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Take Heartburn Medicines Before Breakfast for Best Effect

Posted 11 Jun 2014 by Drugs.com

WEDNESDAY, June 11, 2014 – Many people with heartburn aren't taking their acid-reducing medicine at the right time, which makes the drugs less effective and wastes money, according to new research. Only about one-third of those buying these medications – such as Nexium, Prevacid and Prilosec – over-the-counter used them properly compared to just under half of those who were prescribed the drugs by their primary care doctor. Those who were given a prescription by a gastroenterologist were most likely to use the drugs as they're supposed to be used, with seven out of 10 taking the drugs properly, according to the study. These drugs are activated once in the body, said the study's senior author, Dr. M. Michael Wolfe, a gastroenterologist and chair of the department of medicine at MetroHealth System. "In order to activate the medicine, you must eat. For that reason, you take it before ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Prevacid OTC

Acid-Reflux Drugs Tied to Lower Levels of Vitamin B-12

Posted 10 Dec 2013 by Drugs.com

TUESDAY, Dec. 10, 2013 – People who take certain acid-reflux medications might have an increased risk of vitamin B-12 deficiency, according to new research. Taking proton pump inhibitors (PPIs) to ease the symptoms of excess stomach acid for more than two years was linked to a 65 percent increase in the risk of vitamin B-12 deficiency. Commonly used PPI brands include Prilosec, Nexium and Prevacid. Researchers also found that using acid-suppressing drugs called histamine-2 receptor antagonists – also known as H2 blockers – for two years was associated with a 25 percent increase in the risk of B-12 deficiency. Common brands include Tagamet, Pepcid and Zantac. "This study raises the question of whether or not people who are on long-term acid suppression need to be tested for vitamin B-12 deficiency," said study author Dr. Douglas Corley, a research scientist and gastroenterologist at ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Dexilant, Prevacid, Pepcid, Lansoprazole, Aciphex, Famotidine, Vitamin B12 Deficiency, Heartburn Relief, Zegerid, Rabeprazole, Pepcid AC, Zantac 150

Generic Aciphex Approved to Treat Chronic Heartburn

Posted 8 Nov 2013 by Drugs.com

FRIDAY, Nov. 8 – The first generic versions of the anti-GERD drug Aciphex (rabeprazole sodium) have been approved by the U.S. Food and Drug Administration for people aged 12 and older, the agency said Friday. Gastroesophageal reflux disease (GERD), also known as chronic heartburn, is a very common disorder characterized by backward flow of stomach acid to the esophagus. This process could damage tissue in the esophagus, the tube that connects the throat and stomach. License to produce generic rabeprazole was granted to Dr. Reddy's Laboratories, Kremers Urban Pharmaceuticals, Lupin Pharmaceuticals, Mylan Pharmaceuticals, Teva Pharmaceuticals and Torrent Pharmaceuticals, the FDA said. The drug is among a class called proton-pump inhibitors, which are designed to reduce the amount of stomach acid produced. Generic drugs, the FDA stressed, are equivalent to the brand-name versions in ... Read more

Related support groups: GERD, Aciphex, Rabeprazole

FDA Approves Aciphex Sprinkle (rabeprazole sodium) For Use in Children Ages 1 to 11

Posted 16 Apr 2013 by Drugs.com

Woodcliff Lake, NJ, March 26, 2013 - Eisai Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved Aciphex Sprinkle Delayed-Release Capsules 5mg and 10mg for the treatment of Gastroesophageal Reflux Disease (GERD) in children 1 to 11 years of age for up to 12 weeks. “We are proud to offer a new treatment option for young children who suffer from GERD,” said Lonnel Coats, president and CEO of Eisai Inc. “Eisai is committed to keeping the medical needs of patients and their families at the forefront of all that we do, as part of our human health care (hhc) corporate mission.” The approval of Aciphex Sprinkle is based on the results of a clinical trial of pediatric patients 1 to 11 years of age. The clinical trial was a multicenter, double-blind, parallel-group study conducted in 127 pediatric patients with endoscopically-proven GERD that consisted of a 12-week ... Read more

Related support groups: GERD, Aciphex, Rabeprazole, Gastroesophageal Reflux Disease

Health Tip: Before You Take This Heartburn Medication...

