Skip to Content

Osteolytic Bone Lesions of Multiple Myeloma - What causes lesions?

Question is Closed
Report Favorite

Answers (1)

14 Oct 2009

The most visible aspect of myeloma disease is its effect on bones throughout the body.
Bone destruction by osteolytic lesions is caused by two separate events.

1. Rapid growth of myeloma cells inhibits normal bone-forming cells, damaging bone.

2.In addition, production of substances that activate the cells that resorb bone called osteoclasts is increased. Osteoclasts normally break down old or worn out bone and work with bone-forming cells to repair bone. Increased activity of osteoclasts, however, causes bone loss with concomitant loss of bone repair and growth from the suppression of bone formation.

Votes: +0

Search for questions

Still looking for answers? Try searching for what you seek or ask your own question.

Similar Questions

Is there a treatment equivalent to Zometa that is either Sub-Q or IM?

My veins will no longer support an IV (can't even get blood), and my port had to be removed. Suggestions?

1 answer 29 Nov 2012

Acute Myeloid Leukemia - Multiple myeloma & aml?

If you develop AML subsequent to treatment for Multiple Myeloma- treatment included stem cell transplant & revlimid, does physician report this ...

1 answer 6 Feb 2014

Hello to the DC Family! I've been gone for quite a while, haven't I?

I would like to share the events of the past 6 months and apologize to all of you for my absence on the site. My multiple myeloma relapsed in early ...

5 answers 23 Aug 2014

My fiancé has multiple myeloma and started revlimid today. How soon will will his pain start to?

... decrease after starting the revlimid? He has been so sick and in so much pain!

1 answer 3 Feb 2015

Burning pain caused by lesions your on rib cage?

I have multiple myeloma. Chemotherapy can cause this type of pain.

0 answers 8 Dec 2015