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Clues to How Popular Heartburn Drug Might Harm Arteries

Posted 16 days ago by Drugs.com

TUESDAY, May 10, 2016 – A popular over-the-counter heartburn medication accelerated aging of blood vessel cells in lab tests, raising red flags about its long-term effect on heart health, researchers say. Faster aging of blood vessel cells exposed to the antacid Nexium (esomeprazole) might potentially hinder the tasks these cells perform to prevent heart attack and stroke, the new study suggests. These lab results could explain why other studies have shown increased risk of heart disease in people who use proton pump inhibitors (PPIs) – the class of heartburn medication that includes Nexium, said study senior author Dr. John Cooke. "Our finding that the lining of blood vessels is impaired by proton pump inhibitors is a unifying mechanism for the reports that PPI users are at increased risk for heart attack, stroke and renal failure," said Cooke, chair of cardiovascular sciences at the ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Indigestion, Pantoprazole, Dexilant, Lansoprazole, Prevacid, Tums, Milk of Magnesia, Aciphex, Caltrate, Duodenitis/Gastritis, Calcium Carbonate, Sodium Bicarbonate, Esomeprazole, Rabeprazole, Zegerid

1 in 4 Hospitalized Newborns Gets Heartburn Drugs, Despite Risks

Posted 27 Apr 2016 by Drugs.com

WEDNESDAY, April 27, 2016 – Despite reported risks, nearly one in four infants in neonatal intensive care units (NICUs) are given stomach acid-suppressing drugs, researchers report. However, they noted that the use of these medications has started to decline some in recent years. A number of studies have linked the use of stomach acid-suppressing drugs in hospitalized high-risk infants with infections, necrotizing enterocolitis (a serious disease where intestinal tissue begins to die off) and increased risk of death, the researchers said. These drugs include histamine-2 receptor antagonists such as ranitidine (Zantac), and proton pump inhibitors such as esomeprazole (Nexium). Researchers at Nationwide Children's Hospital in Columbus, Ohio, analyzed data from 43 children's hospitals across the United States from 2006 to 2013. They found that nearly 24 percent of roughly 122,000 newborns ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Dexilant, Prevacid, Lansoprazole, Pepcid, Delivery, Aciphex, Famotidine, Heartburn Relief, Rabeprazole, Esomeprazole, Zegerid, Vimovo, Zantac 150

Widely Used Heartburn Drugs Linked to Dementia Risk in Study

Posted 15 Feb 2016 by Drugs.com

MONDAY, Feb. 15, 2016 – A popular class of heartburn medications might raise a senior's risk of dementia, a new study suggests. Called proton pump inhibitors (PPIs), this group of drugs includes Prilosec, Nexium and Prevacid. They work by lowering the amount of acid produced by the stomach. But German researchers found that people 75 or older who regularly take the medications had a 44 percent increased risk of dementia, compared with seniors not using the drugs. The study only found an association, however, and not a cause-and-effect link. "To evaluate cause-and-effect relationships between long-term PPI use and possible effects on cognition in the elderly, randomized, prospective clinical trials are needed," said corresponding author Britta Haenisch, from the German Center for Neurodegenerative Diseases in Bonn. In the meantime, "Clinicians should follow guidelines for PPI ... Read more

Related support groups: GERD, Gas, Omeprazole, Nexium, Dementia, Prilosec, Protonix, Indigestion, Pantoprazole, Alzheimer's Disease, Stomach Ulcer, Dexilant, Prevacid, Lansoprazole, Gastric Ulcer, Aciphex, Peptic Ulcer, Duodenitis/Gastritis, Prevpac, Mild Cognitive Impairment