Posted 5 Apr 2013 by Drugs.com

-- A proton pump inhibitor, a drug commonly taken for heartburn, may cause side effects. The American Academy of Family Physicians lists these factors to consider before using a proton pump inhibitor (PPI): If you're a postmenopausal woman, talk with your doctor because a PPI could increase your risk for bone fractures. If you've been treated for a C. difficile infection, check with your doctor because PPIs may increase the risk of the infection returning. If you have problems with your immune system or are elderly, check with your doctor because PPIs may increase the risk of pneumonia. Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Protonix IV

Heartburn Meds May Often Be Taken for Too Long, at Too-High Doses

Posted 22 Feb 2013 by Drugs.com

FRIDAY, Feb. 22 – U.S. veterans with chronic heartburn are often prescribed higher-than-recommended doses of medicines to control the condition and many are kept on the drugs far too long, according to a new study. Researchers looked at 1,600 veterans who were diagnosed with chronic heartburn – also known as gastroesophageal reflux disease (GERD) – and prescribed a type of drug called a "proton pump inhibitor," such as Prilosec (omeprazole). GERD arises when the ring of muscle between the esophagus and stomach fails to close properly, allowing stomach acids to splash up into the esophagus. The main symptom is chronic heartburn. These drugs – which also include Prevacid (lansoprazole) and Nexium (esomeprazole) – are among the most widely used drugs in the United States and provide relief for many patients with chronic heartburn. However, proper prescribing is required to avoid ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Protonix IV

Which Hospital Patients Need Drugs to Prevent Gastrointestinal Bleeding?

Posted 10 Jan 2013 by Drugs.com

THURSDAY, Jan. 10 – Researchers have developed a scoring system to help doctors determine which hospital patients can be prescribed stomach acid-suppressing drugs to prevent gastrointestinal bleeding and which patients should not be given such medications. Gastrointestinal bleeding in hospital patients is rare, but it is dangerous and potentially fatal, according to the study authors. Although the use of acid suppressants to prevent gastrointestinal bleeding in patients who are not critically ill is not widely recommended, the medications are commonly used for this purpose, said Shoshana Herzig and colleagues at the Beth Israel Deaconess Medical Center in Boston. The study was published online recently in the Journal of General Internal Medicine. The researchers analyzed data from more than 75,000 hospital patients admitted over three years and found that gastrointestinal bleeding ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Dexilant, Prevacid, Pepcid, Lansoprazole, Aciphex, Famotidine, Heartburn Relief, Zegerid, Rabeprazole, Pepcid AC, Zantac 150, Esomeprazole, Pepcid Complete

FDA Medwatch Alert: Proton Pump Inhibitors (PPIs) - Drug Safety Communication: Clostridium Difficile-Associated Diarrhea (CDAD) Can be Associated With Stomach Acid Drugs

Posted 8 Feb 2012 by Drugs.com

AcipHex (rabeprazole sodium) Dexilant (dexlansoprazole) Nexium (esomeprazole magnesium)  Omeprazole (omeprazole) Over-the-Counter (OTC) Prevacid (lansoprazole) and OTC Prevacid 24hr Prilosec (omeprazole)  and OTC Protonix (pantoprazole sodium) Vimovo (esomeprazole magnesium and naproxen) Zegerid (omeprazole and Sodium bicarbonate) and OTC   [Posted 02/08/2012] ISSUE: FDA notified the public that the use of stomach acid drugs known as proton pump inhibitors (PPIs) may be associated with an increased risk of Clostridium difficile–associated diarrhea (CDAD). A diagnosis of CDAD should be considered for patients taking PPIs who develop diarrhea that does not improve. The FDA is working with manufacturers to include information about the increased risk of CDAD with use of PPIs in the drug labels. FDA is also reviewing the risk of CDAD in users of histamine H2 receptor blockers. H2 rece ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Vimovo, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Kapidex, Dexlansoprazole, Zegerid OTC, Esomeprazole/naproxen, Omeprazole/Sodium Bicarbonate

