Sarcoidosis - Is the Methotrexate better than Prednisone, which one give better results?

Hi Smartel127,I don't know which is better for your condition, but if you have problems with Prednisone, Methotrexate could be an alternative. It takes a while for Methotrexate to become effective, whereas the Prednisone have an immediate effect, there are side effects with both, but the Methotrexate is very effective at reducing inflammation, working in a similar way to steroids (such as Prednisone) and so is often prescribed as a steroid sparer, if you take it as prescribed once a week, and as I was advised to do, late in the day with your last meal, then take your folic acid tablets several days later, you should suffer less side effects.

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With your Fosamax (to protect your bones) take them (usually once weekly) on an empty stomach first thing in the morning with a large amount of water, and then don't eat anything or lie down for half an hour, which should minimise any side effects, but always report back to your doctor if you do find you are suffering any side effects at all. When you are on Methotrexate you are usually blood tested weekly initially and then every month so any problems can be picked up and dealt with immediately. Hope this will help you make a decision about your meds. Best wishes for your future health, bacterial