I have been on penicillamine to treat cystinuria from 1973 until 2011, but was changed over to Tiopronin last year. I am interested to know if the purpose of the mealtimes water drinking regime at for patients on Tiopronin is designed to leave behind insoluble amino acids (by diluting gastric juices) as distinct from the general benefits of a basic high fluid diet? See http://www.drugs.com/mmx/tiopronin.html