I'm in the process of titrating my lamictal dose up from 25mg to 100mg. I was at 50mg for 2 wks and and this week going up to 75mg. I have not felt well at all so far, just very depressed. Depressed is usually my predominant state, however it's really pretty bad and I keep waiting for a sign that this med is going to help. Has anyone here had this experience while starting lamictal? How long before improvement is noticed?
31 Jul 2012
When I started taking Lamictal, I had just gotten out of the psych hospital because I was suicidal. I started to feel like a new woman somewhere between 75 mg and 100 mg. A miracle medication for me. I finally had my life back under control again. I didn't think it could get much better, but it did. At my maintenance dose of 200 mg, along with my Klonopin, I was the best i had been in since I don't know when, and I've been dealing with my disease for 43 years. And on top of that, I didn't need a SSRI, SNRI, or anything else for my bipolar.
Just hang in there, your good life will be here soon.
I will pray for your return to a stable place for your wounded soul. I believe this will be a miracle for you also.
Peace and have a groovy life.
31 Jul 2012
Hi Kate5. I'm Anna. I've been taking Lamictal for five years. Before Lamictal, I took Lithium for 6 months. It was ineffective. I felt like you do, in that the depression continued. If I remember correctly, I felt better when I started taking Lamictal, slowly, over a 24 hr. period. I'm not saying I was mentally balanced at that time. I am what is called an "Extreme Bipolar 1." I was in mania for 6 months, homeless. I was a mad woman. I stopped taking Klonopin and that's what caused the manic episode. So, for me to say I was mentally balanced after starting Lamictal would be a complete lie. I felt a whole lot better after two weeks or so after starting Lamictal. I'm now at 400 mg. of Lamictal, 4 mg. of Klonopin, and within the last year and a half, 1800 mg of Gabapentin was added. I feel better than I have in 5 years. I have my down time. However, when I do have depression, it's situational.
When I have something seriously wrong in my life that would cause anyone depression, that's situational, such as divorce or death. Increasing the meds or adding meds would be useless. I have to get past the crying, the hurt, the guilt, the anger, and all the emotions that I feel. Sometimes I have depression for "no" reason, but it doesn't seem to last long. For me, this combination is a blessing. The Gabapentin really helped me a lot for depression and also pain. I couldn't believe it. I'm so much more balanced than I have been in 5 years. I think for all of us have to find the right combination of meds. Please, Kate, talk to your Dr.. I'm in no way a professional. What I'm telling you is my experience with Lamictal. Sometimes answers are more than yes or no. That's why I elaborated my explanation. I pray that the depression goes away. My heart and soul understand you. God bless you and take care, Kate. Anna
23 Aug 2012
Lamictal started making a difference for me after either 75 or 100mg. It was a slow process of titration, and I often felt hopeless about the med ever working when I was on low dosages for several months. I got a lot better, though! It just took time. Give the lamictal a chance and hang in there while you wait for it to start helping. It may take up to 200mg before you feel a big difference. My doctor told me that generally 200mg is the therapeutic dosage.
26 Jan 2013
I found relief when I hit 100 mg. I started noticing a difference. I don't recall ever having a negative side effect from the Lamictal. I have been on this med for 15 years and even though I may go through some rough patches, I am better than before the Lamictal... for sure! I am currently on 200 mg in the morning and around 6p. I prefer the afternoon dose over a bedtime dose. Lamictal seems to wake me up, but I know we are all different when it comes to meds
11 Jul 2013
Let me just start by prefacing that I am NOT a doctor. But in my case I started slowly with the small increase in the beginning. Felt pretty good after hitting 200mg. Kept going till I hit 400, (2, 200MG pills a day 6 hours apart) felt really good. Anxiety really low, which was a great experience since I've had anxiety my entire life. My metabolism's weird so maybe my 400mg is equivalent to your 200.
If you do go up in your dosage make sure to do it slowly. (probably 50mg increase a week should be fine) I've read that the most likely time you'll get that rash is if you increase your dose huge over a very small period of time.
15 Oct 2013
Hi, Ive been taking Lamictal for the past 8 months. This is combined with 100mg Sertraline and 300mg pregabalin. I have struggled to managed mixed depression and anxiety since i was 19. Im now 34.