Heartburn Drugs May Raise Fracture Risk in Older Women

Posted 31 Jan 2012 by Drugs.com

TUESDAY, Jan. 31 – Older women who take popular medications to control indigestion and heartburn may put themselves at higher risk for hip fractures, researchers report. Long-term use of these drugs, called proton pump inhibitors (PPIs), may increase that risk by 35 percent to 50 percent for current or former smokers, the researchers added. Prilosec, Nexium and Prevacid are some examples of these medications. "Although PPI use might be strongly indicated in some patients, at least for short-term use, we believe that clinicians should continue to carefully monitor the need for long-term use of these medications, specifically among postmenopausal women with a history of smoking," said lead researcher Dr. Hamed Khalili, a clinical and research fellow in gastroenterology at Massachusetts General Hospital in Boston. "Our data supports the recent decision by the U.S. Food and Drug ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Protonix IV, Omesec

Heartburn Meds Won't Help, May Harm Kids With Asthma

Posted 24 Jan 2012 by Drugs.com

TUESDAY, Jan. 24 – Children with asthma who don't have heartburn and other signs of gastroesophageal reflux don't get additional asthma control from acid-reducing medications, according to new research. And, taking these medications when there are no digestive issues increases a child's risk of developing a respiratory infection, reports the study. "There's a strong epidemiological link between acid reflux and asthma," explained study co-author Janet Holbrook, an associate professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health in Baltimore. As a result, current asthma guidelines call for evaluating people with asthma for acid reflux, Holbrook said. Because definitive tests for excess acid production can cause children discomfort, some doctors may choose to do a trial of acid-suppressing medications called proton pump inhibitors (PPIs). Some common brand names ... Read more

Related support groups: GERD, Asthma, Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate

No One Treatment for Acid Reflux Clearly Better Than Another: Study

Posted 29 Sep 2011 by Drugs.com

THURSDAY, Sept. 29 – Medications are effective for most patients with acid reflux disease, but some surgical options may be just as effective, according to a review of studies on current treatments for this common condition. Acid reflux disease, also known as gastroesophageal reflux disease or GERD, occurs when the contents of the stomach – including burning acid – chronically spill up into the esophagus, causing heartburn and other symptoms such as a persistent cough, laryngitis and asthma. Acid reflux disease may afflict as many as 4 percent of Americans, resulting not only in a sometimes significant financial drain but also more serious long-term consequences such as esophageal cancer, according to background information in the report released Sept. 23 by the U.S. Agency for Healthcare Research & Quality (AHRQ), part of the U.S. Department of Health & Human Services. Obesity, ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Dexilant, Prevacid, Pepcid, Lansoprazole, Aciphex, Famotidine, Heartburn Relief, Zegerid, Rabeprazole, Pepcid AC, Zantac 150, Esomeprazole

Popular Heartburn Meds May Boost Fracture Risk

Posted 9 May 2011 by Drugs.com

MONDAY, May 9 – Reinforcing U.S. health officials' concerns, new Korean research suggests that long-term use of popular heartburn drugs such as Prilosec, Prevacid and Nexium is linked to an increased risk of fractures. Scientists conducting a meta-analysis of 11 studies published between 1997 and 2011 found that proton pump inhibitors (PPIs), which reduce stomach acid production, were associated with a 29 percent increased risk of fracture. This included a 31 percent higher risk of hip fractures and a 54 percent heightened risk of vertebral fractures. Another class of heartburn drugs known as H2-receptor antagonists or H2 blockers – which include brand names such as Zantac and Pepcid – were not significantly linked to fracture risk, according to the study authors. H2 blockers, however, are less powerful than PPIs at suppressing acid production, blocking only about 70 percent rather ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Protonix IV, Omesec