Heartburn Meds Linked to Chronic Kidney Disease

Posted 11 Jan 2016 by Drugs.com

MONDAY, Jan. 11, 2016 – A type of heartburn medication called proton pump inhibitors may be linked to long-term kidney damage, a new study suggests. Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach. People who use proton pump inhibitors (PPIs) have a 20 percent to 50 percent higher risk of chronic kidney disease compared with nonusers, said lead author Dr. Morgan Grams, an assistant professor of epidemiology at Johns Hopkins University in Baltimore. The study was published Jan. 11 in JAMA Internal Medicine. The study doesn't establish a direct cause-and-effect relationship between the drugs and chronic kidney disease. However, Grams said, "We found there was an increasing risk associated with an increasing dose. That suggests that perhaps this observed effect is real." Proton pump ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Renal Failure, Pantoprazole, Dexilant, Lansoprazole, Prevacid, Aciphex, Chronic Kidney Disease, Rabeprazole, Zegerid, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Kapidex, Dexlansoprazole, Zegerid OTC

Chronic Heartburn Drugs Tied to Higher Risk of Kidney Disease

Posted 27 Oct 2015 by Drugs.com

TUESDAY, Oct. 27, 2015 – A common type of heartburn medication called proton pump inhibitors (PPIs) seem to be linked with increased risk of chronic kidney disease, two new studies suggest. Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach. While the current studies have shown an association between these drugs and the development of chronic kidney disease, they did not prove a cause-and-effect relationship. Still, the lead author of one of the studies believes, "It is very reasonable to assume that PPIs themselves can cause chronic kidney disease," said Dr. Pradeep Arora, a nephrologist and associate professor at the SUNY Buffalo School of Medicine and Biomedical Science in Buffalo, N.Y. "Patients should only use PPIs for [U.S. Food and Drug Administration]-approved indications, and ... Read more

Related support groups: High Blood Pressure, Diabetes, Type 2, GERD, Hypertension, Omeprazole, Nexium, Prilosec, Protonix, Renal Failure, Indigestion, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Chronic Kidney Disease, Duodenitis/Gastritis, Zegerid, Rabeprazole, Esomeprazole

Popular Heartburn Meds Linked to Higher Risk of Heart Attack

Posted 10 Jun 2015 by Drugs.com

WEDNESDAY, June 10, 2015 – People who use certain heartburn drugs for a long period of time may have a slightly heightened risk of suffering a heart attack, a new study suggests. Using medical records from nearly 300,000 U.S. adults with acid reflux disease (commonly called heartburn), researchers found that the risk of heart attack was slightly elevated among those using proton pump inhibitors. Proton pump inhibitors are a group of acid-suppressing drugs that include brand-names such as Prevacid, Prilosec and Nexium. In 2009, they were the third most commonly used type of drug in the United States, the researchers said. The study, funded by the U.S. National Institutes of Health, does not prove the drugs cause heart attack. And experts were divided over what to make of the connection. Another class of heartburn drug – so-called H2-blockers – was not linked to any increase in heart ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Indigestion, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Duodenitis/Gastritis, Rabeprazole, Esomeprazole, Zegerid, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC

Antacids May Improve Head and Neck Cancer Survival

Posted 2 Dec 2014 by Drugs.com

TUESDAY, Dec. 2, 2014 – Using antacids to control acid reflux may improve head and neck cancer patients' chances of survival, a new study suggests. The researchers examined the effects that two types of antacids – proton pump inhibitors and histamine 2 blockers – had on head and neck cancer patients. More than two-thirds of the nearly 600 patients in the study took one or both types of the antacids after their cancer diagnosis. Acid reflux – commonly known as heartburn – is a common side effect of chemotherapy or radiation treatment, according to the researchers. Proton pump inhibitors include drugs such as Prilosec, Nexium and Prevacid, while histamine 2 blockers include drugs such as Tagamet, Zantac and Pepcid. Compared to patients who didn't take antacids, those who took proton pump inhibitors had a 45 percent lower risk of death, according to the researchers. They also found ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Dexilant, Lansoprazole, Prevacid, Pepcid, Aciphex, Famotidine, Heartburn Relief, Rabeprazole, Esomeprazole, Zegerid, Zantac 150, Pepcid AC, Pepcid Complete

Could Popular Heartburn Drugs Upset Your 'Good' Gut Bugs?

