I was prescibed prednisone for serious sinus issues; 60 mgs. for 5 days and gradually tapering off over 14 days total. About 1/2 way through I began feeling deeply dipressed and had quick weight gain. Since I had quit smoking only 8 weeks previous to this, I had already gained some weight but felt I had my eating back under control. I had also been using Zyban to help me through the quitting smoking but had stopped just a day or 2 before starting this prednisone regimen. At the thime, I thought my depression was a result of the weight gain which I blamed on the non-smoking/metabolism shift(?). Never the less, I was a mess; crying all the time, not wanting to be around anyone, exhausted. I had such an argument with my daughter and husband, I ran out and bought cigarettes and smoked! Stupid, I know but I was definately out of control. As the days went by and the depression got worse I decided to check the side effects for prednisone. Could this REALLY be a result of the prednisone? I've been off it now for 10 days and I still don't feel much better yet. I don't seem to be still gaining weight but I am still depressed. Does anyone know how long it takes for this to be totally out of your system? Any info would be greatly appreciated
23 Jul 2012
Yes, yes, yes. Prednisone causes emotional changes and increased anxiety. Especially at your level. Call the doctor and tell him about your side effects. He should be able to give you something like Xanax to get you through this time. It helps one feel back in control of ones moods.
You figured out most the issues. Keep a low salt diet to reduce the water weight gained. Good news is when you end, the weight will drop off.
At sixty you will be pretty hyper. Stay away from anything disturbing including films, TV and switch to only happy things. Read, rest. You can do this. Getting healthy is the goal. Glad it will be temporary. Oh, and be sure you talk with family so they know this is not the normal you and that the meds do this. It does help things go smoother.
Your friend, endless prednisone, getting through seven years of this med and stayin' alive. Karen
24 Jul 2012
Upset .. Prednisone does cause depression, as well stays in your system for a long time, but since you were on it a short time it could maybe stay in your body for about 2 to 3 weeks. Drinking plenty of water will help you to flush it out of your system. The Zyban (Wellbutrin) should help you with your depression, however, it may cause you to be nervous, and hyper, Also prednisone can also cause the feelings of nervousness, so try taking the Zyban before 2:00 pm. You may want to ask the doctor to give you an antidepressant while you are having those feelings. If it were me I would try to stay away from Xanax as it is very addicting and hell to get off of. I hope this has helped... pamee
24 Jul 2012
Thank you ALL for the great info. I did go back on the Zyban yesterday, hoping that might help lift my spirits and help me back OFF the cigarettes! It was really difficult to quit smoking and having 8 weeks under my belt - I'm so disappointed that I allowed myself to fall back. For me, having an idea of how long I might suffer with these side effects (ie. how long the prednisone stays in my system), really helps me to go forward. If it was going to be 6 months, I would go directly to my GP and insist on something to counteract it. Since it should only be a couple more weeks, I will try the zyban and just wait it out. I will mention the problems when I see the ENT specialist next week who prescribed it. If she feels I need something more - I will consider it. Again, I can't thank you enough for helping me get through this!
24 Jul 2012
Absoluely!!! It will pass. Be sure to advice your dr that the steriods are affecting your mental health. Im not sure how long they stay in your system but I do know it is a decent amount of time. They keep on working after you stop taking them for quite a while is what I mean. good luck and remember, its just the meds..youre ok!
9 Nov 2012
I took Prednisone for 4 days for my hairtransplant surgery and after the 3 day my panic attack and anxiety kicked in. I had anxiety in the past and have been on effexor 75mg for my tinnitus,and this thing totally made me feel bad. After 4-6 weeks, I still feel very anxious and my doctor gave me xanax to cope, but it makes me feel tired..
IT's A TERRIBLE DRUG AND SHOULD BE BANNED.
Why don't doctors check w patients first before prescribing this crap?
9 Dec 2014
I was on prednisone two months ago, when I was on it I felt edgie so the Dr put me on Zoloft. Wow what a trip I put myself in the hospital thinking I was going nuts. I was in for 5 days when I got out I was fine, then the doctor changed my meds agian on me. Now I feel anxious and depressed, can meds really screw people up? I have been on prednisone before but never noticed the depression, agitation and anxious feelings. Or am I nuts?
- Prednisone Information for Consumers
- Prednisone Information for Healthcare Professionals (includes dosage details)
- Side Effects of Prednisone (detailed)
Search for questions
Still looking for answers? Try searching for what you seek or ask your own question.
2 answers • 18 Feb 2010
... long does Prednisone stay in the system. Will the thinning skin go away?
1 answer • 21 Jul 2010
How long until it will be totally out off my system. I am extremely weak and have severe back pain. Also depressed and very hopeless...
4 answers • 11 Jun 2014
... will it take to leave my system?
0 answers • 18 days ago