I would say the introduction of Lamictal has been the best thing i have ever done. I cant recall feeling this well for the last 15 years, Its really been a miracle drug for me. I titrated up from 25mg per per day and after 4 weeks holding at 100mg. I have to say i didn't feel any effect until i hit 75mg then bam, one morning i woke up and the world looked and felt different to me. Ive been doing great ever since.
I urge anyone taking Lamictal to give it a chance, were all different and we all respond to different doses. Try ( and i know its not easy ) to stay positive, focus on the things that you would usually enjoy even if you dont feel like it do it anyway! look after yourself the best you can given your state at the time, the right meds will do the rest.
Peace and best wishes to all. Keep going, your journey will be worth it.
24 Apr 2014
I am new to this site and this is my story. I had panic attacks about two years ago and got SSRI and suffered as hell till they started kicking in. Then i was great. Toi great for a year. When i stopped taking it things got worse. My mood was shifting all the time from depression to anxiety etc. So i thought i need AD again. Took zolofit which literally made me crazy and now i am on mood stabilzer Lamictal. I am taking 75mg and my dc said my doze will be 100mg and nothing else.
I guess i feel better. I sleep and eat well. But i am depresses more i was before. Also i am thinkibg about dying and it is making me scares. Other than that i have no side effects. I do hope Lamictal will work but i am scared... and i hope i'll get some response from someone... making me feel better and tell me 'i was feeling the same' but Lamictal helped me just hang on.
waiting desperately for any reply and wish you the best...
27 Jun 2015
I know that this is an older post but wanted to add my experience for anybody new looking for recent answers. Also, it would be nice to see how lamictal has worked for everybody in the long-term.
I'm 43 and have struggled with bipolar 2 with rapid cycle mixed episodes and depression for most of my life. I never had the "happy" manic episodes - mine manifested as rage. Needless to say, I destroyed a lot of relationships until I finally admitted it was me and sought help.
I started on lamictal and titrated up from 25 mg to 200 over the course of 5 weeks. I started feeling better at around 75mg and am doing extremely well at 250. I have a whole new life now and wish that I had sought help years ago! I'm also on 1 mg of klonopin at night and am now sleeping 8 hours a night, with no nightmares. I was only sleeping about 3-4 hours per night before the meds and had horrible nightmares. Sleep is crucial to mental (and physical ) health.
This combination has given me a new lease on life. I didn't realize how bad I was - I just thought everybody felt that way.. I still sometimes have a bit of anxiety but it's extremely manageable.
Hang in there and give the lamictal a chance. I hope you have the same success that I have!
29 Jul 2015
So sad this morning, so glad I found this discussion.
I've recently been diagnosed bipolar & psych has started me on Lamactil. Frustrating as it's going so slow - 25mg every second day for two weeks, now 25 mg daily for two weeks until I see him again. We r working up to 200mg which will take soooo long. Right now I'm just so sad all the time, especially in the mornings after I drop my daughter at school. I feel without hope but hearing such encouraging remarks about this drug sure is reassuring.
I'm also on 10-15mg Saphris daily to help with intense irritability which has really worked curb that.
It's just this overwhelming sadness everyday that is hard to handle right now.
14 Oct 2015
Hello- I'm new here... How is everybody here doing on the lamictal since? I have severe depression (just diagnosed bipolar after I crashed after a really high couple of month).
On Lamictal 2 weeks at 25mg and now a couple of days on 50mg and no change yet... Taking one day at the time but it's so hard...
Thank you in advance for replying!!!
I hope you're all doing better, that's what I need to hear!! :)
23 Nov 2015
I am feeling hopeless about this drug. When I was in the doctor's office his parting words to me were "Your prognosis is good." I have been suffering from a severe, chronic depression since my early teens, and every drug I've been prescribed for it has been ineffective. I went to see a Psychiatrist this past summer, and he thought Lamotrigine would be the best drug for me. I have slowly worked up to 200mg (100mg 2X per day) and I feel nothing. I'm still weepy, I'm extremely irritable, I'm still not interested in doing anything at all, and I go to bed around 8:30pm with my kids. I have horrible sleeps (something the doc thought this medication would help with), and I always wake up tired.
Has anyone gone higher in dosage? I wasn't diagnosed with Bipolar since I don't get the highs, but the doc called me "Bipolar-ish" since I have the lows, and lowers. I've never been happy in my life. :( I want desperately to feel hopeful and to be happy.
- Lamictal Information for Consumers
- Lamictal Information for Healthcare Professionals (includes dosage details)
- Side Effects of Lamictal (detailed)
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