Pravachol and grapefruit? Why can't I eat grapefruit when taking pravastatin?

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"Grapefruit and Pravachol: An Overview
Unlike several other cholesterol-lowering statins, grapefruit products, such as grapefruit, grapefruit juice, and grapefruit supplements, do not appear to interact significantly with Pravachol® (pravastatin sodium). Therefore, people taking Pravachol do not need to avoid grapefruit products.

How Grapefruit Interacts With Other Statins
If you are taking a statin drug (other than Pravachol), be sure to talk with your healthcare provider about whether you can drink grapefruit juice or use other grapefruit products. This is because a number of statins are affected by grapefruit.

It is thought that grapefruit products interfere with an enzyme the body uses to break down certain statins, such as Zocor® (simvastatin), lovastatin (Mevacor®, Altoprev®) and, to a lesser extent, Lipitor® (atorvastatin). This means that these statins stay in the body longer than they normally would. For example, in one clinical study, Lipitor levels in the blood increased by 83 percent in those that drank grapefruit juice four times a day compared to the people who only drank water. For Zocor, blood levels of the drug can increase up to 12-fold in people who drink high doses of grapefruit juice."

http://www.drugs.com/pravachol.html

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