I have been on Synthroid and the generic versions for nearly 30 years. I had Graves Disease in 1988 and was treated with radioactive iodine (twice within two weeks as I vomited the first time after two hours). I am now 48 years old and have become extremely tired. I have gained more than 80 pounds in the last few years. I don't feel that I think clearly, I feel mentally sluggish. Even though I sleep at least 8 hours each night, it never seems that I have any energy. I don't have any sex drive at all. My hair, skin and nails are very dry. I don't tolerate cold. The Endocrinologist that diagnosed me in 1989 is no longer practicing and my general practitioner says that my blood tests are normal and that I should continue to take the Synthroid at it's current prescription strength of .125mcg. I would love to find an effective treatment.