Posted 25 Nov 2014 by Drugs.com

TUESDAY, Nov. 25, 2014 – Heartburn drugs such as Prilosec and Nexium may disrupt the makeup of bacteria in the digestive system, potentially boosting the risk of infections and other problems, a small new study suggests. The research doesn't confirm that these changes make it more likely users will become ill, and study authors aren't recommending that anyone stop taking the so-called proton pump inhibitors. However, these antacids "should be used at the lowest dose that provides adequate relief of symptoms, and attempts to discontinue their use should be considered periodically," said study co-author Dr. John DiBaise, professor of medicine at the Mayo Clinic in Scottsdale, Ariz. According to Harvard Medical School, billions of dollars are spent annually on antacid drugs in an attempt to combat heartburn, ulcers and gastroesophageal reflux disease, also known as GERD. Old standbys such ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Esomeprazole, Zegerid, Rabeprazole, Prilosec OTC, Prevacid SoluTab, Kapidex, Dexlansoprazole, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Prevacid OTC

Take Heartburn Medicines Before Breakfast for Best Effect

Posted 11 Jun 2014 by Drugs.com

WEDNESDAY, June 11, 2014 – Many people with heartburn aren't taking their acid-reducing medicine at the right time, which makes the drugs less effective and wastes money, according to new research. Only about one-third of those buying these medications – such as Nexium, Prevacid and Prilosec – over-the-counter used them properly compared to just under half of those who were prescribed the drugs by their primary care doctor. Those who were given a prescription by a gastroenterologist were most likely to use the drugs as they're supposed to be used, with seven out of 10 taking the drugs properly, according to the study. These drugs are activated once in the body, said the study's senior author, Dr. M. Michael Wolfe, a gastroenterologist and chair of the department of medicine at MetroHealth System. "In order to activate the medicine, you must eat. For that reason, you take it before ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Esomeprazole, Zegerid, Rabeprazole, Prilosec OTC, Prevacid SoluTab, Kapidex, Dexlansoprazole, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Prevacid OTC

Acid-Reflux Drugs Tied to Lower Levels of Vitamin B-12

Posted 10 Dec 2013 by Drugs.com

TUESDAY, Dec. 10, 2013 – People who take certain acid-reflux medications might have an increased risk of vitamin B-12 deficiency, according to new research. Taking proton pump inhibitors (PPIs) to ease the symptoms of excess stomach acid for more than two years was linked to a 65 percent increase in the risk of vitamin B-12 deficiency. Commonly used PPI brands include Prilosec, Nexium and Prevacid. Researchers also found that using acid-suppressing drugs called histamine-2 receptor antagonists – also known as H2 blockers – for two years was associated with a 25 percent increase in the risk of B-12 deficiency. Common brands include Tagamet, Pepcid and Zantac. "This study raises the question of whether or not people who are on long-term acid suppression need to be tested for vitamin B-12 deficiency," said study author Dr. Douglas Corley, a research scientist and gastroenterologist at ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Dexilant, Lansoprazole, Prevacid, Pepcid, Aciphex, Famotidine, Heartburn Relief, Vitamin B12 Deficiency, Rabeprazole, Esomeprazole, Zegerid, Zantac 150

Generic Aciphex Approved to Treat Chronic Heartburn

Posted 8 Nov 2013 by Drugs.com

FRIDAY, Nov. 8 – The first generic versions of the anti-GERD drug Aciphex (rabeprazole sodium) have been approved by the U.S. Food and Drug Administration for people aged 12 and older, the agency said Friday. Gastroesophageal reflux disease (GERD), also known as chronic heartburn, is a very common disorder characterized by backward flow of stomach acid to the esophagus. This process could damage tissue in the esophagus, the tube that connects the throat and stomach. License to produce generic rabeprazole was granted to Dr. Reddy's Laboratories, Kremers Urban Pharmaceuticals, Lupin Pharmaceuticals, Mylan Pharmaceuticals, Teva Pharmaceuticals and Torrent Pharmaceuticals, the FDA said. The drug is among a class called proton-pump inhibitors, which are designed to reduce the amount of stomach acid produced. Generic drugs, the FDA stressed, are equivalent to the brand-name versions in ... Read more

Related support groups: GERD, Aciphex, Rabeprazole

FDA Approves Aciphex Sprinkle (rabeprazole sodium) For Use in Children Ages 1 to 11

