I started 2 months ago taking once a week alendronate sodium and I also have rheumatoid arthritis. So also on prednisone, leucovorin, and methotrexate. I am having issues with the alendronate such as gas and bowels frequently and very soft. Could this be due to this regiment for osteoporosis or my combination with ra meds? thanks in advance I am a 52 year old female.