these disorders. Impulse control disorders were more common among patients taking dopamine agonist medications (17.1 percent) than in those not taking the drugs (6.9 percent), the study authors found. Other factors associated with impulse control disorders ... Read more

Related support groups: Parkinson's Disease, Mirapex, Requip, Sinemet, Ropinirole, Emsam, Azilect, Pramipexole, Levodopa, Bromocriptine, Carbidopa, Cabergoline, Selegiline, Amantadine, Parlodel, Neupro, Dostinex, Stalevo, Sinemet CR, Requip XL

Cutting Parkinson's Drug Dose Linked to Withdrawal Effects

Posted 14 Jan 2010 by Drugs.com

WEDNESDAY, Jan. 13 – Reduced dosages of dopamine agonists, drugs routinely used to treat Parkinson's disease, can cause symptoms similar to those experienced by addicts in withdrawal, such as anxiety, panic attacks, pain, dizziness and drug cravings, researchers say. The symptoms of what the researchers have dubbed "dopamine agonist withdrawal syndrome" have been linked to a disruption in levels of dopamine in the brain, according to the study published in the Jan. 12 issue of the Archives of Neurology. "Like cocaine and methamphetamines, dopamine agonists work by stimulating the reward pathways in the brain," senior study author Dr. Melissa J. Nirenberg, said in a news release from Weill Cornell Medical Center. "For this reason, it makes sense that they would engender similar withdrawal symptoms, particularly in those with high cumulative drug exposure," explained Nirenberg, associate ... Read more

Related support groups: Parkinson's Disease, Mirapex, Requip, Sinemet, Ropinirole, Emsam, Azilect, Pramipexole, Levodopa, Bromocriptine, Carbidopa, Selegiline, Amantadine, Parlodel, Neupro, Stalevo, Requip XL, Carbidopa/Levodopa, Sinemet CR, Comtan

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Further Information

Related Condition Support Groups

Parkinson's Disease, Restless Legs Syndrome, Neuroleptic Malignant Syndrome, GTP-CH Deficiency

Related Drug Support Groups

Sinemet, Sinemet CR, Parcopa, Atamet

Carbidopa/Levodopa Patient Information at Drugs.com