Posted 16 Apr 2013 by Drugs.com

Woodcliff Lake, NJ, March 26, 2013 - Eisai Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved Aciphex Sprinkle Delayed-Release Capsules 5mg and 10mg for the treatment of Gastroesophageal Reflux Disease (GERD) in children 1 to 11 years of age for up to 12 weeks. “We are proud to offer a new treatment option for young children who suffer from GERD,” said Lonnel Coats, president and CEO of Eisai Inc. “Eisai is committed to keeping the medical needs of patients and their families at the forefront of all that we do, as part of our human health care (hhc) corporate mission.” The approval of Aciphex Sprinkle is based on the results of a clinical trial of pediatric patients 1 to 11 years of age. The clinical trial was a multicenter, double-blind, parallel-group study conducted in 127 pediatric patients with endoscopically-proven GERD that consisted of a 12-week ... Read more

Related support groups: GERD, Aciphex, Rabeprazole, Gastroesophageal Reflux Disease

Health Tip: Before You Take This Heartburn Medication...

Posted 5 Apr 2013 by Drugs.com

-- A proton pump inhibitor, a drug commonly taken for heartburn, may cause side effects. The American Academy of Family Physicians lists these factors to consider before using a proton pump inhibitor (PPI): If you're a postmenopausal woman, talk with your doctor because a PPI could increase your risk for bone fractures. If you've been treated for a C. difficile infection, check with your doctor because PPIs may increase the risk of the infection returning. If you have problems with your immune system or are elderly, check with your doctor because PPIs may increase the risk of pneumonia. Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Esomeprazole, Zegerid, Rabeprazole, Prilosec OTC, Prevacid SoluTab, Kapidex, Dexlansoprazole, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Protonix IV

Heartburn Meds May Often Be Taken for Too Long, at Too-High Doses

Posted 22 Feb 2013 by Drugs.com

FRIDAY, Feb. 22 – U.S. veterans with chronic heartburn are often prescribed higher-than-recommended doses of medicines to control the condition and many are kept on the drugs far too long, according to a new study. Researchers looked at 1,600 veterans who were diagnosed with chronic heartburn – also known as gastroesophageal reflux disease (GERD) – and prescribed a type of drug called a "proton pump inhibitor," such as Prilosec (omeprazole). GERD arises when the ring of muscle between the esophagus and stomach fails to close properly, allowing stomach acids to splash up into the esophagus. The main symptom is chronic heartburn. These drugs – which also include Prevacid (lansoprazole) and Nexium (esomeprazole) – are among the most widely used drugs in the United States and provide relief for many patients with chronic heartburn. However, proper prescribing is required to avoid ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Esomeprazole, Zegerid, Rabeprazole, Prilosec OTC, Prevacid SoluTab, Kapidex, Dexlansoprazole, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Protonix IV

Which Hospital Patients Need Drugs to Prevent Gastrointestinal Bleeding?

Posted 10 Jan 2013 by Drugs.com

THURSDAY, Jan. 10 – Researchers have developed a scoring system to help doctors determine which hospital patients can be prescribed stomach acid-suppressing drugs to prevent gastrointestinal bleeding and which patients should not be given such medications. Gastrointestinal bleeding in hospital patients is rare, but it is dangerous and potentially fatal, according to the study authors. Although the use of acid suppressants to prevent gastrointestinal bleeding in patients who are not critically ill is not widely recommended, the medications are commonly used for this purpose, said Shoshana Herzig and colleagues at the Beth Israel Deaconess Medical Center in Boston. The study was published online recently in the Journal of General Internal Medicine. The researchers analyzed data from more than 75,000 hospital patients admitted over three years and found that gastrointestinal bleeding ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Dexilant, Lansoprazole, Prevacid, Pepcid, Aciphex, Famotidine, Heartburn Relief, Zegerid, Rabeprazole, Esomeprazole, Zantac 150, Pepcid AC, Pepcid Complete

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Barrett's Esophagus, GERD, Erosive Esophagitis, Duodenal Ulcer, Zollinger-Ellison Syndrome, Helicobacter Pylori Infection, Duodenal Ulcer Prophylaxis, Stomach Ulcer, Gastric Ulcer

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