... I have just taken my 3rd dose of Relistor and have not had much support from my doctor on this drug. With each injection I have had the same effects; immediate nausea, abdominal cramping, gas, severe chills for about 2 hours, and no constipation relief at all. Does anyone else experience these issues? Does it take time to build up in your system for these side effects to go away and the constipation to subside?