FDA Drug Safety Communication: Low Magnesium Levels Can be Associated with Long-term Use of Proton Pump Inhibitor Drugs (PPIs)

Posted 3 Mar 2011 by Drugs.com

Silver Spring, Md., March 2, 2011--The U.S. Food and Drug Administration (FDA) is informing the public that prescription proton pump inhibitor (PPI) drugs may cause low serum magnesium levels (hypomagnesemia) if taken for prolonged periods of time (in most cases, longer than one year). In approximately one-quarter of the cases reviewed, magnesium supplementation alone did not improve low serum magnesium levels and the PPI had to be discontinued. PPIs work by reducing the amount of acid in the stomach and are used to treat conditions such as gastroesophageal reflux disease (GERD), stomach and small intestine ulcers, and inflammation of the esophagus. In 2009, approximately 21 million patients filled PPI prescriptions at outpatient retail pharmacies in the United States.2 Patients who take prescription PPIs usually stay on therapy for an average of about 180 days (6 months).3 Prescription ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Dexlansoprazole, Kapidex, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Protonix IV, Omesec

Heartburn Drugs May Raise Pneumonia Risk

Posted 21 Dec 2010 by Drugs.com

MONDAY, Dec. 20 – Popular heartburn drugs, including proton pump inhibitors and histamine-2 receptor antagonists, may raise the risk of pneumonia, new research finds. Researchers in Korea analyzed the results of 31 studies on heartburn drugs published between 1985 and 2009. "Our results suggest that the use of acid suppressive drugs is associated with an increased risk of pneumonia," said Dr. Sang Min Park of the department of family medicine at Seoul National University Hospital in Korea. "Patients should be cautious at overuse of acid-suppressive drugs, both high-dose and long duration," he added. Sales of these enormously popular drugs – the second best-selling category of medications worldwide – reached nearly $27 billion in the United States in 2005, according to background information in the study, published Dec. 20 in CMAJ (Canadian Medical Association Journal). Proton pump ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Zantac, Pantoprazole, Ranitidine, Dexilant, Prevacid, Pepcid, Lansoprazole, Aciphex, Famotidine, Heartburn Relief, Zegerid, Rabeprazole, Pepcid AC, Zantac 150, Vimovo

No Link Between Heartburn Drugs and Birth Defects: Study

Posted 24 Nov 2010 by Drugs.com

WEDNESDAY, Nov. 24 – Babies born to women who took a popular class of heartburn drugs while they were pregnant did not appear to have any heightened risk of birth defects, a large Danish study finds. This class of drugs, known as proton-pump inhibitors (PPIs), include blockbusters such as Prilosec (omeprazole), Prevacid (lansoprazole) and Nexium (esomeprazole). All were available by prescription-only during most of the study period (1996-2008), but Prilosec and Prevacid are now sold over-the-counter. While the authors and an editorialist, publishing in the Nov. 25 issue of the New England Journal of Medicine, called the results "reassuring," experts still recommend using drugs as little as possible during pregnancy. "In general, these are probably safe but it takes a lot of time and a lot of exposures before you see some of the abnormalities that might exist," explained Dr. Eva ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Protonix, Pantoprazole, Dexilant, Prevacid, Lansoprazole, Aciphex, Zegerid, Rabeprazole, Vimovo, Esomeprazole, Prilosec OTC, Prevacid SoluTab, Kapidex, Dexlansoprazole, Zegerid OTC, Omeprazole/Sodium Bicarbonate, Esomeprazole/naproxen

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GERD, Barrett's Esophagus, Zollinger-Ellison Syndrome, Erosive Esophagitis, Duodenal Ulcer Prophylaxis, Duodenal Ulcer, Helicobacter Pylori Infection, Stomach Ulcer, Gastric Ulcer

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